IDM Department News

Chancellor Gallagher shares his outrage, grief, and solidarity

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In a letter to the community, Chancellor Gallagher shares his outrage, grief, and anger. He challenges us all to demonstrate solidarity by standing with Pitt’s African American students, faculty, staff, and alumni in a shared commitment to realizing meaningful change. "How many times must we witness these blatant examples of injustice, hatred, brutality, and discrimination before we resolve to change things?"  We must plot a path forward.  ... 

Dutta awarded scholarship from U.S. State Department

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Congratulations to Justin A. Dutta (IDM '19, HUGEN '23) who was recently awarded a Critical Languages Scholarship from the U.S. Department of State to study Portuguese. With an acceptance rate of less than 10%, the Critical Language Scholarship is one of the country's most competitive scholarships and the most prestigious language program for U.S. citizens.   

Di, Deslouches, and Montelaro develop promising antibiotic molecule for drug-resistant infections

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CISTIC FIBROSIS NEWS TODAY - With the rising prevalence of superbugs, researchers are turning their attention to antibiotic molecules. Study co-authors Y. Peter Di (EOH), Berthony Deslouches (EOH), and Ronald Montelaro (IDM) have engineered a cationic antimicrobial peptide named WLBU2, licensed by Pitt spin-off Peptilogics, that's now in a clinical trial for preventing infections associated with knee and hip replacements.  

MAAETC receives CARES Act funding to help minimize impact of pandemic on those with HIV

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MidAtlantic AIDS Education and Training Center Receives $400,000 in CARES Act Funding to support efforts to ‘prevent or minimize the impact of this pandemic on people with HIV’  

The History and Future of COVID-19

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COVID-19 is one of three novel coronavirus outbreaks in the past 20 years that originated in animals. How is the current outbreak similar and different from the previous ones? What course will COVID-19 take in Pennsylvania?  IDM's  Amy Hartman  puts the current outbreak in perspective with what we know (and don’t know) about SARS-CoV-2. EPI's  Donald Burke  discusses the epidemiological and environmental factors that will shape the likely ph... 

Herpes virus infects billions of people worldwide. Rinaldo explains why there isn’t a vaccine yet.

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NBC NEWS – IDM's Charles Rinaldo said that many have tried to come up with vaccines that use two or three proteins out of the approximately 75 that make up the virus. Those would be safe, but have not protected well. Another approach has been to use a weakened form of the whole virus. In that attenuated, its replication capacity is weakened but it’s not as safe. These failures “are why this is such a monster.”  

Garcia-Bates assists Medical Reserve Corps with COVID-19 initiatives

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IDM’s Tatiana Garcia-Bates signed up to volunteer through the Allegheny County Health Department for the Medical Reserve Corps (MRC), where she instructed a local nursing center's staff on proper N-95 respirator fit.  

Salunke accepted into Internal Medicine Residency at the University of Connecticut

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Graduating master's student in IDM's community practice track Rajeev Salunke (IDM '20) has been accepted into the internal medicine residency program at the University of Connecticut. Hear directly from Rajeev about his background, his experiences at Pitt Public Health, and his aspirations for the future.   

Chinese biotech reports COVID-19 vaccine protects monkeys from new coronavirus, but Reed is cautious

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SCIENCE - IDM's Douglas Reed, who is developing and testing COVID-19 vaccines in monkey studies, says the number of animals was too small to yield statistically significant results. His team also has a manuscript in preparation that raises concerns about the way the Sinovac team grew the stock of novel coronavirus used to challenge the animals: It may have caused changes that make it less reflective of the ones that infect humans.  

What it’s like for IDM student Emerson Boggs and team to moderate Reddit’s wildly popular coronavirus forum

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VICE MEDIA – Emerson Boggs (IDM PhD candidate) says, “I’m a virologist, so I probably spend more time than average looking at outbreaks. I started off as a fervent commenter, and then I wanted the ability to intervene because the science stuff got bad pretty quickly.” The subreddit is also rapidly outpacing traditional outbreak reporting. The ability to communicate back and forth easily has helped a lot of people.  

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Recent IDM Publications

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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

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IDM Videos

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The History and Future of COVID-19 

The History and Future of COVID-19

COVID-19 is one of three novel coronavirus outbreaks in the past 20 years that originated in animals. How is the current outbreak similar and different from the previous ones? What course will COVID-19 take in Pennsylvania?  IDM's  Amy Hartman  puts the current outbreak in perspective with what w... (05/12/2020)
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Rinaldo remembers unsung heroes: Pittsburgh men, decades-long study impact HIV/AIDS research 

Rinaldo remembers unsung heroes: Pittsburgh men, decades-long study impact HIV/AIDS research

U.S. NEWS & WORLD REPORT - For more than three decades, Pitt Men’s Study leaders have gathered with Pittsburgh men and women to remember those who have died and give thanks for the 1,743 men who have participated in the nation’s longest-running HIV/AIDS research project. IDM's Charles Rinaldo has l... (12/21/2019)
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Smith talks in-depth immunotherapy for lung cancer 

Smith talks in-depth immunotherapy for lung cancer

HOPE WITH ANSWERS - Discover in-depth information about immunotherapy for lung cancer through this conversation between Kellie Smith (IDM '13) of Johns Hopkins and patient advocate Lysa Buonanno, part of a video series providing the next level of information for patients to understand treatment opt... (08/12/2019)
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Hartman among researchers trying to prevent virus more dangerous than Zika (video) 

Hartman among researchers trying to prevent virus more dangerous than Zika (video)

WPXI - Pitt researchers are looking to lessons learned about Zika when preparing for the possibility of Rift Valley Fever virus, noting that it's important to develop therapies and vaccines now. "We saw the ffects of Zika when it got into a larger population and so our work highlights the need to r... (02/11/2019)
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IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO) 

IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO)

UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1998 World AIDS Day, Pitt IDM AIDS researcher Charles Rinaldo and the late Bridget Murtagh of th... (07/17/2018)
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