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IDM Master's Defense

Jocelin Teachout - Strategies to Reduce the High Cost of Hepatitis C Treatment: A Literature Review

Wednesday 12/13 1:00PM - 2:00PM
Public Health A425

Strategies to Reduce the High Cost of Hepatitis C Treatment: A Literature Review

Abstract: Hepatitis C infection is a chronic, debilitating disease with complications such as liver cancer and liver cirrhosis. In the United States, hepatitis C infection can be cured only with direct acting antiviral treatment. However, the cost of hepatitis C treatment is expensive, hindering many Americans from receiving treatment. Insurance companies and pharmaceutical companies control access to hepatitis C treatment as out-of-pocket costs are unaffordable for most individuals. A literature review was conducted to investigate strategies to reduce the high cost of hepatitis C treatment using PubMed database. The research question of “What are current or future strategies that could reduce the high cost of hepatitis C treatment in the US market to increase access?” focused this literature review’s purpose. Relevant studies were those published from 2013 to present that included strategies to decrease the cost of hepatitis C treatment. Articles were excluded if they included a genotype other than genotype 1, represented studies conducted in a country other than the United States, or a specific clustering of individuals in the title such as injection drug users, at-risk populations, and prison inmates. Thirty-one studies met the criteria for inclusion in this literature review. The results of this literature review indicated that 15 articles believe increased market competition (48.3%) decreases the cost of hepatitis C treatment. Modifications to the pharmaceutical industry was emphasized in 12 articles (38.7%) such as promoting competition, research of equivalent drugs, and partnerships with other pharmaceutical companies as a means of decreasing hepatitis C treatment costs. Eleven articles claimed that stakeholder involvement (35.5%) reduces hepatitis C treatment costs. Eight studies claimed that business/finance industry modifications (25.8%) lower hepatitis C treatment costs. These studies assist in developing strategies to reduce the high financial burden on people living with hepatitis C and furthering public health significance in reducing hepatitis C transmission.

Last Updated On Tuesday, December 05, 2017 by Michael, Abby Marie
Created On Tuesday, December 05, 2017

Recent Master's Topics

Wed 12/13/2017
Alison Feathers - Hepatitis C in Allegheny County: 2015-2016 IDM Master's Defense
Alison Feathers - Hepatitis C in Allegheny County: 2015-2016
Wed 12/13/2017 2:00PM - 4:00PM
Public Health A216

Alison Feathers' MPH-MIC Thesis, Hepatitis C in Allegheny County: 2015-2016, describes the reported past/present hepatitis C cases in Allegheny County, Pennsylvania, from 2015 to 2016.

Wed 12/13/2017
Jocelin Teachout - Strategies to Reduce the High Cost of Hepatitis C Treatment: A Literature Review IDM Master's Defense
Jocelin Teachout - Strategies to Reduce the High Cost of Hepatitis C Treatment: A Literature Review
Wed 12/13/2017 1:00PM - 2:00PM
Public Health A425

Jocelin Teachout's Essay, Strategies to Reduce the High Cost of Hepatitis C Treatment: A Literature Review, assists in developing strategies to reduce the high financial burden on people living with hepatitis C and furthering public health significance in reducing hepatitis C transmission.

Wed 12/6/2017
Erica Berry - Factors influencing the utilization of intermittent preventative treatment in pregnant IDM Master's Defense
Erica Berry - Factors influencing the utilization of intermittent preventative treatment in pregnant
Wed 12/6/2017 1:30PM - 2:00PM
Public Health A425

Erica Berry's MPH-MIC Essay, Factors influencing the utilization of intermittent preventative treatment in pregnant women for malaria in the African region: A literature review, aims to inform interventions to increase rates of utilization and adherence by reducing barriers to ANC, implementing consistent guidelines for administration, and incorporating IPTp into malaria education.

Wed 12/6/2017
JT Stoner - Investigating the Impact of Human Rights Violations on Access to HIV Prevention... IDM Master's Defense
JT Stoner - Investigating the Impact of Human Rights Violations on Access to HIV Prevention...
Wed 12/6/2017 12:00PM - 12:30PM
Public Health A425

JT Stoner's MPH-MIC Essay, Investigating the Impact of Human Rights Violations on Access to HIV Prevention & Treatment Services For Men Who Have Sex With Men in Africa, aims to contextualize the extent to which criminalization of homosexuality and human rights violations impact access to HIV-related healthcare and risk for HIV infection among MSM in African countries and to compare these findings within and between the various regions of Africa. 

