Bedda L Rosario

Contributions to Public Health

• My professional endeavors focus on design and analysis of both observational studies and randomized clinical trials. My research primarily addresses topics related to traumatic brain injury, neuroimaging, and trauma. I have many years of experience working in health sciences and neuroimaging fields.
• Trauma and Emergency Services: I am currently working with the Linking Investigations in Trauma and Emergency Services network where the goal is to conduct research on injury care and outcomes.
  • Van Gent, J. M., Clements, T. W., Rosario-Rivera, B. L., Wisniewski, S. R., Cannon, J. W., Schreiber, M. A., Moore, E. E., Namias, N., Sperry, J. L., & Cotton, B. A. (2025). The inability to predict futility in hemorrhaging trauma patients using 4-hour transfusion volumes and rates. The journal of trauma and acute care surgery, 98(2), 236–242. https://doi.org/10.1097/TA.0000000000004541.
  • Sperry, J. L., Guyette, F. X., Rosario-Rivera, B. L., Kutcher, M. E., Kornblith, L. Z., Cotton, B. A., Wilson, C. T., Inaba, K., Zadorozny, E. V., Vincent, L. E., Harner, A. M., Love, E. T., Doherty, J. E., Cuschieri, J., Kornblith, A. E., Fox, E. E., Bai, Y., Hoffman, M. K., Seger, C. P., Hudgins, J., … Cold Stored Platelet for Hemorrhagic Shock (CRISP-HS) Study Group (2024). Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial. Annals of surgery, 280(2), 212–221. https://doi.org/10.1097/SLA.0000000000006317.
• Pediatric Traumatic Brain Injury: I have collaborate with researchers at the University of Pittsburgh focusing on pediatric traumatic brain injury (TBI). These studies have applied advanced statistical analyses methods, including propensity score analysis and penalized regression, using observational data in order to reduce the bias due to confounding variables.
  • Bell, M. J., Rosario, B. L., Kochanek, P. M., Adelson, P. D., Morris, K. P., Au, A. K., Schober, M., Butt, W., Edwards, R. J., Zimmerman, J., Pineda, J., Le, T. M., Dean, N., Whalen, M. J., Figaji, A., Luther, J., Beers, S. R., Gupta, D. K., Carpenter, J., Buttram, S., … Approaches and Decisions for Acute Pediatric TBI (ADAPT) Investigators (2022). Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury. JAMA network open, 5(7), e2220969. https://doi.org/10.1001/jamanetworkopen.2022.20969
  • Rosario, B. L., Horvat, C. M., Wisniewski, S. R., Bell, M. J., Panigrahy, A., Zuccoli, G., Narayanan, S., Balasubramani, G. K., Beers, S. R., Adelson, P. D., & Investigators of the Cool Kids Trial (2018). Presenting Characteristics Associated With Outcome in Children With Severe Traumatic Brain Injury: A Secondary Analysis From a Randomized, Controlled Trial of Therapeutic Hypothermia. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 19(10), 957–964. https://doi.org/10.1097/PCC.0000000000001676
• Neuroimaging studies: I have made significant contributions to the field of neuroimaging, particularly in the areas of traumatic brain injury, aging, and Alzheimer’s disease. For these studies, I have applied advanced statistical analysis techniques on brain imaging data derived from MRI and PET, focusing on voxel-based analysis and region of interest analysis.
  • Ferrazzano, P. A., Rosario, B. L., Wisniewski, S. R., Shafi, N. I., Siefkes, H. M., Miles, D. K., Alexander, A. L., & Bell, M. J. (2019). Use of magnetic resonance imaging in severe pediatric traumatic brain injury: assessment of current practice. Journal of neurosurgery. Pediatrics, 23(4), 471–479. https://doi.org/10.3171/2018.10.PEDS18374
  • Rosario, B. L., Rosso, A. L., Aizenstein, H. J., Harris, T., Newman, A. B., Satterfield, S., Studenski, S. A., Yaffe, K., Rosano, C., & Health ABC Study (2016). Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(7), 968–973. https://doi.org/10.1093/gerona/glv224
• Longitudinal Data: I have applied statistical analysis to analyze longitudinal data (for normally distributed data or using transformations for non-normally distributed data) that included missing values and linear mixed models in several research areas including traumatic brain injury, insomnia, and imaging.
  • Clark RSB, Empey PE, Bayır H, Rosario BL, Poloyac SM, Kochanek PM, Nolin TD, Au AK, Horvat CM, Wisniewski SR, Bell MJ. Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children. PLoS One. 2017 Jul 7;12(7):e0180280. doi: 10.1371/journal.pone.0180280. PMID: 28686657; PMCID: PMC5501440.
  • Hasler BP, Martin CS, Wood DS, Rosario B, Clark DB. A longitudinal study of insomnia and other sleep complaints in adolescents with and without alcohol use disorders. Alcohol Clin Exp Res. 2014 Aug;38(8):2225-33. doi: 10.1111/acer.12474. Epub 2014 Jun 27. PMID: 24976511; PMCID: PMC4146702.

My Publications