UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1988 World AIDS Day, IDM researcher Charles Rinaldo and dedicated local nurse Bridget Murtagh address HIV transmission, drug resistance, and the radically prescient question of whether HIV could be cured.
JOURNAL OF VIROLOGY - DeLucia, Rinaldo, and Rappocciolo show that efficiency of MΦ-mediated HIV trans infection of CD4+ T cells is a unique characteristic associated with control of disease progression, and it is impaired in HIV-infected NP. Their work demonstrates that the use of SIMV to decrease this mechanism of virus transfer should be considered for future HIV therapeutic development.
JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.
THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead.
PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified despite a high number of official dengue notifications in the area during this period. Here they show the important epidemiological features of these cas...
ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease.
JANE CAULEY, who has served as the associate dean for research, will be stepping down from that position to take on additional responsibilities as the executive vice chair of EPI. Cauley is also a distinguished professor of epidemiology. VELPANDI AYYAVOO, currently associate dean for faculty affairs and IDM professor, will become the associate dean for research and faculty affairs. Congratulations!
JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.
JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM interaction and downstream signaling cascades associated with synaptodendritic functions.
The MidAtlantic AIDS Education and Training Center hosted a conference that brought together regional experts to explore ways to increase awareness of the opioid and Hepatitis C epidemics affecting women and infants in Southwestern Pennsylvania. One outcome of note: they identified solutions to improve the current care model of clinical and behavioral health care for women of childbearing age who are opioid users.
SCIENTIFIC AMERICAN - Working with dendrites, what he calls "the quarterbacks of the immune system," IDM's ROBBIE MAILLIARD and colleagues are applying the budding field of TNT research to HIV. Now, they are investigating whether drugs that are commonly used to lower cholesterol levels could be repurposed to control viral infections.
NEW YORK TIMES - Researchers created a device that can test a drop of blood to tell, in about half an hour, who's immune to certain infections and who's not. The goal is to find groups of people at risk of outbreaks, especially in impoverished and remote areas, in time to save lives. "We need to develop cheaper and more efficient ways to detect outbreaks earlier," said IDM's ERNESTO MARQUES. “This may be one step in that direction.”
IDM's GIOVANNA RAPPOCCIOLO presented at the Conference on Retroviruses and Opportunistic Infections ion biomarkers and genetics of cell cholesterol dysregulation in HIV non-progressors. Co-authors include IDM faculty J MARTINSON and C RINALDO and recent doctoral graduate DIANA DELUCIA.
JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches to prevent and treat infection with highly pathogenic avian influenza viruses.