Maria Mori Brooks, PhD

My research has focused on the design, conduct, and analysis of multicenter clinical trials and cohort studies.  Most of my work has involved the evaluation of treatments and risk factors in patients with coronary disease and diabetes and the epidemiology of cardiovascular diseases and women’s health. I am the Principal Investigator of the Coordinating Center of the Study of Women's Health Across the Nation (SWAN), a multi-racial/ethnic longitudinal cohort study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. In addition, I am the Principal Investigator of the Data Coordinating Center for the Myocardial Ischemia and Transfusion (MINT) trial, a multicenter randomized clinical trial evaluating transfusion strategies for patients with acute myocardial infarction and anemia. Over the years, I have collaborated on projected involving pulmonology, infectious diseases, genetics, and behavioral interventions. I serve as the Vice-Chair for Education for the Department of Epidemiology and teach advanced epidemiological methods.

1985 - Williams College, Williamstown, MA; BA, Mathematics, cum laude
1986 - Harvard University, Cambridge, MA; MA, Statistics
1991 - University of North Carolina, Chapel Hill, NC; PhD, Statistics

• 2012-Present: Epidemiology 2187, Epidemiological Methods 2
• 2007-2012: Epidemiology 2181, Epidemiological Methods 1

• Study of Women’s Health Across the Nation (SWAN) Coordinating Center. NIH/NIA, Maria Mori Brooks, PI
• Myocardial Ischemia and Transfusion (MINT) Data Coordinating Center. NIH/NHLBI, Maria Mori Brooks, PI
• Network Management Core (NEMO) for the Pulmonary Trials Cooperative, NIH/NHLBI, Stephen R. Wisniewski, PI 
• Does Plasma Reduce Bleeding in Patients Undergoing Invasive Procedures, NIH/NHLBI, Jeffrey Carson, PI 
• Treatment of Feeding Problems in Children with Autism. NIH/NIMH, Cynthia R. Johnson, PI
• Diabetes and Coronary Artery Disease Trials Collaboration, Gilead Sciences, Inc., Maria Mori Brooks, PI

Green DJ, Brooks MM, Burckart GJ, Chinnock RE, Canter C, Addonizio LJ, Bernstein D, Kirklin JK, Naftel DC, Girnita DM, Zeevi A, Webber SA. The Influence of Race and Common Genetic Variations on Outcomes After Pediatric Heart Transplantation. Am J Transplant. 2017 Jun;17(6):1525-1539. PMID: 27931092.

Matthews KA, El Khoudary SR, Brooks MM, Derby CA, Harlow SD, Barinas-Mitchell EJ, Thurston RC. Lipid Changes Around the Final Menstrual Period Predict Carotid Subclinical Disease in Postmenopausal Women. Stroke. 2017 Jan;48(1):70-76. PMID: 27909203.

Ikeno F, Brooks MM, Nakagawa K, Kim MK, Kaneda H, Mitsutake Y, Vlachos HA, Schwartz L, Frye RL, Kelsey SF, Waseda K, Hlatky MA; BARI-2D Study Group. SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial. J Am Coll Cardiol. 2017 Jan 31;69(4):395-403. PMID: 28126156.

Tepper PG, Brooks MM, Randolph JF Jr, Crawford SL, El Khoudary SR, Gold EB, Lasley BL, Jones B, Joffe H, Hess R, Avis NE, Harlow S, McConnell DS, Bromberger JT, Zheng H, Ruppert K, Thurston RC. Characterizing the trajectories of vasomotor symptoms across the menopausal transition. Menopause. 2016 Oct;23(10):1067-74. PMID:27404029

Mancini GB, Farkouh ME, Brooks MM, Chaitman BR, Boden WE, Vlachos H, Hartigan PM, Siami FS, Sidhu MS, Bittner V, Frye R, Fuster V. Medical Treatment and Revascularization Options in Patients With Type 2 Diabetes and Coronary Disease. Journal of the American College of Cardiology. 2016 Sep 6;68(10):985-95. PMID: 27585501

Bertolet M, Brooks MM, Bittner V. Tree-based identification of subgroups for time-varying covariate survival data. Statistical Methods Medical Research. 2016 Feb;25(1):488-501. PMID: 23070595. PMC Journal – In Process

Nguyen-Ha P, Howrie D, Crowley K, Vetterly CG, McGhee W, Berry D, Ferguson E, Polischuk E, Brooks MM, Goff J, Stillwell T, Darville T, Thompson AE, Levin JE, Michaels MG, Green M. A Quality Assessment of a Collaborative Model of a Pediatric Antimicrobial Stewardship Program. Pediatrics. 2016;137(5):e20150316. PMC Journal – In Process.

