Anne B Newman, MD, MPH

Department Chair, Epidemiology

Katherine M. Detre Endowed Chair, Population Health Sciences

Director, Center for Aging and Population Health

Distinguished Professor, Epidemiology

Professor, Medicine, and Clinical and Translational Science

Clinical Director, Aging Institute of UPMC and Pitt

Contact

5126 Public Health
R-znvy: arjznan@rqp.cvgg.rqh
Primary Phone: 967-179-8501


Administrative Contacts

Departmental Administrator
Kerry Hanahan
E-mail: KMH231@pitt.edu
Primary Phone: 412-624-3056

Research Administrator
Michelle Utz-Kiley
E-mail: meu2@pitt.edu
Primary Phone: 412-383-1302

 


Personal Statement

Dr. Newman's research focuses on aging, including the determinants of physical and cognitive function as well as successful aging and longevity. She has special expertise in the study of cardiovascular disease and aging and body composition, sarcopenia, and physical functioning. She is presently the Principal Investigator (PI) of several long term cohort studies and clinical trials in older adults funded by the National Institute on Aging (NIA).

Dr. Newman is professor and chair of the Department of Epidemiology in the Graduate School of Public Health at the University of Pittsburgh with a secondary appointment in the Department of Medicine and with the Clinical and Translational Science Institute (CTSI) at the University of Pittsburgh. She was appointed to the Katherine M. Detre Endowed Chair of Population Health Science in the Graduate School of Public Health in June, 2014. Dr. Newman is an elected member of the American Epidemiology Society and the Delta Omega Honor Society in Public Health. Dr. Newman is certified by the American Board of Internal Medicine with added qualifications in geriatric medicine. She directs the Center for Aging and Population Health in the Graduate School of Public Health which includes a CDC Prevention Research Center and an NIA National Service Award for training epidemiology doctoral fellows in the Epidemiology of Aging. She also serves as co-PI for the NIA funded Older Americans Independence Center in the Department of Medicine.



Education

1987 | University of Pittsburgh, Pittsburgh, PA | MPH, Public Health
1985-1987 | Presbyterian University Hospital, Pittsburgh, PA | Fellowship Geriatric Medicine
1982-1985 | Presbyterian University Hospital, Pittsburgh, PA | Internship & Residency
1982 | University of Pittsburgh, Pittsburgh, PA | MD, Medicine
1978 | University of Pittsburgh, Pittsburgh, PA | BS, Biology


Teaching

EPI 2980 | Biology and Physiology of Aging
EPI 2900 | Advanced Epidemiology of Aging
EPI 2920 | Writing in Epidemiology: Manuscripts and Grants
EPI 2260 | Epidemiological Basis for Disease Control


Service

Dr. Newman serves as Associate Editor of the Journal of Gerontology: Medical Science and on the editorial boards of several other journals. She has long-standing service to NIH for grant review as a member of the Neurological Musculoskeletal and Aging Epidemiology Committee and as a member of several NIH monitoring boards for large cohort studies. She recently served on an Institute of Medicine’s Panel on the Adequacy of Evidence for Physical Guidelines, addressing guidelines for older adults.



Research Interests

  • Subclinical atherosclerosis: associations with aging, disability and frailty
  • Sarcopenia and disability
  • Healthy aging and longevity


Research Support

Principal Investigator

  • Lifestyle and Independence for the Elderly (LIFE) (2009-2016) NIA
  • ASPirin to Reduce Events in the Elderly (ASPREE) (2009-2016) NIA
  • The Long Life Family Study (2004-2019) NIA
  • The CHS All Stars Study (Exceptional Aging:12 Year Trajectories to function) (2004-2016) NIA
  • The Health, Aging and Body Composition Study (1996-2011) NIA
  • Center for Aging and Population Health – Prevention Research Center (CAPH-PRC) (2010-2015) CDC

Co-Principal Investigator

  • University of Pittsburgh Clinical Center for the Osteoarthritis Institute (2002-2013) NIAMS
  • Cardiovascular Health Study (CHS 1988-) NHLBI
  • Peripheral Nerve Function Decline in an Aged Cohort (2007-2012)
  • Brain Anatomical Correlates of Mobility Control in Oldest Old (2007-2012)
  • Study of Osteoporotic Fractures (SOF) – Pittsburgh Clinical Center – Renewal (2011-2016) NIA
  • Study of Osteoporotic Fractures in Men (MrOS) (2103-2018) NIA
  • Pittsburgh Older Americans Independence Center (2004-2014) NIA

