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IDM Faculty News

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease.  

New roles for Cauley and Ayyavoo

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JANE CAULEY, who has served as the associate dean for research, will be stepping down from that position to take on additional responsibilities as the executive vice chair of EPI. Cauley is also a distinguished professor of epidemiology. VELPANDI AYYAVOO, currently associate dean for faculty affairs and IDM professor, will become the associate dean for research and faculty affairs. Congratulations!   

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.   

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM interaction and downstream signaling cascades associated with synaptodendritic functions.   

In Harm’s Way: Women, HIV, Hep C, and Substance Use, hosted by MAAETC

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The MidAtlantic AIDS Education and Training Center hosted a conference that brought together regional experts to explore ways to increase awareness of the opioid and Hepatitis C epidemics affecting women and infants in Southwestern Pennsylvania. One outcome of note: they identified solutions to improve the current care model of clinical and behavioral health care for women of childbearing age who are opioid users.  

Mailliard on how cells talk and help one another via tiny tube networks

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SCIENTIFIC AMERICAN - Working with dendrites, what he calls "the quarterbacks of the immune system," IDM's ROBBIE MAILLIARD and colleagues are applying the budding field of TNT research to HIV. Now, they are investigating whether drugs that are commonly used to lower cholesterol levels could be repurposed to control viral infections.   

Marques on new device that could lead to earlier detection of outbreaks

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NEW YORK TIMES - Researchers created a device that can test a drop of blood to tell, in about half an hour, who's immune to certain infections and who's not. The goal is to find groups of people at risk of outbreaks, especially in impoverished and remote areas, in time to save lives. "We need to develop cheaper and more efficient ways to detect outbreaks earlier," said IDM's ERNESTO MARQUES. “This may be one step in that direction.”  

Rappocciolo presents research on cell cholesterol dysregulation in HIV non-progressors at 2018 Conference on Retroviruses and Opportunistic Infections

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IDM's GIOVANNA RAPPOCCIOLO presented at the Conference on Retroviruses and Opportunistic Infections ion biomarkers and genetics of cell cholesterol dysregulation in HIV non-progressors. Co-authors include IDM faculty J MARTINSON and C RINALDO and recent doctoral graduate DIANA DELUCIA.   

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches to prevent and treat infection with highly pathogenic avian influenza viruses.   

Amid opioid crisis, Frank addresses Titusville community

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TITUSVILLE HERALD - Community members and students from Pitt's Titusville campus gathered to hear IDM's LINDA FRANK discuss drug misuse versus drug abuse, the opioid epidemic's relation to to the spread of HIV/AIDS and Hepatitis C, available prevention and treatment strategies, and the implications for health professionals, families, community members, and local organizations.   

As Zika babies become toddlers, some can’t see, walk, or talk

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NEW YORK TIMES - Infectious disease researcher ERNESTO MARQUES says about 3 percent of 1,000 pregnant Brazilian women in a recent sample were infected with Zika. “The problem’s not going away. We are still having cases. And the future of Zika babies already born is complicated by poverty and strained resources. “Most of these babies are from low socioeconomic status and rely on the public health system to provide care. It’s very difficult to mana... 

Mailliard presents research on improving HIV “kick and kill” strategies to IAS Conference on HIV Science in Paris (Video)

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YOUTUBE - IDM's Mailliard presents his research on “kick and kill” strategies at the 9th IAS Conference on HIV Science, the world's largest open scientific conference on HIV and AIDS-related issues. The work demonstrates that naïve T cells have the ability to effectively target the HIV-1 reservoir, highlighting the importance of directing HIV-1 curative strategies towards the induction of de novo rather than memory HIV-1-specific CTL responses.  

Stall’s research helps to “Kick ASS”

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SAN FRANCISCO BAY TIMES - The reality of AIDS Survivor Syndrome (ASS) is now being confirmed by empirical research. On November 3, 2017, BCHS Associate Chair for Science RON STALL presented his findings on the subject in San Francisco at a provider and community town hall entitled “Research on the AIDS Survivor Syndrome: New Data from The Multi-Center AIDS Cohort Study and Voices of Survivors Themselves.” 

Marques: While Zika hasn’t been in the news much, that doesn’t mean it’s gone

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WASHINGTON POST - Local transmission seems to have come to a standstill, with one suspected case in Texas and one case confirmed in Florida. Herd immunity may be preventing more big outbreaks. But if Zika behaves like other arboviruses, it will probably stick around. They tend to be cyclical, says Pitt Public Health researcher ERNESTO MARQUES. “You have big booms, then they drop. Then a few years later, they come back again.” 

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Recent IDM Publications

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells 

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells

NATURE MEDICINE - Gupta, Sanyal, Ratner, Ding, Zerbato, Giacobbi, Venkatachari, Patterson, Chargin, Chen, Mailliard, Rinaldo, and Sluis-Cremer found that the size of the inducible latent HIV-1 reservoir in aviremic subjects on ART is approximately 70-fold larger than previous estimates.  (02/08/2018)

Peripheral blood biomarkers of disease outcome in a monkey model of rift valley fever encephalitis.  

Peripheral blood biomarkers of disease outcome in a monkey model of rift valley fever encephalitis.

JOURNAL OF VIROLOGY - Wonderlich, Caroline, McMillen, Walters, Reed, Barratt-Boyes, and Hartman conclude that African green monkeys are a novel and suitable model for studying the neuropathogenesis of Rift Valley Fever (RVF) and for testing vaccines and therapeutics against this important emerging ... (02/05/2018)
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