Directory Calendar News Careers Alumni Giving

Robert M Boudreau, PhD

Assistant Professor, Epidemiology


Core Dir for Biostatistics, Center for Aging and Population Health, Dept of Epidemiology, University of Pittsburgh, 130 N. Bellefield Avenue, Rm 513, Pittsburgh, PA 15213
R-znvy: ObhqernhE@rqp.cvgg.rqh
Primary Phone: 967-838-6859
Web site:

Personal Statement

Research Interests:
* Physiologic, subclinical, genetic, lifestyle and behavioral factors: Associations with healthy aging, disability  and frailty.
* Osteoarthritis (especially knee OA, MRI imaging), Osteoporosis.
* Longitudinal modeling and analysis of epidemiologic data.
* Quantification and statistical assessment of degree of mediation, confounding and effect modification in epidemiologic studies
* Medical outcomes risk-adjustment methods and health services research

My research interests are particularly focused on the application and development of methods for modeling longitudinal data, in hierarchical and mixed models, in cluster analysis and longitudinal latent class and mixture models, in the uses of administrative claims data for epidemiological and medical research and in the discovery and clear presentation of patterns through visualization of multi-dimensional data.


1973, Fairfield University, BS Mathematics
1986, University of Pittsburgh, PhD Statistics


EPIDEM 2180 – Epidemiological Methods 1    (Course director; co-instructor, guest lecturer)

EPIDEM 2850/CLRES 2095/Pharm 2003 - Introduction to Pharmacoepidemiology
    -  Regular expert guest lecture: "Confounding in Pharmacoepidemiology Studies"

EPIDEM 2900 - Advanced Epidemiology of Aging
    -  Regular expert guest lecture:  Analysis Issues in Studies of Aging

EPIDEM 2950 Epidemiology of Aging Seminar/Workshop

    - Regular expert guest lecture  (recent examples)

        9-30-2016    Time-varying Covariates in Cox Proportional Hazards Regression

        4-07-2017     Competing Risks Survival Analysis

      11-17-2017      Joint modeling of longitudinal and survival data

        3-16-2018     Testingfor mediation: Beyond the 10% attenuation criterion

Selected Publications

(Selection from 163 refereed articles)

1. Newman AB, Simonsick EM, Naydeck BL, Boudreau RM, Kritchevsky SB, Nevitt MC, Pahor M, Satterfield S, Brach JS, Studenski SA, Harris TB. Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. JAMA, 2006;295(17):2018-2026. PMID16670410.

2. Newman AB, Boudreau RM, Naydeck BL, Fried LF, Harris TB. A Physiologic Index of Comorbidity: Relationship to Mortality and Disability. J Gerontol Med Sci, 2008; 63A(6):603-609. PMC2496995.

3. Boudreau RM, Hanlon JT, Roumani YF, Studenski SA, Ruby CM, Wright RM, Hilmer SN, Shorr RI, Bauer DC, Simonsick EM, Newman AB.  Central nervous system medication use and mobility limitation in community elders: The Health, Aging and Body Composition Study.  Pharmacoepidemiol Drug Safety, 2009:18:916-922. PMC2904745.

4. Thompson LR, Boudreau R, Newman AB, Hannon MJ, Chu CR, Nevitt MC, Kwoh KC.The association of osteoarthritis risk factors with localized, regional and diffuse knee pain. Osteoarthritis Cartilage, 2010;18(10):1244-1249. PMC3132895.

5. Rosano C, Longstreth WT Jr, Boudreau R, Taylor CA, Du Y, Kuller LH, Newman AB. High blood pressure accelerates gait slowing in well-functioning older adults over 18-years of follow-up. J Am Geriatr Soc. 2011; 59(3):390-397. PMID21391929.

6. Sanders JL, Boudreau RM, Fried LP, Walston  JD, Harris TB, Newman AB.  Measurement of organ structure and function enhances understanding of the physiological  basis of frailty: the Cardiovascular Health Study. J Am Geriatr Soc. 2011; 59(9):1581-1588. PMID21883106.

7. Cauley  JA, Danielson ME, Boudreau R,  Barbour KE, Horwitz MJ, Bauer DC, Ensrud KE, Manson JE, Wactawski-Wende J,  Shikany JM, Jackson RD. Serum 25-hydroxyvitamin D and clinical fracture risk  in a multiethnic cohort of women: the Women's Health Initiative (WHI). J Bone Miner Res. 2011; 26(10):2378-88. PMID21710614.

8. Sanders JL, Boudreau RM, Penninx BW,  Simonsick EM, Kritchevsky SB, Satterfield S, Harris TB, Bauer DC, Newman AB;  for the Health ABC Study. Association of a Modified Physiologic Index with  Mortality and Incident Disability: The Health, Aging, and Body Composition  Study. J Gerontol A Biol Sci Med Sci.  67(12):1439-1446. PMID22546961.
9. Barbour  KE, Boudreau R, Danielson ME, Youk  AO, Wactawski-Wende J, Greep NC, Lacroix AZ, Jackson RD, Wallace RB, Bauer  DC, Allison MA, Cauley JA. Inflammatory markers and the risk of hip fracture:  The women's health initiative. J Bone  Miner Res. 2012; 27(5):1167-1176. PMID22392817.

