Anne B Newman, MD, MPH

Department Chair, Epidemiology

Katherine M. Detre Endowed Chair, Population Health Sciences

Director, Center for Aging and Population Health

Distinguished Professor, Epidemiology

Professor, Medicine, and Clinical and Translational Science

Clinical Director, Aging Institute of UPMC and Pitt

Contact

5126 Public Health
R-znvy: arjznan@rqp.cvgg.rqh
Primary Phone: 967-179-8501


Administrative Contacts

Departmental Administrative Assistant
Kerry Hanahan
E-mail: KMH231@pitt.edu
Primary Phone: 412-624-3056
 

Research Assistant
Michelle Utz-Kiley
E-mail: meu2@pitt.edu
Primary Phone: 412-383-1302

 


Personal Statement

Dr. Newman's research focuses on aging, including the determinants of physical and cognitive function as well as successful aging and longevity. She has special expertise in the study of cardiovascular disease and aging and body composition, sarcopenia, and physical functioning. She is presently the Principal Investigator (PI) of several long term cohort studies and clinical trials in older adults funded by the National Institute on Aging (NIA).

Dr. Newman is professor and chair of the Department of Epidemiology in the Graduate School of Public Health at the University of Pittsburgh with a secondary appointment in the Department of Medicine and with the Clinical and Translational Science Institute (CTSI) at the University of Pittsburgh. She was appointed to the Katherine M. Detre Endowed Chair of Population Health Science in the Graduate School of Public Health in June, 2014. Dr. Newman is an elected member of the American Epidemiology Society (AES),  the American Association of Physicians (AAP) and the Delta Omega Honor Society in Public Health. Dr. Newman is certified by the American Board of Internal Medicine with added qualifications in geriatric medicine. She directs the Center for Aging and Population Health in the Graduate School of Public Health which includes an NIA National Service Award for training epidemiology doctoral fellows in the Epidemiology of Aging. She also serves as Co-Director for the NIA funded Older Americans Independence Center in the Department of Medicine.

 


Education

1987 | University of Pittsburgh, Pittsburgh, PA | MPH, Public Health
1985-1987 | Presbyterian University Hospital, Pittsburgh, PA | Fellowship Geriatric Medicine
1982-1985 | Presbyterian University Hospital, Pittsburgh, PA | Internship & Residency
1982 | University of Pittsburgh, Pittsburgh, PA | MD, Medicine
1978 | University of Pittsburgh, Pittsburgh, PA | BS, Biology


Teaching

EPI 2980 | Biology and Physiology of Aging
EPI 2900 | Advanced Epidemiology of Aging
EPI 2260 | Epidemiological Basis for Disease Control


Service

Dr. Newman serves as Editor-in-Chief of the Journal of Gerontology: Medical Science and on the editorial boards of several other journals. She is a frequent reviewer and advisory panel member for both NHLBI and NIA, including a current appointment to the NIA Board of Scientific Counselors.


Research Interests

 

  • Subclinical Cardiovascular Disease and Aging
  • Obesity, Sarcopenia and Aging
  • Healthy Aging and Biology of Aging
  • Clinical Trials and Aging

 


Research Support

Principal Investigator

  • Study of Muscle and Mobility with Aging (SOMMA) (2018-2024) (Multi-PI) NIH/NIA
  • The Long Life Family Study (2019-2014) (Multi-PI) NIH/NIA
  • Implications of Metabolism on Healthy Aging in African and Caucasian Americans: The Health ABC Study (2018-2023) (Multi-PI) NIH/NIA

Co-Investigator

  • Pittsburgh Claude D. Pepper Older Americans Independence Center (2003-2020) NIH/NIA
  • ASPirin in Reducing Events in the Elderly eXTension (2019-2024) NIH
  • Molecular Transducers of Physical Activity Clinical Center (2016-2022) NIH
  • Peripheral Nerve Function Decline in an Aged Cohort Comprehensive Evaluation of Aging-Related Clinical Outcomes and Geroproteins (2016-2021) NIH/NIA
  • PRagmatic EValuation of evENTAnd Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) (2019-2026) NIH/NIA

