Estradiol may influence association between HDL cholesterol, aortic calcification


HEALIO - High HDL cholesterol levels alone may not be cardioprotective for midlife women; estradiol may influence the risk for cardiovascular disease, according to data from the SWAN Heart study.

“Levels of endogenous estradiol may play an important role in cardioprotective associations of HDL cholesterol,” Samar R. El Khoudary, PhD, MPH, FAHA, associate professor of epidemiology in the Graduate School of Public Health at the University of Pittsburgh, told Healio. “In midlife women, the protective association of high levels of HDL cholesterol with lower risk of aortic calcification is only evident at higher levels of endogenous estradiol.”

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