Maria Mori Brooks, PhD

Professor, Epidemiology

Vice Chair for Education, Epidemiology

Professor, Biostatistics

Co-Director, Epidemiology Data Center

Contact

5119 Public Health, 130 DeSoto Street, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA 15261
R-znvy: zoebbxf@cvgg.rqh
Primary Phone: 967-179-6163
Secondary Phone: 967-179-0964
Fax: 967-179-2842

Assistant(s): 
Patricia Zogran, mbtena@cvgg.rqh, 967-179-0964

Personal Statement

My research has focused on the design, conduct, and analysis of multicenter clinical trials and cohort studies.  Most of my work has involved the evaluation of treatments and risk factors in patients with coronary disease and diabetes and the epidemiology of cardiovascular diseases and women’s health. I am the Principal Investigator of the Coordinating Center of the Study of Women's Health Across the Nation (SWAN), a multi-racial/ethnic longitudinal cohort study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. In addition, I am the Principal Investigator of the Data Coordinating Center for the Myocardial Ischemia and Transfusion (MINT) trial, a multicenter randomized clinical trial evaluating transfusion strategies for patients with acute myocardial infarction and anemia. Over the years, I have collaborated on projected involving pulmonology, infectious diseases, genetics, and behavioral interventions. I serve as the Vice-Chair for Education for the Department of Epidemiology and teach advanced epidemiological methods.

Education

1985 - Williams College, Williamstown, MA; BA, Mathematics, cum laude 

1986 - Harvard University, Cambridge, MA; MA, Statistics 

1991 - University of North Carolina, Chapel Hill, NC; PhD, Statistics

 

Teaching

 

 

  • 2012-Present: Epidemiology 2187, Epidemiological Methods 2
  • 2007-2012: Epidemiology 2181, Epidemiological Methods 1

 

 

 

 

 

 

 

ACTIVE RESEARCH STUDIES

  • Study of Women’s Health Across the Nation (SWAN) Coordinating Center. NIH/NIA, Maria Mori Brooks, PI 
  • Myocardial Ischemia and Transfusion (MINT) Data Coordinating Center. NIH/NHLBI, Maria Mori Brooks, PI 
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative, NIH/NHLBI, Stephen R. Wisniewski, PI 
  • Impact of Representative Payee Services on ART Adherence, NIH/NIMH, Mary Hawk, PI
  • Neuro-vascular Determinants of Cognition in Adults with Sickle Cell Disease, NIH/NHLBI, Enrico Novelli, PI 
  • Effects of Hormone Therapy on Heart Fat and Atherosclerosis Progression in Early Postmenopausal Women from the KEEPS Trial. NIH/N
  • HLBI, Samar R. El Khoudary, PI
  •  

 

Selected Publications

Mancini GBJ, Boden WE, Brooks MM, Vlachos H, Chaitman BR, Frye R, Bittner V, Hartigan PM, Dagenais GR. Impact of treatment strategies on outcomes in patients with stable coronary artery disease and type 2 diabetes mellitus according to presenting angina severity: A pooled analysis of three federally-funded randomized trials. Atherosclerosis. 2018 May 31 [Epub ahead of print] PMID:29861270. 

 

Chaitman BR, Mori Brooks M, Fox K, Lüscher TF.  ORBITA revisited: what it really means and what it does not? Eur Heart J. 2018 Mar 14;39(11):963-965. PMID: 29324991. 

 

Hanley C, Matthews KA, Brooks MM, Janssen I, Budoff MJ, Sekikawa A, Mulukutla S, El Khoudary SR. Cardiovascular fat in women at midlife: effects of race, overall adiposity, and central adiposity. The SWAN Cardiovascular Fat Study.  Menopause. 2018 Jan;25(1):38-45.  PMID: 28763398. PMCID: PMC5735027.
  

Green DJ, Brooks MM, Burckart GJ, Chinnock RE, Canter C, Addonizio LJ, Bernstein D, Kirklin JK, Naftel DC, Girnita DM, Zeevi A, Webber SA. The Influence of Race and Common Genetic Variations on Outcomes After Pediatric Heart Transplantation. Am J Transplant. 2017 Jun;17(6):1525-1539. PMID: 27931092. 

 

Matthews KA, El Khoudary SR, Brooks MM, Derby CA, Harlow SD, Barinas-Mitchell EJ, Thurston RC. Lipid Changes Around the Final Menstrual Period Predict Carotid Subclinical Disease in Postmenopausal Women. Stroke. 2017 Jan;48(1):70-76. PMID: 27909203. 

 

Ikeno F, Brooks MM, Nakagawa K, Kim MK, Kaneda H, Mitsutake Y, Vlachos HA, Schwartz L, Frye RL, Kelsey SF, Waseda K, Hlatky MA; BARI-2D Study Group. SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial. J Am Coll Cardiol. 2017 Jan 31;69(4):395-403. PMID: 28126156. 