Other

  • Training in the Epidemiology of Aging (Director) (2008-2021) NIH/NIA

 


Selected Publications

https://www.ncbi.nlm.nih.gov/sites/myncbi/anne.newman.1/bibliography/40342796/public/?sort=date&direction=descending

Publications:

1. Zhang Y, Vittinghoff E, Pletcher MJ, Allen NB, Zeki Al Hazzouri A, Yaffe K, Balte PP, Alonso A, Newman AB, Ives DG, Rana JS, Lloyd-Jones D, Vasan RS, Bibbins-Domingo K, Gooding HC, de Ferranti SD, Oelsner EC, Moran AE. Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events. J Am Coll Cardiol. 2019 Jul 23;74(3):330-341. doi: 10.1016/j.jacc.2019.03.529. PMID: 31319915  PMCID: PMC6764095 https://www.sciencedirect.com/science/article/pii/S0735109719352969?via%3Dihub

 2. Marron MM, Wojczynski MK, Minster RL, Boudreau RM, Sebastiani P, Cosentino S, Thyagarajan B, Ukraintseva SV, Schupf N, Christensen K, Feitosa M, Perls T, Zmuda JM, Newman AB; Long Life Family Study. Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism. Geroscience. 2019 Aug;41(4):383-393. doi: 10.1007/s11357-019-00086-y. Epub 2019 Jul 22. PMID: 31332674; PMCID: PMC6815318

3. Shaaban CE, Aizenstein HJ, Jorgensen DR, Mahbubani RLM, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C. Physical Activity and Cerebral Small Vein Integrity in Older Adults. Med Sci Sports Exerc. 2019 Aug;51(8):1684-1691. doi: 10.1249/MSS.0000000000001952. PMID: 30817709; PMCID: PMC6629486

4. Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC. Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.JAMA Netw Open. 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038; PMCID: PMC6686981

5. Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L. Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.J Am Geriatr Soc. 2019 Aug;67(8):1559-1564. doi: 10.1111/jgs.15928. Epub 2019 May 2. PMID: 31045254; PMCID: PMC6830521

6. Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nat Commun. 2019 Aug 14;10(1):3669. doi: 10.1038/s41467-019-11558-2. PMID: 31413261; PMCID: PMC6694136 

7. Inzitari M, Metti A, Rosano C, Udina C, Pérez LM, Carrizo G, Verghese J, Newman AB, Studenski S, Rosso AL. Qualitative neurological gait abnormalities, cardiovascular risk factors and functional status in older community-dwellers without neurological diseases: The Healthy Brain Project. Exp Gerontol. 2019 Sep;124:110652. doi: 10.1016/j.exger.2019.110652. Epub 2019 Jul 6. PMID: 31288087; PMC6690485

 8. Hengeveld LM, Wijnhoven HAH, Olthof MR, Brouwer IA, Simonsick EM, Kritchevsky SB, Houston DK, Newman AB, Visser M. Prospective Associations of Diet Quality With Incident Frailty in Older Adults: The Health, Aging, and Body Composition Study. J Am Geriatr Soc. 2019 Sep;67(9):1835-1842. doi: 10.1111/jgs.16011. Epub 2019 Jul 2. PMID: 31267522; PMCID: PMC6771787

9. Miller LM, Peralta CA, Fitzpatrick AL, Wu C, Psaty BM, Newman AB, Odden MC. The role of functional status on the relationship between blood pressure and cognitive decline: the Cardiovascular Health Study. J Hypertens. 2019 Sep;37(9):1790-1796. doi: 10.1097/HJH.0000000000002102. PMID: 31058794; PMCID: PMC6709980

10. Garg PK, Biggs ML, Barzilay J, Djousse L, Hirsch C, Ix JH, Kizer JR, Tracy RP, Newman AB, Siscovick DS, Mukamal KJ. Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study.Diab Vasc Dis Res. 2019 Sep;16(5):483-485. doi: 10.1177/1479164119847481. Epub 2019 May 8. PMID: 31064218; PMCID: PMC6697602

