Elsa S Strotmeyer

Contributions to Public Health

• Diabetes and neuromuscular impairments impact bone: My research showing type 2 diabetes associated with 64% higher fracture risk, independent of generally higher bone mineral density (BMD) and higher weight in older adults with type 2 diabetes, has been cited >400 times. I was the first to find bone loss associations with poor peripheral nerve function. I have a Multi-PI R01 on novel muscle associations with bone parameters from high resolution peripheral quantitative computed tomography (HR-pQCT).
  • Strotmeyer ES, Cauley JA, Schwartz AV, Nevitt MC, Resnick HE, Bauer DC, Tylavsky FA, de Rekeneire N, Harris TB, Newman AB. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the Health, Aging, and Body Composition Study. Arch Intern Med. 2005;25;165(14):1612-7.
  • Strotmeyer ES, Cauley JA, Schwartz AV, de Rekeneire N, Resnick HE, Zmuda JM, Shorr RI, Tylavsky FA, Vinik AI, Harris TB, Newman AB; Health ABC Study. Reduced peripheral nerve function is related to lower hip BMD and calcaneal QUS in older white and black adults: the Health, Aging and Body Composition Study. J Bone Miner Res. 2006;21(11):1803-10.
• Neuromuscular impairments are associated with disability and fall injuries: My R01 in the Health ABC Study utilized state-of-the art measures to capture sensory and motor nerve impairments associated with musculoskeletal function and mobility. My research established peripheral nerve impairments are common in older adults, and are a major risk factor for incident mobility disability and fall injuries in aging.
  • Ward RE, Boudreau RM, Caserotti P, Harris TB, Zivkovic S, Goodpaster BH, Satterfield S, Kritchevsky SB, Schwartz AV, Vinik AI, Cauley JA, Simonsick EM, Newman AB, Strotmeyer ES*; Health, Aging and Body Composition Study. Sensory and motor peripheral nerve function and incident disability. J Am Geriatr Soc. 2014;62(12):2273-9. PMCID:PMC4270855.
  • Winger ME, Caserotti P, Cauley JA, Boudreau RM, Piva SR, Cawthon PM, Orwoll ES, Ensrud KE, Kado DM, Strotmeyer ES*; Osteoporotic Fractures in Men (MrOS) Research Group. Lower leg power and grip strength are associated with increased fall injury risk in older men: the Osteoporotic Fractures in Men (MrOS) Study. J Gerontol A Biol Sci Med Sci. 2023 Mar 1;78(3):479-485. doi: 10.1093/gerona/glac122. PMID: 35662329; PMCID: PMC9977249.
• Diabetes, related metabolic factors and complications, predict physical performance: I found that peripheral nerve impairments are associated with muscle function and physical performance. My study described for the first time the longitudinal peripheral nerve decline with aging and identified novel modifiable risk factors such as the metabolic syndrome and renal function.
  • Lange-Maia BS, Newman AB, Cauley JA, Jakicic JM, Boudreau RM, Caserotti P, Glynn NW, Harris TB, Kritchevsky SB, Schwartz AV, Satterfield S, Simonsick EM, Vinik AI, Zivkovic S, Strotmeyer ES*. Sensorimotor peripheral nerve function and the longitudinal relationship with endurance walking in the Health, Aging and Body Composition Study. Arch Phys Med Rehabil. 2016;97(1):45-52. PMCID:PMC4696894.
  • Napoleone JM, Boudreau RM, Lange-Maia BS, El Khoudary SR, Ylitalo KR, Kriska AM, Karvonen-Gutierrez CA, Strotmeyer ES*. Metabolic syndrome trajectories and objective physical performance in mid-to-early late life: The Study of Women’s Health Across the Nation (SWAN). J Gerontol A Biol Sci Med Sci. 2021 Jul 3;glab188. doi: 10.1093/gerona/glab188. PMID: 34216218; PMCID: PMC8824556.
• Methods for neuromuscular function in old age: I developed and implemented physiologic assessments of neuromuscular function in aging for epidemiologic studies, including gold-standard measures in several randomized clinical trials and large epidemiologic studies for peripheral nerve assessment, and leg power tests including jump mechanography on a force plate and repeated stair climb laps. With these methods, I demonstrated that neuromuscular tests differentially associate with physical performance in aging.
  • Strotmeyer ES, Winger ME, Cauley JA, Boudreau RM, Cusick D, Collin RF, Chalhoub D, Buehring B, Orwoll E, Harris TB, Caserotti P. Normative values of muscle power using force plate jump tests in men aged 77-101 years: The Osteoporotic Fractures in Men (MrOS) Study. 2018;22(10):1167-1175. doi: 10.1007/s12603-018-1081-x. PMID: 30498822; PMCID: PMC8963464.
  • Winger ME, Caserotti P, Cauley JA, Boudreau RM, Piva SR, Cawthon PM, Harris TB, Barrett-Connor E, Fink HA, Kado DM, Strotmeyer ES*. Associations between novel jump test measures, grip strength, and physical performance: the Osteoporotic Fractures in Men (MrOS) Study. Aging Clin Exp Res. 2020 Apr;32(4):587-595. doi: 10.1007/s40520-019-01421-1. PMID: 31853832; PMCID: PMC7716274.