Other

  • Training in the Epidemiology of Aging (Director) (2008-2010) NIH/NIA



Selected Publications

https://www.ncbi.nlm.nih.gov/sites/myncbi/anne.newman.1/bibliography/40342796/public/?sort=date&direction=descending

  1. Farsijani S, Santanasto A, Cawthon P, Boudreau R, Goodpaster B, Kritchevsky S, Harris T, Newman A. High Inter-muscular Fat Is Associated with Poor Mobility Function in Older Adults, Only When Accompanied by Low Muscle Area (P01-026-19). Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz028.P01-026-19. doi: 10.1093/cdn/nzz028.P01-026-19. eCollection 2019 Jun. PMID: 31223979; NePMCID: PMC6574145.
  2. Braganza AC, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S. Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight. 2019 May 23;5. pii: 128248. doi: 10.1172/jci.insight.128248. PMID: 31120438.
  3. Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB. Prevalence, Incidence and Risk Factors for Overall, Physical and Cognitive Independence among those from exceptionally long-lived families: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2019 May 14. pii: glz124. doi: 10.1093/gerona/glz124. [Epub ahead of print] PMID: 31086986.
  4. Garg PK, Biggs ML, Barzilay J, Djousse L, Hirsch C, Ix JH, Kizer JR, Tracy RP, Newman AB, Siscovick DS, Mukamal KJ. Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study. Diab Vasc Dis Res. 2019 May 8:1479164119847481. doi: 10.1177/1479164119847481. [Epub ahead of print] PMID: 31064218.
  5. Jung AY, Miljkovic I, Rubin S, Kritchevsky SB, Klepin HD, Newman AB, Cauley J, Ayonayon H, Harris TB, Murphy RA. Adherence to Cancer Prevention Guidelines among Older White and Black Adults in the Health ABC Study. Nutrients. 2019 May 3;11(5). pii: E1008. doi: 10.3390/nu11051008. PMID: 31058834.
  6. Miller LM, Peralta CA, Fitzpatrick AL, Wu C, Psaty BM, Newman AB, Odden MC. The role of functional status on the relationship between blood pressure and cognitive decline: the Cardiovascular Health Study. J Hypertens. 2019 May 1. doi: 10.1097/HJH.0000000000002102. [Epub ahead of print] PMID: 31058794.
  7. Marron MM, Harris TB, Boudreau RM, Clish CB, Moore SC, Murphy RA, Murthy VL, Sanders JL, Shah RV, Tseng GC, Wendell SG, Zmuda JM, Newman AB. Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men. Metabolites. 2019 Apr 30;9(5). pii: E83. doi: 10.3390/metabo9050083. PMID: 31052232.
  8. Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L. Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. J Am Geriatr Soc. 2019 May 2. doi: 10.1111/jgs.15928. [Epub ahead of print] PMID: 31045254.
  9. Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens C, Rivadeneira F, Kiel DP, Karasik D. Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry. J Bone Miner Res. 2019 Mar 19:e3698. doi: 10.1002/jbmr.3698. [Epub ahead of print] PMID: 30888730.
  10. Cawthon PM, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, Magaziner JM, Newman AB, Brown T, Kiel DP, Cummings SR, Shardel M, Guralnik J, Woodhouse LJ, Pahor M, Binder E, D'Agostino RB, Xue QL, Orwoll E, Landi F, Orwig D, Schaap L, Latham N NK, Hirani V, Kwok T, Pereira S, Rooks D, Kashiwa M, Torres-Gonzalez M, Menetski JP, Correa-De-Araujo R, Bhasin S; Sarcopenia Definition and Outcomes Consortium Conference participants. Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference. J Gerontol A Biol Sci Med Sci. 2019 Mar 14. pii: glz081. doi: 10.1093/gerona/glz081. [Epub ahead of print] PMID: 30869772.
  11. Shaaban CE, Aizenstein HJ, Jorgensen DR, Mahbubani RLM, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C. Physical Activity and Cerebral Small Vein Integrity in Older Adults. Med Sci Sports Exerc. 2019 Feb 26. doi: 10.1249/MSS.0000000000001952. [Epub ahead of print] PMID: 30817709.
