Anne B Newman, MD, MPH

Director, Center for Aging and Population Health

Distinguished Professor, Epidemiology

Professor, Medicine, and Clinical and Translational Science

Clinical Director, Clinical Director, Aging Institute, University of Pittsburgh/UPMC

Contact

511 Bellefield Professional Building
R-znvy: narjzna@cvgg.rqh
Primary Phone: 967-838-6326


Administrative Contacts

Research Assistant
Michelle Utz-Kiley
E-mail: meu2@pitt.edu
Primary Phone: 412-383-1302

 


Personal Statement

Dr. Newman's research focuses on aging, including the determinants of physical and cognitive function as well as successful aging and longevity. She has special expertise in the study of cardiovascular disease and aging and body composition, sarcopenia, and physical functioning. She is presently the Principal Investigator (PI) of several long term cohort studies and clinical trials in older adults funded by the National Institute on Aging (NIA) and the National Health Lung and Blood Institute.

Dr. Newman is Distinguished Professor of Epidemiology in the School of Public Health at the University of Pittsburgh with a secondary appointment in the Department of Medicine and with the Clinical and Translational Science Institute (CTSI) at the University of Pittsburgh. Dr. Newman is an elected member of the American Epidemiology Society (AES),  the American Association of Physicians (AAP) and the Delta Omega Honor Society in Public Health. Dr. Newman is certified by the American Board of Internal Medicine with added qualifications in geriatric medicine. She directs the Center for Aging and Population Health in the Graduate School of Public Health and is co-Director of an NIA National Service Award, directed by Dr. Elsa Strotmeyer, for training epidemiology doctoral and post-doctoral fellows in the Epidemiology of Aging. She also serves as Co-Director for the NIA funded Older Americans Independence Center in the Department of Medicine and is the Clinical Director of the Aging Institute of the University of Pittsburgh/UPMC.

 


Education

1987 | University of Pittsburgh, Pittsburgh, PA | MPH, Public Health
1985-1987 | Presbyterian University Hospital, Pittsburgh, PA | Fellowship Geriatric Medicine
1982-1985 | Presbyterian University Hospital, Pittsburgh, PA | Internship & Residency
1982 | University of Pittsburgh, Pittsburgh, PA | MD, Medicine
1978 | University of Pittsburgh, Pittsburgh, PA | BS, Biology


Teaching

EPI 2980 | Biology and Physiology of Aging
EPI 2900 | Advanced Epidemiology of Aging
EPI 2260 | Epidemiological Basis for Disease Control
EPI 2923 | Scientific Writing in Epidemiology   


Service

Dr. Newman is past Editor-in-Chief of the Journals of Gerontology: Medical Sciences, and remains an Associate Editor. She also serves on the editorial boards of several other journals. She is a frequent reviewer and advisory panel member for both NHLBI and NIA, including a current appointment to the NIA Board of Scientific Counselors and the Clinical Trials Advisory Panel.


Research Interests

 

  • Subclinical Cardiovascular Disease and Aging
  • Obesity, Sarcopenia and Aging
  • Healthy Aging and Biology of Aging
  • Clinical Trials and Aging

 


Research Support

Principal Investigator

  • Study of Muscle and Mobility with Aging (SOMMA) (2018-2024) (Multi-PI) NIH/NIA
  • The Long Life Family Study (2019-2014) (Multi-PI) NIH/NIA
  • Implications of Metabolism on Healthy Aging in African and Caucasian Americans: The Health ABC Study (2018-2023) (Multi-PI) NIH/NIA

Co-Investigator

  • Pittsburgh Older Americans Independence Center (2015-2025) NIA

  • Reducing Risk and Promoting Health in Community-Based Elders (2018-2022) NIDDK

  • Predictors and Determinants of Age-Related Changes in Resiliencies to Physical Stressors in Humans (Characterizing Resiliencies to Physical Stressors) (2017-2022) NIA

  • Longevity Consortium (2018-2023) NIA/CALPAC

  • Nitrite Therapy to Improve Mitochondrial Energetics (2019-2022) NIA

  • Non-Fracture Fall Injuries and Long-Term Geriatric Consequences in Older Women and Men from a Cross-Cohort Study (2019-2024) NIH/NIA