11. Duan-Porter W, Vo TN, Ullman K, Langsetmo L, Strotmeyer ES, Taylor BC, Santanasto AJ, Cawthon PM, Newman AB, Simonsick EM, Waters TM, Ensrud KE. Hospitalization-Associated Change in Gait Speed and Risk of Functional Limitations for Older Adults.J Gerontol A Biol Sci Med Sci. 2019 Sep 15;74(10):1657-1663. doi: 10.1093/gerona/glz027. PMID: 30715162; PMCID: PMC6748735

12. Pahor M, Anton SD, Beavers DP, Cauley JA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu CK, Lovato LC, Lu J, Manini TM, McDermott MM, Miller ME, Newman AB, Radziszewska B, Stowe CL, Tracy RP, Walkup MP, Wu SS, Ambrosius WT. Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.J Gerontol A Biol Sci Med Sci. 2019 Sep 15;74(10):1612-1619. doi: 10.1093/gerona/gly277. PMID: 30541065; PMCID: PMC6748815

13. Kuipers AL, Wojczynski MK, Barinas-Mitchell E, Minster RL, Wang L, Feitosa MF, Kulminski A, Thyagarajan B, Lee JH, Province MA, Newman AB, Zmuda JM; Long-Life Family Study. Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families.Atherosclerosis. 2019 Dec;291:19-26. doi: 10.1016/j.atherosclerosis.2019.10.008. Epub 2019 Oct 10. PMID: 31634740 [PubMed - in process]

14. Marron MM, Wendell SG, Boudreau RM, Clish CB, Santanasto AJ, Tseng GC, Zmuda JM, Newman AB. Metabolites associated with walking ability among the oldest old from the CHS All Stars study.J Gerontol A Biol Sci Med Sci. 2020 Jan 23. pii: glaa030. doi: 10.1093/gerona/glaa030. [Epub ahead of print] PMID: 31970383 [PubMed - as supplied by publisher]

15. Newman AB, Kritchevsky SB, Guralnik JM, Cummings SR, Salive M, Kuchel GA, Schrack J, Morris MC, Weir D, Baccarelli A, Murabito JM, Ben-Shlomo Y, Espeland MA, Kirkland J, Melzer D, Ferrucci L. Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):77-86. doi: 10.1093/gerona/glz230. PMID: 31722007 [PubMed - in process]

16. Oelsner EC, Balte PP, Bhatt SP, Cassano PA, Couper D, Folsom AR, Freedman ND, Jacobs DR Jr, Kalhan R, Mathew AR, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, White WB, Yende S. Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study.Lancet Respir Med. 2020 Jan;8(1):34-44. doi: 10.1016/S2213-2600(19)30276-0. Epub 2019 Oct 9. PMID: 31606435 [PubMed - in process]

17. Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB; Lifestyle Interventions and Independence for Elders Study Group. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.J Am Geriatr Soc. 2020 Mar;68(3):619-624. doi: 10.1111/jgs.16274. Epub 2019 Dec 22. PMID: 31867713 [PubMed - in process]

18. Chowdhury EK, Nelson MR, Ernst ME, Margolis KL, Beilin LJ, Johnston CI, Woods RL, Murray AM, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Abhayaratna WP, Stocks NP, Fitzgerald SM, Orchard SG, Trevaks RE, Donnan GA, Grimm R, McNeil J, Reid CM; ASPREE Investigator Group. Factors associated with treatment and control of hypertension in a healthy elderly population free of cardiovascular disease: a cross-sectional study.Am J Hypertens. 2020 Apr 1;33(4):350-361. doi: 10.1093/ajh/hpz192. PMID: 31807750 [PubMed - as supplied by publisher]

