Oleksandr O Kapralov

Contributions to Public Health

• One of the focuses of my research is understanding of mechanisms of the involvement  of oxidative stress and lipid peroxidation in harmful effects of environmental pollutants leading to cell damages and development of diseases. I have contributed to research on nanotoxicology, focusing on how nano-objects interact with cells. Our work revealed that the enzyme myeloperoxidase can biodegrade carbon nanotubes, offering insight into reducing nanoparticle toxicity.
  • Kagan V.E., Konduru N.V., Feng W., Allen B.L., Conroy J., Volkov Y., Vlasova I.I., Belikova N.A., Yanamala N., Kapralov A., Tyurina Y.Y.., Shi J, Kisin E.R., Murray A.R., Franks J., Stolz D., Gou P., Klein-Seetharaman J., Fadeel B., Star A., Shvedova A.A. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation // Nat Nanotechnol. 2010;5(5):354-9. PMID:20364135
  • Shvedova AA, Kapralov AA, Feng WH, Kisin ER, Murray AR, Mercer RR, St Croix CM, Lang MA, Watkins SC, Konduru NV, Allen BL, Conroy J, Kotchey GP, Mohamed BM, Meade AD, Volkov Y, Star A, Fadeel B, Kagan VE. Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.
    PLoS One. 2012;7(3):e30923
• I was involved in developing o  potential therapeutic agents aimed at mitigating the harmful effects of ionizing radiation. This work has implications for both environmental health and emergency preparedness in radiation exposure scenarios.
  • Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun. 2011;2:497.  
  • Dar HH, Epperly MW, Tyurin VA, Amoscato AA, Anthonymuthu TS, Souryavong AB, Kapralov AA, Shurin GV, Samovich SN, St Croix CM, Watkins SC, Wenzel SE, Mallampalli RK, Greenberger JS, Bayır H, Kagan VE, Tyurina YY.P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis. JCI Insight. 2022 Feb 22;7(4):e156013. doi: 10.1172/jci.insight. 156013.
• My research helps to clarify involvement of oxidative stress and enzymatic lipid peroxidation  in development of ferroptosis—a form of cell death dependent on  presence of iron and lipid peroxidation.
  • Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stojanovski DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020 Mar;16(3):278-290. PMID:33679610
  • Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE.PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.Cell. 2017;171(3):628-641, PMID:29053969
• My current work is very important for establishing of the molecular links between environmental pollution, oxidative stress, and ferroptosis. It may help to develop approaches for better treatment of pollution-induced diseases and improvement of population health outcomes.