Personal Statement
Dr. Reed did his doctoral work at the University of Texas Southwestern Medical Center at Dallas, working on thymocyte development in vitro. In 1995 Dr. Reed completed his dissertation and moved to Connecticut, where he worked as a postdoctoral fellow in the laboratory of Dr. Leo Lefrancois studying T lymphocyte activation in response to antigens entering through the small intestine. Dr. Reed became a principal investigator at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in 1999, developing animal models to aerosolized pathogens and conducting efficacy studies in those models. While at USAMRIID Dr. Reed conducted and supervised aerosol exposures of animals including rodents, rabbits, and nonhuman primates. Dr. Reed’s research at USAMRIID included developing nonhuman primate models of aerosol exposure to Venezuelan, Western, and Eastern Equine Encephalitis and evaluating candidate vaccines in those models, developing rodent and nonhuman primate models of aerosol exposure to Marburg and Ebola viruses, and evaluating a GMP-grade recombinant plague vaccine in mice against pneumonic plague. Dr. Reed is currently the Aerobiology Manager of the Regional Biocontainment Laboratory, working with collaborators to develop animal models of aerosol exposure to pathogens that are either biodefense threats or emerging infectious diseases.
My laboratory has ongoing research on three principal projects. First, we are working to understand the common pathological mechanisms of disease and host response to infection with intracellular bacterial pathogens including F. tularensis, B. pseudomallei, and Y. pestis. Second, working with Dr. Amy Hartman we are developing rodent and nonhuman primate models of aerosol exposure to Rift Valley Fever (RVF) virus and using those models to evaluate vaccines and therapeutics as well as to understand the pathophysiology of RVF. Third, as the manager of the Aerobiology Core I work with a number of external investigators to expose animals to aerosols containing pathogenic agents. That work includes model development including evaluation of immunological responses using flow cytometry and physiological responses using radiotelemetry.
Selected Publications
• Faith, S.A., Smith, L.P., Swatland, A.S., Reed, D.S. 2012. Growth conditions and environmental factors impact aerosolization but not virulence of Francisella tularensis infection in mice. Front Cell Inf Microbio. 2(126):1-10. PMID: 23087911
• Bales, J.M., Powell, D.S., Bethel, L.M., Reed, D.S., Hartman, A.L. 2012. Choice of inbred rat strain impacts lethality and disease course after respiratory infection with Rift Valley Fever virus. Front Cell Inf Microbio 2(105):1-14. PMID: 22919694
• Roy, C.J., Reed, D.S. 2012. Infectious disease aerobiology: miasma incarnate. Front Cell Inf Microbio. 2(163):1-2. PMID: 23267441
• Dupuy, L.C., Reed, D.S. 2012. Nonhuman Primate Models of Encephalitic Alphavirus Infection: Historical Review and Future Perspectives. Curr Opin Virol. 2(3):363-7 PMID: 22709522
• Reed DS, Smith L, Dunsmore T, Trichel A, Ortiz LA, Cole KS, Barry E. Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection. PLoS One. 2011;6(9):e24654. Epub 2011 Sep 13. PMID: 21931798
• Reed DS, Lackemeyer MG, Garza NL, Sullivan LJ, Nichols DK. Aerosol exposure to Zaire ebolavirus in three nonhuman primate species: differences in disease course and clinical pathology. Microbes Infect. 2011 May 25. [Epub ahead of print] PMID: 21651988
• Dupuy LC, Richards MJ, Reed DS, Schmaljohn CS. Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates. Vaccine. 2010 Oct 28;28(46):7345-50. Epub 2010 Sep 17. PMID: 20851089
• Alves DA, Glynn AR, Steele KE, Lackemeyer MG, Garza NL, Buck JG, Mech C, Reed DS. Aerosol exposure to the angola strain of marburg virus causes lethal viral hemorrhagic fever in cynomolgus macaques. Vet Pathol. 2010 Sep;47(5):831-51. PMID: 20807825
• Roy CJ, Reed DS, Hutt JA. Aerobiology and inhalation exposure to biological select agents and toxins. Vet Pathol. 2010 Sep;47(5):779-89. Epub 2010 Aug 3. Review. PMID: 20682804
• Roy CJ, Reed DS, Wilhelmsen CL, Hartings J, Norris S, Steele KE. Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs. Virol J. 2009 Oct 23;6:170. PMID: 19852817