19. Balachandran A, Gundermann DM, Walkup MP, King AC, Ambrosius WT, Kritchevsky SB, Pahor M, Newman AB, Manini TM. Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.Med Sci Sports Exerc. 2020 Apr;52(4):859-867. doi: 10.1249/MSS.0000000000002195.  PMID: 31688650 [PubMed - as supplied by publisher]

20. Wu C, Li YX, Marron MM, Odden MC, Newman AB, Sanders JL. Quantifying and Classifying Physical Resilience among Older Adults: The Health, Aging, and Body Composition Study.J Gerontol A Biol Sci Med Sci. 2019 Oct 19. pii: glz247. doi: 10.1093/gerona/glz247. [Epub ahead of print] PMID: 31628840 [PubMed - as supplied by publisher]

21. Odden MC, Rawlings AM, Khodadadi A, Fern X, Shlipak MG, Bibbins-Domingo K, Covinsky K, Kanaya AM, Lee A, Haan MN, Newman AB, Psaty BM, Peralta CA. Heterogeneous Exposure Associations in Observational Cohort Studies: The Example of Blood Pressure in Older Adults.Am J Epidemiol. 2019 Oct 8. pii: kwz218. doi: 10.1093/aje/kwz218. [Epub ahead of print] PMID: 31595960 [PubMed - as supplied by publisher]

22. Pahor M, Guralnik JM, Anton SD, Ambrosius WT, Blair SN, Church TS, Espeland MA, Fielding RA, Gill TM, Glynn NW, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Williamson JD. Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability. J Am Geriatr Soc. 2020 Feb 27. doi: 10.1111/jgs.16365. [Epub ahead of print] Review. PMID: 32105353 [PubMed - as supplied by publisher]

23. Balte PP, Chaves PHM, Couper DJ, Enright P, Jacobs DR Jr, Kalhan R, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith BM, Smith LJ, White WB, Yende S, Oelsner EC. Association of Nonobstructive Chronic Bronchitis With Respiratory Health Outcomes in Adults. JAMA Intern Med. 2020 Mar 2. doi: 10.1001/jamainternmed.2020.0104. [Epub ahead of print] PMID: 32119036 [PubMed - as supplied by publisher]

24. Westbury LD, Syddall HE, Fuggle NR, Dennison EM, Cauley JA, Shiroma EJ, Fielding RA, Newman AB, Cooper C. Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study. Calcif Tissue Int. 2020 Jun;106(6):616-624. doi: 10.1007/s00223-020-00679-2. Epub 2020 Mar 3. PMID: 32125471; PMCID: PMC7188697.

25. Ryan J, Storey E, Murray AM, Woods RL, Wolfe R, Reid CM, Nelson MR, Chong TTJ, Williamson JD, Ward SA, Lockery JE, Orchard SG, Trevaks R, Kirpach B, Newman AB, Ernst ME, McNeil JJ, Shah RC; ASPREE Investigator Group. Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline. Neurology. 2020 Mar 25. pii: 10.1212/WNL.0000000000009277. doi: 10.1212/WNL.0000000000009277. [Epub ahead of print] PMID: 32213642 [PubMed - as supplied by publisher]

26. Odden MC, Rawlings AM, Arnold AM, Cushman M, Biggs ML, Psaty BM, Newman AB. Patterns of Cardiovascular Risk Factors in Old Age and Survival and Health Status at 90. J Gerontol A Biol Sci Med Sci. 2020 Apr 8. pii: glaa043. doi: 10.1093/gerona/glaa043. [Epub ahead of print] PMID: 32267489 [PubMed - as supplied by publisher]

27. Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB. Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2020 Apr 17;75(5):899-905. doi: 10.1093/gerona/glz124. PMID: 31086986 [PubMed - in process]

28. Drew DA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle AN, Fried LF, Sarnak M, Gutiérrez OM.  Fibroblast Growth Factor 23 and Blood Pressure in Older Adults: The Health, Aging, and Body Composition Study. Hypertension. 2020 May 18:HYPERTENSIONAHA12014703. doi: 10.1161/HYPERTENSIONAHA.120.14703. Online ahead of print.Hypertension. 2020.PMID: 32418499