  • The relationship between blood based bioenergetics and muscle function, mobility, and aging (2021-2026) NIH 

Other

  • Training in the Epidemiology of Aging (Co-Director) (2021-2025) NIH/NIA

 


Selected Publications

 https://www.ncbi.nlm.nih.gov/myncbi/1NwrYNsGo3uwSc/bibliography/public/

Publications:

  1. 1.  Beavers DP, Kritchevsky SB, Gill TM, Ambrosius WT, Anton SD, Fielding RA, King AC, Rejeski WJ, Lovato L, McDermott MM, Newman AB, Pahor M, Walkup MP, Tracy RP, Manini TM. Elevated IL-6 and CRP levels are associated with incident self-reported major mobility disability: A pooled analysis of older adults with slow gait speed. J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2293-2299. doi: 10.1093/gerona/glab093. PMID: 33822946; PMCID: PMC8598983.

    2. Woods RL, Espinoza S, Thao LTP, Ernst ME, Ryan J, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks RE, Fitzgerald SM, Stocks NP, Williamson JD, McNeil JJ, Murray AM, Newman AB; ASPREE Investigator Group. Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):2007-2014. doi: 10.1093/gerona/glaa316. PMID: 33367621; PMCID: PMC8514067.

    3. Farsijani S, Xue L, Boudreau RM, Santanasto AJ, Kritchevsky SB, Newman AB. Body Composition by Computed Tomography vs Dual-Energy X-ray Absorptiometry: Long-Term Prediction of All-Cause Mortality in the Health ABC Cohort. J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2256-2264. doi: 10.1093/gerona/glab105. PMID: 33835154; PMCID: PMC8599045.

    4. Feitosa MF, Kuipers AL, Wojczynski MK, Wang L, Barinas-Mitchell E, Kulminski AM, Thyagarajan B, Lee JH, Perls T, Christensen K, Newman AB, Zmuda JM, Province MA. Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments. Circ Genom Precis Med. 2021 Jun;14(3):e003201. doi: 10.1161/CIRCGEN.120.003201. Epub 2021 Apr 12. PMID: 33844929;  PMCID: PMC8214825.

    5. Marron MM, Moore SC, Wendell SG, Boudreau RM, Miljkovic I, Sekikawa A, Newman AB. Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men. Geroscience. 2022 Apr;44(2):1083-1094. doi: 10.1007/s11357-021-00382-6. Epub 2021 May 15. PMID: 33991295;PMCID: PMC9135949.

    6.Cawthon PM, Patel SM, Kritchevsky SB, Newman AB, Santanasto A, Kiel DP, Travison TG, Lane N, Cummings SR, Orwoll ES, Duchowny KA, Kwok T, Hirani V, Schousboe J, Karlsson MK, Mellström D, Ohlsson C, Ljunggren Ö, Xue QL, Shardell M, Jordan JM, Pencina KM, Fielding RA, Magaziner J, Correa-de-Araujo R, Bhasin S, Manini TM. What Cut-Point in Gait Speed Best Discriminates Community-Dwelling Older Adults With Mobility Complaints From Those Without? A Pooled Analysis From the Sarcopenia Definitions and Outcomes Consortium. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):e321-e327. doi: 10.1093/gerona/glab183. PMID: 34166490; PMCID: PMC8436986.

    7.Renner SW, Qiao Y, Gmelin T, Santanasto AJ, Boudreau RM, Walston JD, Perls TT, Christensen K, Newman AB, Glynn NW; LLFS Research Group. Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study. Aging Clin Exp Res. 2021 Jul 1. doi: 10.1007/s40520-021-01923-x. Online ahead of print. PMID: 34196949;  PMCID: PMC8864668.