  12. Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K. Discrepancy in Frailty Identification: Move beyond Predictive Validity. J Gerontol A Biol Sci Med Sci. 2019 Feb 21. pii: glz052. doi: 10.1093/gerona/glz052. [Epub ahead of print] PMID: 30789645.
  13. Newman AB. Plagiarism: Policy and Practice. J Gerontol A Biol Sci Med Sci. 2019 Feb 19. pii: glz046. doi: 10.1093/gerona/glz046. [Epub ahead of print] PMID: 30778523.
  14. Fanning J, Rejeski WJ, Chen SH, Nicklas BJ, Walkup MP, Axtell RS, Fielding RA, Glynn NW, King AC, Manini TM, McDermott MM, Newman AB, Pahor M, Tudor-Locke C, Miller ME; LIFE Study Investigators. A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 Feb 19. pii: glz050. doi: 10.1093/gerona/glz050. [Epub ahead of print] PMID: 30778518.
  15. Karasik D, Zillikens MC, Hsu YH, Aghdassi A, Akesson K, Amin N, Barroso I, Bennett DA, Bertram L, Bochud M, Borecki IB, Broer L, Buchman AS, Byberg L, Campbell H, Campos-Obando N, Cauley JA, Cawthon PM, Chambers JC, Chen Z, Cho NH, Choi HJ, Chou WC, Cummings SR, de Groot LCPGM, De Jager PL, Demuth I, Diatchenko L, Econs MJ, Eiriksdottir G, Enneman AW, Eriksson J, Eriksson JG, Estrada K, Evans DS, Feitosa MF, Fu M, Gieger C, Grallert H, Gudnason V, Lenore LJ, Hayward C, Hofman A, Homuth G, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Johnson T, Biffar R, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koller DL, Kooner JS, Kraus WE, Kritchevsky S, Kutalik Z, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Lerch MM, Lewis JR, Lill C, Lind L, Lindgren C, Liu Y, Livshits G, Ljunggren Ö, Loos RJF, Lorentzon M, Luan J, Luben RN, Malkin I, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Nethander M, Newman AB, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Peacock M, Perola M, Peters A, Prince RL, Psaty BM, Räikkönen K, Ralston SH, Ripatti S, Rivadeneira F, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schipf S, Shin CS, Smith AV, Smith SB, Soranzo N, Spector TD, Stancáková A, Stefansson K, Steinhagen-Thiessen E, Stolk L, Streeten EA, Styrkarsdottir U, Swart KMA, Thompson P, Thomson CA, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Uitterlinden AG, van Duijn CM, van Schoor NM, Vandenput L, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, J Wareham N, Waterworth D, Weedon MN, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Zhou Y, Nielson CM, Harris TB, Demissie S, Kiel DP, Ohlsson C. Disentangling the genetics of lean mass. Am J Clin Nutr. 2019;109(2):276-287. doi: 10.1093/ajcn/nqy272. PMID: 30721968.
  16. Duan-Porter W, Vo TN, Ullman K, Langsetmo L, Strotmeyer ES, Taylor BC, Santanasto AJ, Cawthon PM, Newman AB, Simonsick EM, Waters TM, Ensrud KE. Hospitalization-Associated Change in Gait Speed and Risk of Functional Limitations for Older Adults. J Gerontol A Biol Sci Med Sci. 2019 Feb 4. doi: 10.1093/gerona/glz027. [Epub ahead of print] PMID: 30715162.
  17. Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB; Long Life Family Study. A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity. Metabolism. 2019 Jan 30. pii: S0026-0495(19)30025-3. doi: 10.1016/j.metabol.2019.01.010. [Epub ahead of print] PMID: 30710575.
  18. McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe RS, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH; ASPREE Investigator Group. Baseline Characteristics of Participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 22. doi: 10.1093/gerona/gly278. [Epub ahead of print] PMID: 30668672.
  19. Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851. [Epub ahead of print] PMID: 30651383; PMCID: PMC6369905.
  20. Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019;104(1):112-138. doi: 10.1016/j.ajhg.2018.12.001. Epub 2018 Dec 27. PMID: 30595373; PMCID: PMC6323610.
