Presenter: Heng Bai
Paper: Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
Authors: Miroslav Balaz, Anton S. Becker, Lucia Balazova, ..., Matthias Johannes Betz, Irene A. Burger, Christian Wolfrum
Through genetic and pharmacological in vivo and in vitro approaches, Balaz et al. show that the mevalonate pathway is important for adipocyte browning. The importance of this pathway is supported by a retrospective clinical study and a small volunteer trial with fluvastatin. The authors identify geranylgeranyl pyrophosphate as the key mevalonate intermediate driving adipocyte browning.
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Last Updated On Friday, January 11, 2019 by Orbell, Adam W
Created On Friday, January 11, 2019
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