29. Häberle AD, Biggs ML, Cushman M, Psaty BM, Newman AB, Shlipak MG, Gottdiener J, Wu C, Gardin JM, Bansal N, Odden MC. Level and change in N-terminal pro B-type Natriuretic Peptide and kidney function and survival to age 90. J Gerontol A Biol Sci Med Sci. 2020 May 17:glaa124. doi: 10.1093/gerona/glaa124. Online ahead of print.J Gerontol A Biol Sci Med Sci. 2020.PMID: 32417919

30. Shardell M, Drew DA, Semba RD, Harris TB, Cawthon PM, Simonsick EM, Kalyani RR, Schwartz AV, Kritchevsky SB, Newman AB. Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults. J Endocr Soc. 2020 Apr 30;4(5):bvz032. doi: 10.1210/jendso/bvz032. eCollection 2020 May 1.J Endocr Soc. 2020.PMID: 32405607; PMCID: PMC7209777.

31. Marron MM, Harris TB, Boudreau RM, Clish CB, Moore SC, Murphy RA, Murthy VL, Sanders JL, Shah RV, Tseng GC, Wendell SG, Zmuda JM, Newman AB. A metabolite composite score attenuated a substantial portion of the higher mortality risk associated with frailty among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2020 May 3:glaa112. doi: 10.1093/gerona/glaa112. Online ahead of print.J Gerontol A Biol Sci Med Sci. 2020.PMID: 32361748

Editorial:

1. Le Couteur DG, Anderson RM, Newman AB. COVID-19 is a disease of older people. J Gerontol A Biol Sci Med Sci. 2020 Mar 28. pii: glaa077. doi: 10.1093/gerona/glaa077. [Epub ahead of print] No abstract available. PMID: 32222763 [PubMed - as supplied by publisher]

2. Le Couteur DG, Anderson RM, Newman AB. Erratum to: COVID-19 Through the Lens of Gerontology. J Gerontol A Biol Sci Med Sci. 2020 Apr 17. pii: glaa080. doi: 10.1093/gerona/glaa080. [Epub ahead of print] No abstract available. PMID: 32302376 [PubMed - as supplied by publisher]

3.  Newman AB. James Edgar Paullin: Pioneer in Geriatrics and Gerontology.J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):115-116. doi: 10.1093/gerona/glz194. No abstract available. PMID: 31586187 PubMed - in process]

Letter:

1. Cawthon P, Orwoll E, Ensrud K, Cauley JA, Kritchevsky SB, Cummings SR, Newman A. Assessing the impact of the covid-19 pandemic and accompanying mitigation efforts on older adults. J Gerontol A Biol Sci Med Sci. 2020 Apr 20. pii: glaa099. doi: 10.1093/gerona/glaa099. [Epub ahead of print] No abstract available. PMID: 32307522 [PubMed - as supplied by publisher]

Comment:

1. Comment in: Bauchner H, Sharfstein J. A Bold Response to the COVID-19 Pandemic: Medical Students, National Service, and Public Health. JAMA. 2020 Apr 8. doi: 10.1001/jama.2020.6166. [Epub ahead of print] No abstract available. PMID: 32267488 [PubMed - as supplied by publisher]

Consortium:

1. Bhasin S, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, Magaziner JM, Newman AB, Kiel DP, Cooper C, Guralnik JM, Cauley JA, Arai H, Clark BC, Landi F, Schaap LA, Pereira SL, Rooks D, Woo J, Woodhouse LJ, Binder E, Brown T, Shardell M, Xue QL, DʼAgostino RB Sr, Orwig D, Gorsicki G, Correa-De-Araujo R, Cawthon PM. Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium. J Am Geriatr Soc. 2020 Mar 9. doi: 10.1111/jgs.16372. [Epub ahead of print] PMID: 32150289 [PubMed - as supplied by publisher]

Anne B Newman