Guillermo Rodriguez Bey

Contributions to Public Health

• My research focuses on neurological pathologies, with an emphasis on exploring the intricate pathways that regulate gene expression associated with these conditions. To gain a comprehensive understanding, I employ a multidisciplinary approach using animal models (primarily mice), cell cultures, and human samples. This integrative strategy enables me to extract insights across different biological systems and levels of analysis.
• A core component of my work involves developing therapeutic strategies to alleviate symptoms of neurodegenerative diseases. By investigating signaling pathways and gene regulation at both the RNA and protein levels, I aim to uncover the fundamental molecular mechanisms that drive these disorders.
• Understanding these regulatory pathways is essential for identifying novel therapeutic targets and intervention and contribute to the creation of more effective treatments. My research not only deepens our understanding of the genetic and molecular basis of neurological diseases but also strives to translate these findings into tangible clinical benefits that improve patients' quality of life.
• Among my most significant contributions to the field are several key discoveries. I identified two distinct alleles linked to previously uncharacterized neurological diseases, expanding our understanding of genetic basis of pathology. I also discovered a potential therapeutic approach for amyotrophic lateral sclerosis (ALS), offering new hope for treatment. Additionally I identified a silencer element responsible for the pathology of adult-onset autosomal dominant leukodystrophy (ADLD), shedding light on the epigenetic mechanisms underlying this disease. These findings have not only advanced our scientific knowledge but also opened new avenues for future research and therapeutic innovation.