Priscila M Da Silva Castanha

Contributions to Public Health

• Cutaneous immunity and pathogenesis of arboviruses
  • Castanha PM, Marti M, Duangkhae P, Taddonio J, Cooper K, Wallace M, Kettenburg G, Erdos G, Chavva H, Alex A, Rubin JP, Watkins SC, Falo LD Jr, Marques ET, Martinson J, Barratt-Boyes SM. (2025). Genetic ancestry shapes dengue virus infection in human skin explants. PNAS. In Press.
  • Castanha PMS, Azar SR, Yeung J, Wallace M, Kettenburg G, Watkins SC, Marques ETA, Vasilakis N, Barratt-Boyes SM. Aedes aegypti Mosquito Probing Enhances Dengue Virus Infection of Resident Myeloid Cells in Human Skin (2024). Viruses; 16(8):1253. PMID: 39205228.
• Antibody-mediated pathogenesis and immune interactions between arboviruses
  • Castanha PM, Erdos G, Watkins SC, Falo LD Jr, Marques ET, Barratt-Boyes SM. Reciprocal immune enhancement of dengue and Zika virus infection in human skin (2020). JCI Insight. PMID: 31910161.
  • Castanha PM, Braga C, Cordeiro MT, Souza AI, Silva CD Jr, Martelli CM, van Panhuis WG, Nascimento EJ, Marques ET. Placental Transfer of Dengue Virus (DENV)-Specific Antibodies and Kinetics of DENV Infection-Enhancing Activity in Brazilian Infants (2016). J Infect Dis.; 214(2): 265-72. PMID: 27056951.
• Humoral response and diagnostic tools for detection of arthropod-borne virus infections

  • Castanha PMS, McEnaney PJ, Park Y, Bouwer A, Chaves EJF, Lins RD, Paciaroni NG, Dickson P, Carlson G, Cordeiro MT, Magalhaes T, Craigo J, Marques ETA, Kodadek T, Burke DS. Identification and characterization of a nonbiological small-molecular mimic of a Zika virus conformational neutralizing epitope. PNAS. 2024; 121(21):e2312755121. PMID: 38743628.

  • Castanha PM, Souza W, Braga C, Araújo T, Ximenes RA, Albuquerque MFPM, Montarroyos UR, Miranda-Filho DB, Cordeiro MT, Dhalia R, Marques ETA Jr, Rodrigues LC, Martelli CMT. Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil (2019). PLoS Negl Trop Dis.; 13(3): e0007246. PMID: 30856223.

• Epidemiology and transmission dynamics of emerging and re-emerging viruses
  • Araújo TVB, Ximenes RAA, Miranda-Filho DB, Souza WV, Montarroyos UR, de Melo APL, Valongueiro S, de Albuquerque MFPM, Braga C, Filho SPB, Cordeiro MT, Vazquez E, Cruz DDCS, Henriques CMP, Bezerra LCA, Castanha PMDS, Dhalia R, Marques-Júnior ETA, Martelli CMT, Rodrigues LC. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study (2018). Lancet Infect Dis.; 18(3): 328-336. PMID: 29242091.
  • Castanha PMS, Montarroyos UR, Silveira SMM, Albuquerque GDM, Mello MJG, Lopes KGS, Cordeiro MT, Marques ETA, Martelli CMT, Braga C. Incidence and risk factors for Dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort (2017). Epidemiol Infect.; 145(14): 2971-2979. PMID: 28918772.
• Immunopathogenesis of emerging and re-emerging viral infections of global relevance
  • Castanha PMS, Tuttle DJ, Kitsios GD, Jacobs JL, Braga-Neto U, Duespohl M, Rathod S, Marti MM, Wheeler S, Naqvi A, Staines B, Mellors J, Morris A, McVerry BJ, Shah F, Schaefer C, Macatangay BJC, Methe B, Fernandez CA, Barratt-Boyes SM, Burke D, Marques ETA. Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019 (2022). J Infect Dis.; 226(5):766-777. PMID: 35267024.
  • Kanekiyo M, Gillespie RA, Cooper K, Canedo VG, Castanha PMS, Pegu A, Yang ES, Treaster L, Yun G, Wallace M, Kettenburg G, Williams C, Lundy J, Barrick S, O'Malley K, Midgett M, Martí MM, Chavva H, Corry J, Treat BR, Lipinski A, Batsche LO, Creanga A, Ritter I, Walker R, Olsen E, Laughlin A, Perez DR, Mascola JR, Boritz EA, Loo YM, Blair W, Esser M, Graham BS, Reed DS, Barratt-Boyes SM. Pre-exposure antibody prophylaxis protects macaques from severe influenza. Science. 2025 Jan 31;387(6733):534-541. doi: 10.1126/science.ado6481. Epub 2025 Jan 30. PMID: 39883776.

ORCID: 0000-0002-1220-5308