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Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men...

Thursday 3/7 11:00AM - 12:00PM
4140 Public Health, Young Seminar Room

Presenter: Heng Bai

Paper: Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation

Authors:  Miroslav Balaz, Anton S. Becker, Lucia Balazova, ..., Matthias Johannes Betz, Irene A. Burger, Christian Wolfrum

Abstract:

Through genetic and pharmacological in vivo and in vitro approaches, Balaz et al. show that the mevalonate pathway is important for adipocyte browning. The importance of this pathway is supported by a retrospective clinical study and a small volunteer trial with fluvastatin. The authors identify geranylgeranyl pyrophosphate as the key mevalonate intermediate driving adipocyte browning.


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Last Updated On Friday, January 11, 2019 by Orbell, Adam W
Created On Friday, January 11, 2019

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