    8.Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins JL, Gonzalez JM, Fontanillas P, Claringbould A, Bakker OB, Sulem P, Walters RG, Terao C, Turon S, Horikoshi M, Lin K, Onland-Moret NC, Sankar A, Hertz EPT, Timshel PN, Shukla V, Borup R, Olsen KW, Aguilera P, Ferrer-Roda M, Huang Y, Stankovic S, Timmers PRHJ, Ahearn TU, Alizadeh BZ, Naderi E, Andrulis IL, Arnold AM, Aronson KJ, Augustinsson A, Bandinelli S, Barbieri CM, Beaumont RN, Becher H, Beckmann MW, Benonisdottir S, Bergmann S, Bochud M, Boerwinkle E, Bojesen SE, Bolla MK, Boomsma DI, Bowker N, Brody JA, Broer L, Buring JE, Campbell A, Campbell H, Castelao JE, Catamo E, Chanock SJ, Chenevix-Trench G, Ciullo M, Corre T, Couch FJ, Cox A, Crisponi L, Cross SS, Cucca F, Czene K, Smith GD, de Geus EJCN, de Mutsert R, De Vivo I, Demerath EW, Dennis J, Dunning AM, Dwek M, Eriksson M, Esko T, Fasching PA, Faul JD, Ferrucci L, Franceschini N, Frayling TM, Gago-Dominguez M, Mezzavilla M, García-Closas M, Gieger C, Giles GG, Grallert H, Gudbjartsson DF, Gudnason V, Guénel P, Haiman CA, Håkansson N, Hall P, Hayward C, He C, He W, Heiss G, Høffding MK, Hopper JL, Hottenga JJ, Hu F, Hunter D, Ikram MA, Jackson RD, Joaquim MDR, John EM, Joshi PK, Karasik D, Kardia SLR, Kartsonaki C, Karlsson R, Kitahara CM, Kolcic I, Kooperberg C, Kraft P, Kurian AW, Kutalik Z, La Bianca M, LaChance G, Langenberg C, Launer LJ, Laven JSE, Lawlor DA, Le Marchand L, Li J, Lindblom A, Lindstrom S, Lindstrom T, Linet M, Liu Y, Liu S, Luan J, Mägi R, Magnusson PKE, Mangino M, Mannermaa A, Marco B, Marten J, Martin NG, Mbarek H, McKnight B, Medland SE, Meisinger C, Meitinger T, Menni C, Metspalu A, Milani L, Milne RL, Montgomery GW, Mook-Kanamori DO, Mulas A, Mulligan AM, Murray A, Nalls MA, Newman A, Noordam R, Nutile T, Nyholt DR, Olshan AF, Olsson H, Painter JN, Patel AV, Pedersen NL, Perjakova N, Peters A, Peters U, Pharoah PDP, Polasek O, Porcu E, Psaty BM, Rahman I, Rennert G, Rennert HS, Ridker PM, Ring SM, Robino A, Rose LM, Rosendaal FR, Rossouw J, Rudan I, Rueedi R, Ruggiero D, Sala CF, Saloustros E, Sandler DP, Sanna S, Sawyer EJ, Sarnowski C, Schlessinger D, Schmidt MK, Schoemaker MJ, Schraut KE, Scott C, Shekari S, Shrikhande A, Smith AV, Smith BH, Smith JA, Sorice R, Southey MC, Spector TD, Spinelli JJ, Stampfer M, Stöckl D, van Meurs JBJ, Strauch K, Styrkarsdottir U, Swerdlow AJ, Tanaka T, Teras LR, Teumer A, Þorsteinsdottir U, Timpson NJ, Toniolo D, Traglia M, Troester MA, Truong T, Tyrrell J, Uitterlinden AG, Ulivi S, Vachon CM, Vitart V, Völker U, Vollenweider P, Völzke H, Wang Q, Wareham NJ, Weinberg CR, Weir DR, Wilcox AN, van Dijk KW, Willemsen G, Wilson JF, Wolffenbuttel BHR, Wolk A, Wood AR, Zhao W, Zygmunt M; Biobank-based Integrative Omics Study (BIOS) Consortium; eQTLGen Consortium; Biobank Japan Project; China Kadoorie Biobank Collaborative Group; kConFab Investigators; LifeLines Cohort Study; InterAct consortium; 23andMe Research Team, Chen Z, Li L, Franke L, Burgess S, Deelen P, Pers TH, Grøndahl ML, Andersen CY, Pujol A, Lopez-Contreras AJ, Daniel JA, Stefansson K, Chang-Claude J, van der Schouw YT, Lunetta KL, Chasman DI, Easton DF, Visser JA, Ozanne SE, Namekawa SH, Solc P, Murabito JM, Ong KK, Hoffmann ER, Murray A, Roig I, Perry JRB. Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021 Aug;596(7872):393-397. doi: 10.1038/s41586-021-03779-7. Epub 2021 Aug 4. PMID: 34349265;  PMCID: PMC7611832.