 

Tepper PG, Brooks MM, Randolph JF Jr, Crawford SL, El Khoudary SR, Gold EB, Lasley BL, Jones B, Joffe H, Hess R, Avis NE, Harlow S, McConnell DS, Bromberger JT, Zheng H, Ruppert K, Thurston RC. Characterizing the trajectories of vasomotor symptoms across the menopausal transition. Menopause. 2016 Oct;23(10):1067-74. PMID:27404029. 

 

Mancini GB, Farkouh ME, Brooks MM, Chaitman BR, Boden WE, Vlachos H, Hartigan PM, Siami FS, Sidhu MS, Bittner V, Frye R, Fuster V. Medical Treatment and Revascularization Options in Patients With Type 2 Diabetes and Coronary Disease. Journal of the American College of Cardiology. 2016 Sep 6;68(10):985-95. PMID: 27585501. 

 

Bertolet M, Brooks MM, Bittner V. Tree-based identification of subgroups for time-varying covariate survival data. Statistical Methods Medical Research. 2016 Feb;25(1):488-501. PMID: 23070595. PMC Journal – In Process. 

 

Nguyen-Ha P, Howrie D, Crowley K, Vetterly CG, McGhee W, Berry D, Ferguson E, Polischuk E, Brooks MM, Goff J, Stillwell T, Darville T, Thompson AE, Levin JE, Michaels MG, Green M. A Quality Assessment of a Collaborative Model of a Pediatric Antimicrobial Stewardship Program. Pediatrics. 2016;137(5):e20150316. PMC Journal – In Process. 

 

Everett BM, Brooks MM, Vlachos HE, Chaitman BR, Frye RL, Bhatt DL; BARI 2D Study Group. Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes. New England Journal of Medicine. 2015 Aug 13;373(7):610-20. doi: 10.1056/NEJMoa1415921. PMID: 26267622. PMCID: PMC4627639. 

 

Chen YF, Yabes JG, Brooks MM, Singh S, Weissfeld LA. A likelihood ratio test for nested proportions. Statistics in Medicine. 2015;34(3):525-38. PMID:25394913. PMCID: PMC4289453. 

 

El Khoudary SR, Brooks MM, Thurston RC, Matthews KA. Lipoprotein subclasses and endogenous sex hormones in women at midlife. J Lipid Res. 2014 May 22;55(7):1498-1504. PMID: 24852168. PMCID: PMC4076076. 

 

Althouse AD, Abbott JD, Sutton-Tyrrell K, Forker AD, Lombardero MS, Buitrón LV, Pena-Sing I, Tardif JC, Brooks MM, BARI 2D Study Group. Favorable effects of insulin sensitizers pertinent to peripheral arterial disease in type 2 diabetes: results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Diabetes Care. 2013 Oct; 36 (10):3269-75. PMCID: PMC3781574. PMID: 23735723. 

 

Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H, Passano E, Hardison RM, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. American Heart Journal. 2013 Jun; 165 (6):964-971.e1. PMID: 23708168. 

 

Brooks MM, Chaitman BR, Nesto RW, Hardison RM, Feit F, Gersh BJ, Krone RJ, Sako EY, Rogers WJ, Garber AJ, King SB 3rd, Davidson CJ, Ikeno F, Frye RL, BARI 2D Study Group. Clinical and angiographic risk stratification and differential impact on treatment outcomes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2012 Oct 23; 126 (17):2115-24. PMID: 23008442. 

 

Cooper JN, Buchanich JM, Youk A, Brooks MM, Barinas-Mitchell E, Conroy MB, Sutton-Tyrrell K. Reductions in arterial stiffness with weight loss in overweight and obese young adults: potential mechanisms. Atherosclerosis. 2012 Aug; 223 (2):485-90. PMCID: PMC3411893. PMID: 22703865. 

 

Brooks MM, Chung SC, Helmy T, Hillegass WB, Escobedo J, Melsop KA, Massaro EM, McBane RD, Hyde P, Hlatky MA; the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study Group. Health Status After Treatment for Coronary Artery Disease and Type 2 Diabetes Mellitus in the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial. Circulation. 2010;122:1690-99. 

 

The BARI 2D Study Group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. New England Journal of Medicine. 2009; 360:2503-15. 

 

Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, Carrié D, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kähler J, Kelsey SF, King SB, Kosinski AS, Lopes N, McDonald KM, Rodriguez A, Serruys P, Sigwart U, Stables RH, Owens DK, Pocock SJ. Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials. Lancet. 2009; 4:373:1190-7. 

Maria Mori Brooks