10. White DK, Neogi T, Nevitt MC, Peloquin CE, Zhu Y, Boudreau RM, Cauley JA, Ferrucci L, Harris TB, Satterfield SM, Simonsick EM, Strotmeyer ES, Zhang Y. (2013) Trajectories of gait speed predict mortality in well-functioning older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 68(4):456-64. PMID23051974.

11, Lo-Ciganic WH, Boudreau RM, Gray SL, Zgibor JC, Donohue JM, Perera S, Newman AB, Simonsick EM, Bauer DC, Satterfield S, Hanlon JT. Changes in cholesterol-lowering medications use over a decade in community-dwelling older adults. Ann Pharmacother. 2013 Jul-Aug;47(7-8):984-92. PMID: 23780807

12. Kwoh K, Roemer FW, Hannon MJ, Moore CE, Jakicic JM, Guermazi A, Green SM, Evans RW, Boudreau R. Effect of oral glucosamine on joint structure in individuals with chronic knee pain: a randomized, placebo-controlled clinical trial. Arthritis Rheumatol. 2014 Apr;66(4):930-9. PMID: 24616448

13. Albert SM, King J, Boudreau R, Prasad T, Lin CJ, Newman AB. Primary prevention of falls: effectiveness of a statewide program. Am J Public Health. 2014 May;104(5):e77-84. PMID: 24625164

14..  Eckstein F, Boudreau RM,  Wang Z, Hannon MJ, Wirth W, Cotofana S, Guermazi A, Roemer F, Nevitt M, John  MR, Ladel C, Sharma L, Hunter DJ, Kwoh CK; for the OAI investigators.  Trajectory of Cartilage Loss within Four Years of Knee Replacement - A Nested  Case-Control Study from the Osteoarthritis Initiative. Osteoarthritis  Cartilage. 2014 Apr 29. pii: S1063-4584(14)01054-1. PMID: 24792212

15. Ward RE, Boudreau RM, Caserotti P, Harris TB, Zivkovic S, Goodpaster BH, Satterfield S, Kritchevsky SB, Schwartz AV, Vinik AI, Cauley JA, Simonsick EM, Newman AB, Strotmeyer ES; Health, Aging and Body Composition Study. Sensory and motor peripheral nerve function and incident mobility disability. J Am Geriatr Soc. 2014 Dec;62(12):2273-9. Erratum in: J Am Geriatr Soc. 2015 Mar;63(3):625. PMID: 25482096

16, Metti AL, Yaffe K, Boudreau RM, Simonsick EM, Carnahan RM, Satterfield S, Harris TB, Ayonayon HN, Rosano C, Cauley JA; Health ABC Study. Trajectories of inflammatory markers and cognitive decline over 10 years. Neurobiol Aging. 2014 Dec;35(12):2785-90. PMID: 24997674

 17. Smagula SF, Boudreau RM, Stone K, Reynolds CF 3rd, Bromberger JT, Ancoli-Israel S, Dam TT, Barrett-Connor E, Cauley JA; Osteoporotic Fractures in Men (MrOS) Research Group. Latent activity rhythm disturbance sub-groups and longitudinal change in depression symptoms among older men. Chronobiol Int. 2015;32(10):1427-37. PMID: 26594893 | PMCID: PMC4729211

 18. Singh J, Schupf N, Boudreau R, Matteini AM, Prasad T, Newman AB, Liu Y, Christensen K, Kammerer CM. Association of aging-related endophenotypes with mortality in 2 cohort studies: the Long Life Family Study and the Health, Aging and Body Composition Study. Am J Epidemiol. 2015 Dec 1;182(11):926-35. PMID: 26582777 | PMCID: PMC4668756 

 19. Best JR, Liu-Ambrose T, Boudreau RM, Ayonayon HN, Satterfield S, Simonsick EM, Studenski S, Yaffe K, Newman AB, Rosano C; Health, Aging and Body Composition Study. An Evaluation of the longitudinal, bidirectional associations between gait speed and cognition in older women and men. J Gerontol A Biol Sci Med Sci. 2016 Apr 10. PMID: 27069098

 20. Eckstein F, Boudreau R, Wang Z, Hannon MJ, Duryea J, Wirth W, Cotofana S, Guermazi A, Roemer F, Nevitt M, John MR, Ladel C, Sharma L, Hunter DJ, Kwoh CK; OAI Investigators. Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative. Eur Radiol. 2016 Jun;26(6):1942-51. PMID: 26376884 | PMCID: PMC4794411

 21.  Nadkarni NK, Boudreau RM, Studenski SA, Lopez OL, Liu G, Kritchevsky S, Yaffe K, Newman AB, Rosano C. Slow gait, white matter characteristics, and prior 10-year interleukin-6 levels in older adults.
Neurology. 2016 Nov 8;87(19):1993-1999. PMID: 27733566, PMCID: PMC5109955

 22 . Forman DE, Santanasto AJ, Boudreau R, Harris T, Kanaya AM, Satterfield S, Simonsick EM, Butler J, Kizer JR, Newman AB. Impact of Incident Heart Failure on Body Composition Over Time in the
Health, Aging, and Body Composition Study Population. Circ Heart Fail. 2017
Sep;10(9): PMID: 288999889.