    9.Moffit RE, Qiao YS, Moored KD, Santanasto AJ, Lange-Maia BS, Cawthon PM, Goodpaster BH, Strotmeyer ES, Newman AB, Glynn NW. Estimating cardiorespiratory fitness in older adults using a usual-paced 400-m long-distance corridor walk. J Am Geriatr Soc. 2021 Nov;69(11):3328-3330. doi: 10.1111/jgs.17360. Epub 2021 Jul 16. PMID: 34269423;  PMCID: PMC8595496.

    10.Ryan J, Espinoza S, Ernst ME, Ekram ARMS, Wolfe R, Murray AM, Shah RC, Orchard SG, Fitzgerald S, Beilin LJ, Ward SA, Williamson JD, Newman AB, McNeil JJ, Woods RL. Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):19-26. doi: 10.1093/gerona/glab225. PMID: 34338761;  PMCID: PMC8751791.

    11.Yudkovicz JJ, Minster RL, Barinas-Mitchell E, Christensen K, Feitosa M, Barker MS, Newman AB, Kuipers AL. Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults. Sci Rep. 2021 Sep 9;11(1):17980. doi: 10.1038/s41598-021-97298-0. PMID: 34504188;  PMCID: PMC8429644.

    12.Drew DA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle AN, Fried LF, Sarnak M, Gutiérrez OM, Semba RD, Neyra JA. Soluble Klotho and Incident Hypertension. Clin J Am Soc Nephrol. 2021 Oct;16(10):1502-1511. doi: 10.2215/CJN.05020421. Epub 2021 Sep 23. PMID: 34556498; PMCID: PMC8498995.

    13.Zhang K, Lovasi GS, Odden MC, Michael YL, Newman AB, Arnold AM, Kim DH, Wu C. Association of Retail Environment and Neighborhood Socioeconomic Status with Mortality among Community-dwelling Older Adults in the US: Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2021 Oct 20:glab319. doi: 10.1093/gerona/glab319. Online ahead of print. PMID: 34669918.

    14.Wojczynski MK, Lin SJ, Sebastiani P, Perls TT, Lee J, Kulminski A, Newman A, Zmuda JM, Christensen K, Province MA. NIA Long Life Family Study: Objectives, Design, and Heritability of Cross Sectional and Longitudinal Phenotypes. J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):717-727. doi: 10.1093/gerona/glab333. PMID: 34739053; PMCID: PMC8974329.

    15.Espinoza SE, Woods RL, Ekram ARMS, Ernst ME, Polekhina G, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks R, Fitzgerald SM, Stocks NP, Chan A, McNeil JJ, Murray AM, Newman AB, Ryan J; ASPREE Investigator Group. The effect of low-dose aspirin on frailty phenotype and frailty index in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly study. J Gerontol A Biol Sci Med Sci. 2021 Nov 10:glab340. doi: 10.1093/gerona/glab340. Online ahead of print. PMID: 34758073.

    16.Glynn NW, Gmelin T, Renner SW, QiaoScM YS, Boudreau RM, Feitosa MF, Wojczynski MK, Cosentino S, Andersen SL, Christensen K, Newman AB; LLFS Research Group. Perceived Physical Fatigability Predicts All-Cause Mortality in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Dec 15:glab374. doi: 10.1093/gerona/glab374. Online ahead of print. PMID: 34908118.