Everett BM, Brooks MM, Vlachos HE, Chaitman BR, Frye RL, Bhatt DL; BARI 2D Study Group. Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes. New England Journal of Medicine. 2015 Aug 13;373(7):610-20. doi: 10.1056/NEJMoa1415921. PMID: 26267622. PMCID: PMC4627639

Chen YF, Yabes JG, Brooks MM, Singh S, Weissfeld LA. A likelihood ratio test for nested proportions. Statistics in Medicine. 2015;34(3):525-38. PMID:25394913. PMCID: PMC4289453.

El Khoudary SR, Brooks MM, Thurston RC, Matthews KA. Lipoprotein subclasses and endogenous sex hormones in women at midlife. Journal of Lipid Research. 2014 May 22. PMID: 24852168.

Althouse AD, Abbott JD, Sutton-Tyrrell K, Forker AD, Lombardero MS, Buitrón LV, Pena-Sing I, Tardif JC, Brooks MM, BARI 2D Study Group. Favorable effects of insulin sensitizers pertinent to peripheral arterial disease in type 2 diabetes: results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Diabetes Care. 2013 Oct; 36 (10):3269-75. PMCID: PMC3781574. PMID: 23735723.

Johnson CR, Turner KS, Foldes E, Brooks MM, Kronk R, Wiggs L. Behavioral parent training to address sleep disturbances in young children with autism spectrum disorder: a pilot trial. Sleep Medicine. 2013 Oct; 14 (10):995-1004. PMCID: PMC3775974. PMID: 23993773.

Bach RG, Brooks MM, Lombardero M, Genuth S, Donner TW, Garber A, Kennedy L, Monrad ES, Pop-Busui R, Kelsey SF, Frye RL, BARI 2D Investigators. Rosiglitazone and outcomes for patients with diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2013 Aug 20; 128 (8):785-94. PMCID:PMC3816149. PMID: 23857320.

Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H, Passano E, Hardison RM, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. American Heart Journal. 2013 Jun; 165 (6):964-971.e1. PMID: 23708168.

Brooks MM, Chaitman BR, Nesto RW, Hardison RM, Feit F, Gersh BJ, Krone RJ, Sako EY, Rogers WJ, Garber AJ, King SB 3rd, Davidson CJ, Ikeno F, Frye RL, BARI 2D Study Group. Clinical and angiographic risk stratification and differential impact on treatment outcomes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2012 Oct 23; 126 (17):2115-24. PMID: 23008442.

Cooper JN, Buchanich JM, Youk A, Brooks MM, Barinas-Mitchell E, Conroy MB, Sutton-Tyrrell K. Reductions in arterial stiffness with weight loss in overweight and obese young adults: potential mechanisms. Atherosclerosis. 2012 Aug; 223 (2):485-90. PMCID: PMC3411893. PMID: 22703865.

Brooks MM, Chung SC, Helmy T, Hillegass WB, Escobedo J, Melsop KA, Massaro EM, McBane RD, Hyde P, Hlatky MA; the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study Group. Health Status After Treatment for Coronary Artery Disease and Type 2 Diabetes Mellitus in the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial. Circulation. 2010;122:1690-99.

Ohmann EL, Brooks MM, Webber SA, Girnita DM, Ferrell RE, Burckart GJ, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel DC, Zeevi A. Association of genetic polymorphisms and risk of late post-transplantation infection in pediatric heart recipients. Journal of Heart and Lung Transplantation. 2010 Dec; 29(12):1342-1351. PMID: 20869265; NIHMS226119

The BARI 2D Study Group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. New England Journal of Medicine. 2009; 360:2503-15.

Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, Carrié D, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kähler J, Kelsey SF, King SB, Kosinski AS, Lopes N, McDonald KM, Rodriguez A, Serruys P, Sigwart U, Stables RH, Owens DK, Pocock SJ. Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials. Lancet. 2009; 4:373:1190-7.