C. Elizabeth Shaaban

Contributions to Public Health

• Population neuroscience and public health: VCID and ADRD: I have made important contributions to the literature to make neuroimaging and dementia research more generalizable to older adults, something critical for public health. My work has covered common comorbidities of aging, pathophysiology, vascular and cardiometabolic risk factors, and joint effects of risk factors. I have also developed materials to introduce population neuroscience skills such as data harmonization to the next generation of researchers.
  • Shaaban CE, Rosso AL. (2024). Racial, Ethnic, and Geographic Diversity in Population Neuroscience. In: Paus T, Brooks J, Pausova Z, Keyes KM (eds). Principles and Advances in Population Neuroscience; Current Topics in Behavioral Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2024_475 PMCID: PMC11629388
  • Shaaban CE, Tudorascu DL, Glymour MM, Cohen AD, Thurston RC, Snyder HM, Hohman TJ, Mukherjee S, Yu L, Snitz BE. A Guide for Researchers Seeking Training in Retrospective Data Harmonization for Population Neuroscience Studies of Alzheimer’s Disease and Related Dementias. Frontiers in Neuroimaging. PMC10353763 https://doi.org/10.3389/fnimg.2022.978350
• Brain health equity - recruitment and representation science and social determinants of ADRD: This area of my work integrates my own research with practice carried out in my role as the Associate Outreach, Recruitment, and Engagement Core Director of the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC). I have carried out work assessing the association of the COVID pandemic with enrollment at the US ADRCs as well as work assessing social determinants of ADRD.
  • Shaaban CE, Lin HS, Terry M, Ren D, Lingler JH. COVID-19 pandemic's relationship with enrollment at US Alzheimer's Disease Research Centers. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024;20(4):2408-19. https://doi.org/10.1002/alz.13706. PMCID: PMC11032582.
  • Royse SK*, Snitz BE, Hengenius JB, Huppert TJ, Roush RE, Ehrenkranz RE, Wilson JD, Betolet M, Reese AC, Cisneros G, Potopenko K, Becker JT, Cohen AD^, Shaaban CE^. Unhealthy white matter connectivity in African American and non-Hispanic White older adults. 2024;20(3):1483-96. https://doi.org/10.1002/alz.13494 PMCID: PMC10947965; *=mentee; ^=co-senior authors.
• Novel neuroimaging approaches in population neuroscience: I have led efforts to develop and highlight novel neuroimaging methods and their applications in population neuroscience studies of ADRD. This includes methods to assess the tortuosity of deep medullary veins and a region-to-region spatially localized method of measuring white matter hyperintensities known as unhealthy white matter connectivity.
  • Shaaban, CE, Aizenstein, HJ, Jorgensen, DR, MacCloud, RL, Meckes, NA, Erickson, KI, Glynn, NW, Mettenburg, J, Guralnik, J, Newman, AB, Ibrahim, T S, Laurienti, PJ, Vallejo, AN, Rosano, C. In Vivo Imaging of Venous Side Cerebral Small-Vessel Disease in Older Adults: An MRI Method at 7T. AJNR Am J Neuroradiol. 2017. https://doi.org/10.3174/ajnr.A5327 PMCID: PMC5632121.
  • Royse SK*, Snitz BE, Hengenius JB, Huppert TJ, Roush RE, Ehrenkranz RE, Wilson JD, Betolet M, Reese AC, Cisneros G, Potopenko K, Becker JT, Cohen AD^, Shaaban CE^. Unhealthy white matter connectivity in African American and non-Hispanic White older adults. 2024;20(3):1483-96. https://doi.org/10.1002/alz.13494 PMCID: PMC10947965; *=mentee; ^=co-senior authors.
• Brain health equity - gender/sex, VCID, and ADRD: I have made important contributions to the literature on gender/sex differences in ADRD. This work has included evaluation of sex-specific dementia risk factors such as hypertensive disorders of pregnancy and placental small vessel disease, sex differences in AD pathology, and a culturally and globally informed perspective on gender/sex differences, gaps in knowledge, and recommendations for future research including in low- and middle-income countries.
  • Shaaban CE, Rosano C, Cohen AD, Huppert T, Butters MA, Hengenius J, Parks WT, Catov JM. Cognition and Cerebrovascular Reactivity in Midlife Women With History of Preeclampsia and Placental Evidence of Maternal Vascular Malperfusion. Front Aging Neurosci. 2021 May 4;13:637574. https://doi.org/10.3389/fnagi.2021.637574 PMCID: PMC8129174.
  • Mielke MM, Aggarwal NT, Vila-Castelar C, Agarwal P, Arenaza-Urquijo EM, Brett B, Brugulat-Serrat A, DuBose LE, Eikelboom WS, Flatt J, Foldi NS, Franzen S, Gilsanz P, Li W, McManus AJ, van Lent DM, Milani SA, Shaaban CE, Stites SD, Sundermann E, Suryadevara V, Trani JF, Turner AD, Vonk JMJ, Quiroz YT, Babulal GM; Diversity and Disparity Professional Interest Area Sex and Gender Special Interest Group. Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective. Alzheimers Dement. 2022 Dec;18(12):2707-2724. https://doi.org/10.1002/alz.12662  PMCID: PMC9547039. AWARD: International Society to Advance Alzheimer’s Research and Treatment Diversity and Disparities PIA 2023 Publication of the Year Award. AWARD: Alzheimer’s and Dementia Journal’s Top 10% Most Downloaded Articles, 2022.
• Intersectionality in dementia: I have made contributions to intersectional research in dementia considering race, ethnicity, gender/sex, life course financial mobility, and other factors. This work considers overlapping identities and systems of oppression stemming from sociocultural, political, environmental, and economic factors known as syndemic risk factors and their associations with dementia biomarkers, cognition, and risk and resilience to dementia.
  • Shaaban CE, Trani JF*, Babulal G*, for the Diversity and Disparities Professional Interest Area Sex and Gender Special Interest Group. *Co-Senior Authors, contributed equally. Integrating population neuroscience and syndemic frameworks to better understand sex and gender-differences cognitive disorders in aging globally. Alzheimer's Dement., 19: e074149. https://doi.org/10.1002/alz.074149. Poster presentation at AAIC July 2023.
  • Kobayashi LC, Peterson R, Avila-Rieger J, Amofa-Ho PA, Vila-Castelar C, Meza E, Shaaban CE, Gilsanz P, Mayeda ER. Life course financial mobility and later-life memory by gender and race/ethnicity: an intersectional analysis of a multi-ethnic cohort study. https://doi.org/10.1002/alz.078475  Presentation at AAIC July 2023.

My bibliography

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