    17.Xue L, Boudreau RM, Donohue JM, Zgibor JC, Marcum ZA, Costacou T, Newman AB, Waters TM, Strotmeyer ES. Persistent polypharmacy and fall injury risk: the Health, Aging and Body Composition Study.  BMC Geriatr. 2021 Dec 15;21(1):710. doi: 10.1186/s12877-021-02695-9. PMID: 34911467; PMCID: PMC8675466.

    18.Zhang L, Bartz TM, Santanasto A, Djoussé L, Mukamal KJ, Forman DE, Hirsch CH, Newman AB, Gottdiener JS, Kizer JR. Body Composition and Incident Heart Failure in Older Adults: Results From 2 Prospective Cohorts. J Am Heart Assoc. 2022 Jan 4;11(1):e023707. doi: 10.1161/JAHA.121.023707. Epub 2021 Dec 20. PMID: 34927442;  https://doi.org/10.1161/JAHA.121.023707.

    19.Cheng J, Burke LE, Venditti EM, Sereika SM, Glynn NW, Albert SM, Newman AB. Diet Improvements in Community-Dwelling Older Adults in the Mobility and Vitality Lifestyle Program. J Appl Gerontol. 2022 Feb 2:7334648211066916. doi: 10.1177/07334648211066916. Online ahead of print. PMID: 35109691.

    20.Neumann JT, Thao LTP, Callander E, Carr PR, Qaderi V, Nelson MR, Reid CM, Woods RL, Orchard SG, Wolfe R, Polekhina G, Williamson JD, Trauer JM, Newman AB, Murray AM, Ernst ME, Tonkin AM, McNeil JJ. A multistate model of health transitions in older people: a secondary analysis of ASPREE clinical trial data. Lancet Healthy Longev. 2022 Feb;3(2):e89-e97. doi: 10.1016/s2666-7568(21)00308-1. Epub 2022 Feb 7. PMID: 35224525; PMCID: PMC8880962.

    21.Bhatt SP, Balte PP, Schwartz JE, Jaeger BC, Cassano PA, Chaves PH, Couper D, Jacobs DR Jr, Kalhan R, Kaplan R, Lloyd-Jones D, Newman AB, O'Connor G, Sanders JL, Smith BM, Sun Y, Umans JG, White WB, Yende S, Oelsner EC. Pooled Cohort Probability Score for Subclinical Airflow Obstruction.  Ann Am Thorac Soc. 2022 Feb 17. doi: 10.1513/AnnalsATS.202109-1020OC. Online ahead of print. PMID: 35176216.

    22.Yousefi K, Ramdas KN, Ruiz JG, Walston J, Arai H, Volpi E, Newman AB, Wang C, Hitchinson B, McClain-Moss L, Diaz L, Green GA, Hare JM, Oliva AA. The Design and Rationale of a Phase 2b, Randomized, Double-Blinded, and Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Lomecel-B in Older Adults with Frailty. J Frailty Aging. 2022;11(2):214-223. doi: 10.14283/jfa.2022.2. PMID: 35441200 Clinical Trial.

    23. Wu C, Li YX, Marron MM, Odden MC, Newman AB, Sanders JL. Corrigendum to: Quantifying and Classifying Physical Resilience Among Older Adults: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2022 Apr 18:glac048. doi: 10.1093/gerona/glac048. Online ahead of print. PMID: 35435959.

    24. Neumann JT, Thao LTP, Murray AM, Callander E, Carr PR, Nelson MR, Wolfe R, Woods RL, Reid CM, Shah RC, Newman AB, Williamson JD, Tonkin AM, McNeil JJ; ASPREE investigators. Prediction of disability-free survival in healthy older people. Geroscience. 2022 Apr 14. doi: 10.1007/s11357-022-00547-x. Online ahead of print. PMID: 35420334.

     

    1.            Books and Book Chapters

    1. Odden MC, Sims KD, Newman AB. Demography and Epidemiology. In: Halter JB, Ouslander JG, Studenski S, High KP, Asthana S, Supiano MA, Ritchie CS, Schmader K. eds. Hazzard's Geriatric Medicine and Gerontology, 8e. McGraw Hill; 2022.

Anne B Newman