The Cholera Epidemic of London, 1854
"You and I may not live to see the day, and my name may be forgotten when it comes, but the time will arrive when great outbreaks of cholera will be things of the past; and it is the knowledge of the way in which the disease is propagated which will cause them to disappear."
-John Snow to Henry Whitehead
John Snow conducted pioneering investigations on cholera epidemics in England, and particularly in London in 1854, during which he identified contaminated water as the key source of disease transmission.