Marnie Bertolet

Contributions to Public Health

• Maternal and Child Health (MCH): My work in MCH has focused on the role of maternal factors that are associated with preterm birth. Much of this work has intersected with the cardiovascular disease contribution and also looked at future maternal health based upon pregnancy factors/complications.
  • Catov JM, Sun B, Lewis CE, Bertolet M, Gunderson EP. 
    Prepregnancy weight change associated with high gestational weight gain. Obesity. 2022 Feb;30(2):524-534. PubMed PMID: 35080338.
    Sun B, Gunderson EP, Bertolet M, Lopa SH, Bryan SG, Lewis CE, Catov JM. Inflammatory, metabolic, and endothelial biomarkers before and after pregnancy complications. 
    Am J Epidemiol. 2024 Oct 7;193(10):1407-1416. PubMed PMID: 38634618
• Life-course and aging: My work in this area has encompassed looking at how pregnancy factors impact long term outcomes for the mothers, impacts of menopause on women's health and investigating dementia and inflammation factors as people age.
  • Ehrenkranz R, Zhu X, Glynn NW, Bertolet M, Berman SB, Hengenius JB, Rosano C. Longitudinal Associations Between Higher Self-Reported Energy, Gait Speed, and Cognition in Older Adults With Fatigue. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2407-2414. PubMed PMID: 37774505;
  • Royse SK, Snitz BE, Hill AV, Reese AC, Roush RE, Kamboh MI, Bertolet M, Saeed A, Lopresti BJ, Villemagne VL, Lopez OL, Reis SE, Becker JT, Cohen AD. Apolipoprotein E and Alzheimer's disease pathology in African American older adults. Neurobiol Aging. 2024 Jul;139:11-19. PubMed PMID: 38582070.
• Health Equity: My work in this area has focused on subgroup analyses and studies specifically among Black and other populations of color. I have received a certificate in Diversity and Inclusion as well as the Diversity in the Curriculum award for my work at integrating diversity into my Design and Conduct of Clinical Trials course.
  • Royse SK, Snitz BE, Hengenius JB, Huppert TJ, Roush RE, Ehrenkranz RE, Wilson JD, Bertolet M, Reese AC, Cisneros G, Potopenko K, Becker JT, Cohen AD, Shaaban CE. Unhealthy white matter connectivity, cognition, and racialization in older adults. Alzheimers Dement. 2024 Mar;20(3):1483-1496. 2023 Oct 12. PubMed PMID: 37828730
• Clinical Trials (Cardiovascular Disease, Transfusion Medicine). My work on clinical trials includes individual R01 studies and large multicenter international NIH Funded U01 trials. I have been involved with numerous clinical trials as the only statistician, including the Wheel Chair 2 Trial and Statins for Pulmonary and Cardiac Complications of Chronic HIV (SPARC). As a coordinating center representative and/or lead statistician on large multicenter international trials (BARI 2D, MINT and  SCD-CARRE), I created DSMB packets including statistical interim monitoring.
  • Carrier FM, Cooper HA, Portela GT, Bertolet M, Lemesle G, Prochaska M, Kim S, Alexander JH, Crozier I, Ducrocq G, Quadros AS, Bagai A, Dracoulakis M, Madan M, Brooks MM, Carson JL, Hébert PC. Anemia Acuity Effect on Transfusion Strategies in Acute Myocardial Infarction: A Secondary Analysis of the MINT Trial. JAMA Netw Open. 2024 Nov 4;7(11):e2442361. PubMed PMID: 39485351.
  • DeFilippis AP, Abbott JD, Herbert BM, Bertolet MH, Chaitman BR, White HD, Goldsweig AM, Polonsky TS, Gupta R, Alsweiler C, Silvain J, de Barros E Silva PGM, Hillis GS, Daneault B, Tessalee M, Menegus MA, Rao SV, Lopes RD, Hébert PC, Alexander JH, Brooks MM, Carson JL, Goodman SG. Restrictive Versus Liberal Transfusion in Patients With Type 1 or Type 2 Myocardial Infarction: A Prespecified Analysis of the MINT Trial. 
    Circulation. 2024 Dec 3;150(23):1826-1836. PubMed PMID: 39206549; PubMed Central PMCID: PMC11611643.
• Epidemiological Methods: With a PhD in statistics, I look for ways to use novel or underused statistical techniques, as well as to update or enhance existing methods that do not exactly fit the question at hand.
  • Portela GT, Ducrocq G, Bertolet M, Alexander JH, Goodman SG, Glynn S, Strom JB, Swanson SA, Lemesle G, Rao SV, Tessalee M, Polonsky TS, Goldfarb M, Traverse JH, Uhl L, Herbert BM, Silvain J, Carson JL, Brooks MM. Individualized transfusion decisions to minimize adverse cardiovascular outcomes in patients with acute myocardial infarction and anemia. Am Heart J. 2025 Apr;282:146-155. PubMed PMID: 39826701.
  • Portela GT, Carson JL, Swanson SA, Alexander JH, Hébert PC, Goodman SG, Steg PG, Bertolet M, Strom JB, Fergusson DA, Simon T, White HD, Cooper HA, Abbott JD, Rao SV, Chaitman BR, Fordyce CB, Lopes RD, Daneault B, Brooks MM. 
    Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data. Ann Intern Med. 2024 Nov;177(11):1489-1498. PubMed PMID: 39348705.