Jian-Min Yuan

Contributions to Public Health

• I contributed significantly to the establishment and maintenance of two large longitudinal cancer epidemiology cohorts in China and Singapore in late 1980s and early 1990s, which have led many contributions to the field of cancer etiology and prevention research.
  • Yuan J-M, Ross RK, Wang XL, Gao YT, Henderson BE, Yu MC. Morbidity and mortality in relation to cigarette smoking in Shanghai, China. A prospective male cohort study. JAMA 275:1646-1650, 1996. PMID: 8637137
  • Yuan J-M, Ross RK, Gao YT, Henderson BE, Yu MC. Follow up study of moderate alcohol intake and mortality among middle aged men in Shanghai, China. BMJ 314:18-23, 1997. PMC2125578 DOI: 10.1136/bmj.314.7073.18
• I contributed significantly to the discovery of the carcinogenic role of dietary aflatoxin in the development of liver and gallbladder cancer.
  • Ross RK, Yuan J-M, Yu MC, Wogan GN, Qian GS, Tu JT, Groopman JD, Gao YT, Henderson BE. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet. 339:943-946, 1992. DOI: 10.1016/0140-6736(92)91528-g
  • Koshiol J, Zhu B, Wang R, Hildesheim A, Gao YT, Egner PA, Yuan J-M, Groopman JD. Association of aflatoxin with gallbladder cancer in a case-control study nested within a Chinese cohort. Int J Cancer 154:801-806, 2024. PMC10841509 DOI: 10.1002/ijc.34755
• I contributed significantly to the discovery of carcinogenic role of tobacco nitrosamine and their metabolizing genes the development of lung cancer in humans.
  • Yuan J-M, Koh WP, Murphy SE, Fan Y, Wang R, Carmella SG, Han S, Wickham K, Gao YT, Yu MC, Hecht SS. Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. Cancer Res. 69:2990-2995, 2009. PMC2664854 DOI: 10.1158/0008-5472.CAN-08-4330
  • Yuan J-M, Nelson HH, Carmella SG, Wang R, Kuriger-Laber J, Jin A, Adams-Haduch J, Hecht SS, Koh WP, Murphy SE. CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study. Carcinogenesis. 2017;38:411-418. PMC6248819 DOI: 10.1093/carcin/bgx012
• I contributed significantly to the evidence of protective effect of certain constituents in cruciferous vegetables against the development of lung cancer.
  • London SJ, Yuan J-M, Chung FL, Gao YT, Coetzee GA, Ross RK, Yu MC. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet. 356:724-729, 2000. DOI: 10.1016/S0140-6736(00)02631-3
  • Yuan J-M, Kensler TW, Dacic S, Hartman DJ, Wang R, Balogh PA, Sufka P, Turner MA, Fuhrer K, Seigh L, Pham YT, Adams-Haduch J, Valacchi G, Singh SV, Herman JG, Wilson DO. Randomized phase II clinical trial of sulforaphane in former smokers at high risk for lung cancer. Cancer Prev Res (Phila), 2025, DOI: 10.1158/1940-6207.CAPR-24-0386