23. Lunney JR, Albert SM, Boudreau R, Ives D, Satterfield S, Newman AB, Harris T; Health Aging and Body Composition Study. Mobility Trajectories at the End of Life: Comparing Clinical Condition and Latent Class Approaches. J Am Geriatr Soc. 2018 Mar;66(3):503-508. PMID: 2934575010.

24. Jammy GR, Boudreau RM, Singh T, Sharma PK, Ensrud K, Zmuda JM, Reddy PS, Newman AB, Cauley JA. Volumetric bone mineral density (vBMD), bone structure, and structural geometry
among rural South Indian, US Caucasian, and Afro-Caribbean older men. Arch Osteoporos. 2018 May 22;13(1):60. PMID: 29790041

Book Chapters

1.  Rao  CR, and Boudreau RM.  Diversity and Cluster Analyses of Blood Group Data on Some Human Populations.  In: Aravinda Chakravarti, ed.,  Human Population Genetics: The Pittsburgh Symposium. Van Nostrand Reinhold Press 1984;331-362.

2. Rao CR, and Boudreau RM.  Prediction of Future Observations in a  Factor Analytic Growth Model.  In: Krishnaiah PR ed.,  MultivariateAnalysis  VI: Proceedings of the Sixth International Symposium on Multivariate  Analysis.  North Holland Press 1985;449-466.

 3. Sanders  JL, Boudreau RM, Newman AB. Understanding the aging process using epidemiologic approaches. In: Newman AB and Cauley JA eds., The Epidemiology of  Aging. Springer, New York. 2013 Chptr 12:187-214.

Conference Oral Presentations (selected)

1. Boudreau R, Newman AB. Symposium: Random Spaghetti or Clumps?: A Cluster Analysis of Longitudinal Changes in Physiologic Systems in the Elderly to Identify Co-Stable Subgroups of Systems and Individuals Exhibiting the Healthiest Aging. Presented  at the Gerontological Society of America 62nd Annual Scientific Meeting, Atlanta,  GA, November 2009. The Gerontologist. 2009;49(S2):56.

2. Boudreau RM. Principal Trend Ratio Regression: Comparing Non-Linear Longitudinal Trajectories Between Groups via a Ratio Of Inter-period Changes When a Linear Trend Fits Poorly.  Session Title: Methods for Growth Curves and Trajectories - Contributed Papers.  Section on Statistics in Epidemiology. 2010 Joint Statistical Meetings, July 31-Aug 5, Vancouver, BC.

3. Boudreau RM, Hunter DJ, Wang Z, Roemer F, Eckstein F, Hannon MJ, Guermazi A, Kwoh CK. A
Virtual Knee Joint Replacement Clinical Endpoint Based on Longitudinal Trends and Thresholds in KOOS Knee Pain and Function in Osteoarthritis Initiative Participants. Arthritis Rheum 2012;64 Suppl 10:S1040.

4. Boudreau RM, Province MA, Elo IT, Sebastiani P, Newman AB, Hadley E. Predicting Future Longevity in LLFS Offspring based on the Cardiovascular Health Study (CHS) Cohort. Presented at the Gerontological Society of America 66th Annual Meeting. New Orleans, LA. The Gerontologist, 2013, 53(S1):506 

 5. O'Hare CJ, Kenny R, Rosano C, Boudreau R, Newman AB, Launer LJ, Yaffe K, Aizenstein HJ. Selected vascular risk factors and future cerebral blood flow in older adults. The Gerontologist (2015) 55 (Suppl2): 151.  Gerontological Society of America 68th Annual Scientific Meeting, Orland, FL, USA

 6. Jacob ME, Boudreau R, Sanders JL, Arnold A, Zgibor JC, Ganguli M, Albert SM, Newman AB. Can
late-life lifestyles impact end-of-life morbidity? [Symposium]. The Gerontologist (2015) 55 (Suppl 2):801.  Gerontological Society of America 68th Annual Scientific Meeting, Orland, FL, USA.

 7. Strotmeyer ES, Boudreau RM, Minion SC, Cauley JA, Donohue JM, Harris TB, Newman AB, Waters TM. Sensory nerve impairment is associated with higher total Medicare costs: the Health ABC Study. Gerontologist. 2016. 56 (Suppl 3). Gerontological Society of America 69th Annual Scientific Meeting, New Orleans, LA, USA.

8. Harris R, BoudreauRM, Strotmeyer ES, Brach J, Kwoh KC, Lane NE, Orwoll ES, Schwartz AV,
Cawthon PM, Cauley JA. The risk of fracture among men with sarcopenia and obesity and their combination, sarcopenic obesity: the MrOS Study. J Bone Miner Res. 2017. 32(S52). The American Society for Bone and Mineral Research 39th Annual Scientific Meeting, Denver, CO, USA.

Robert M Boudreau
© 2018 by University of Pittsburgh Graduate School of Public Health

Login  |  Sitemap