Tue 12/5/2017
Ruhee Jain - Understanding the Role of Astrocytes in HIV-1 Neuropathogenesis: Novel strategies to... IDM Master's Defense
Ruhee Jain - Understanding the Role of Astrocytes in HIV-1 Neuropathogenesis: Novel strategies to...
Tue 12/5/2017 1:00PM - 2:30PM
Public Health 2140

Ruhee Jain's Thesis, Understanding the Role of Astrocytes in HIV-1 Neuropathogenesis: Novel strategies to target astrocyte function and HIV-1 Associated Neurocognitive Disorder, aims to generate and characterize the astrocyte cell lines expressing candidate miRNAs along with appropriate control and to determine whether the overexpression of these candidate miRNA block virus replication. 

Mon 8/7/2017
Mariah Cole - MS Defense IDM Master's Defense
Mariah Cole - MS Defense
Mon 8/7/2017 11:00AM - 1:00PM
Public Health Lecture Hall (A115)

Mariah's thesis, Pre- and Post Seroconversion Gut Microbiome Analysis in HIV-infected individuals, investigates the gut microbiome of 16 untreated HIV-infected men who have sex with men (MSM) at time-points that are ~6 months pre-seroconversion and ~6 months post-seroconversion to assess bacterial changes that may make individuals more susceptible to the development of AIDS, using Multicenter AIDS Cohort Study (MACS) fecal samples from 1984-1985.

Fri 6/23/2017
Tiffany Thompson - MPH PEL Essay IDM Master's Defense
Tiffany Thompson - MPH PEL Essay
Fri 6/23/2017 8:30AM - 9:30AM
Biomedical Sciences Tower 3 (BST3)

Tiffany Thompson will be presenting her essay on the 9th floor of the Center for Vaccine Research during one of her collaborative lab meetings. Her essay, A Literature Review of the Histology of Rift Valley Fever Virus Neurological Disease Comparing Rodent and NHP Models to Human Disease, will focus on the neurological disease seen in the developed animal models and the histology being used in the research of the Rift Valley Fever Virus.
Mon 6/19/2017
Marilee Clunk - MS Defense IDM Master's Defense
Marilee Clunk - MS Defense
Mon 6/19/2017 11:00AM - 1:00PM
Public Health A425

Marilee's defense, Siglec-10, CD1b, and Palladin are differentially expressed between HIV+ Progressors and Nonprogressors, aims to identify the underlying genetic factors that drive HIV-1 disease progression that could reveal potential therapeutic targets with the long term aim of improving HIV health outcomes. 
Thu 6/15/2017
Chris Healy - MS Defense IDM Master's Defense
Chris Healy - MS Defense
Thu 6/15/2017 2:00PM - 4:00PM
Public Health Lecture Hall (A115)

Chris Healy's Thesis, Evaluation of a Novel Computationally Designed Prophylactic against Pandemic Influenza Virus in the Ferret Model, provides compelling data for further evaluation of broadly protective novel therapeutics against influenza viruses.

Tue 4/25/2017
Sarah Sandrian - PCMI Essay IDM Master's Defense
Sarah Sandrian - PCMI Essay
Tue 4/25/2017 1:00PM - 2:00PM
Public Health 2140

Sarah Sandrian's Essay, Program Evaluation of a Structural Intervention Aimed at Improving Maternal Health Outcomes in Rural Zambia, aims to address the needs of pregnant women in resource poor settings as well as countries with similar health systems and challenges to improve maternal health and to engage communities in solving local problems through partnerships and collaboration. 
Fri 4/21/2017
Phil Han "Chemical-Biology Approach to Delineate the Mechanism on Action of HIV-1 Latency ..." IDM Master's Defense
Phil Han "Chemical-Biology Approach to Delineate the Mechanism on Action of HIV-1 Latency ..."
Fri 4/21/2017 9:30AM - 10:30AM
Public Health Auditorium (G23)

Phil Han's thesis defense, "Chemical-Biology Approach to Delineate the Mechanism on Action of HIV-1 Latency Reversing Agents"  will show you how he identified several kinase inhibitors that activated HIV-1 latent genes in a significant level individually, including CUDC-101, XMD8-92, PD173074, Quizartinib, and CUDC-907.

Thu 4/20/2017
Gregory Shedlock - MIC Essay IDM Master's Defense
Gregory Shedlock - MIC Essay
Thu 4/20/2017 12:00PM - 1:00PM
Public Health A425

Gregory Shedlock's essay "A Literature Review and Analysis of Organizational Frameworks and Systems-Level Outcomes of HIV Primary Care Integration" aims to review the current evidence-base for 1) frameworks and models of integration and how these may best be applied and 2) systems-level outcomes as a direct result of HPCI.

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Questions and Submissions

The schedule of defenses in the Department of Infectious Diseases and Microbiology is maintained by:

Abby Michael
abm82@pitt.edu 
412-624-3331

Share the details for your defense to ensure it is displayed here as well as on the department calendar, Pitt Public Health's calendar, Weekly Update, and LCD screens.

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