  21. Lunney JR, Albert SM, Boudreau R, Ives D, Newman AB, Harris T. Fluctuating Physical Function and Health: Their Role at the End of Life. J Palliat Med. 2018 Dec 20. doi: 10.1089/jpm.2018.0289. [Epub ahead of print] PMID: 30570377.
  22. Wang HE, Donnelly JP, Yende S, Levitan EB, Shapiro NI, Dai Y, Zhao H, Heiss G, Odden M, Newman A, Safford M. Validation of the REGARDS Severe Sepsis Risk Score. J Clin Med. 2018;7(12). pii: E536. doi: 10.3390/jcm7120536. PMID: 30544923; PMCID: PMC6306847.
  23. Pahor M, Anton SD, Beavers DP, Cauley JA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu CK, Lovato LC, Lu J, Manini TM, McDermott MM, Miller ME, Newman AB, Radziszewska B, Stowe CL, Tracy RP, Walkup MP, Wu SS, Ambrosius WT; ENRGISE study investigators. Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2018 Dec 12. doi: 10.1093/gerona/gly277. [Epub ahead of print] PMID: 30541065.
  24. Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157; PMCID: PMC6277418.
  25. Odden MC, Koh WJH, Arnold AM, Rawlings AM, Psaty BM, Newman AB. Trajectories of Nonagenarian Health: Sex, Age, and Period Effects. Am J Epidemiol. 2019;188(2):382-388. doi: 10.1093/aje/kwy241. PMID: 30407481; PMCID: PMC6357807.
  26. Buford TW, Manini TM, Kairalla JA, McDermott MM, Vaz Fragoso CA, Chen H, Fielding RA, King AC, Newman AB, Tranah GJ. Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc. 2018;7(18):e010009. doi: 10.1161/JAHA.118.010009. PMID: 30371200; PMCID: PMC6222953.
  27. Liu Z, Hsu FC, Trombetti A, King AC, Liu CK, Manini TM, Fielding RA, Pahor M, Newman AB, Kritchevsky S, Gill TM; LIFE Study investigators. Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial. BMC Med. 2018;16(1):185. doi: 10.1186/s12916-018-1174-8. PMID: 30352583; PMCID: PMC6199791.
  28. Manini TM, Buford TW, Kairalla JA, McDermott MM, Vaz Fragoso CA, Fielding RA, Hsu FC, Johannsen N, Kritchevsky S, Harris TB, Newman AB, Cummings SR, King AC, Pahor M, Santanasto AJ, Tranah GJ. Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. Geroscience. 2018;40(5-6):497-511. doi: 10.1007/s11357-018-0043-x. Epub 2018 Oct 18. PMID: 30338417; PMCID: PMC6294723.
  29. Lai HT, de Oliveira Otto MC, Lemaitre RN, McKnight B, Song X, King IB, Chaves PH, Odden MC, Newman AB, Siscovick DS, Mozaffarian D. Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study. BMJ. 2018;363:k4067. doi: 10.1136/bmj.k4067. Erratum in: BMJ. 2018;363:k4445. PMID: 30333104; PMCID: PMC6191654.
  30. Sagawa N, Marcum ZA, Boudreau RM, Hanlon JT, Albert SM, O'Hare C, Satterfield S, Schwartz AV, Vinik AI, Cauley JA, Harris TB, Newman AB, Strotmeyer ES; Health Aging Body Composition Study. Low blood pressure levels for fall injuries in older adults: the Health, Aging and Body Composition Study. Eur J Ageing. 2018 Jan 19;15(3):321-330. doi: 10.1007/s10433-017-0449-9. eCollection 2018 Sep. PMID: 30310378; PMCID: PMC6156730.
  31. Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2018;73(11):1472-1481. doi: 10.1093/gerona/gly057. PMID: 30299504; PMCID: PMC6175028.
  32. Callahan KE, Lovato L, Miller ME, Marsh AP, Fielding RA, Gill TM, Groessl EJ, Guralnik J, King AC, Kritchevsky SB, McDermott MM, Manini T, Newman AB, Rejeski WJ. Self-Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc. 2018;66(10):1927-1933. doi: 10.1111/jgs.15468. Epub 2018 Oct 3. PMID: 30281796; PMCID: PMC6277208.
  33. Marron MM, Ives DG, Boudreau RM, Harris TB, Newman AB. Racial Differences in Cause-Specific Mortality Between Community-Dwelling Older Black and White Adults. J Am Geriatr Soc. 2018;66(10):1980-1986. doi: 10.1111/jgs.15534. Epub 2018 Sep 12. PMID: 30277581; PMCID: PMC6366626.
  34. McNeil JJ, Woods RL, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. Effect of Aspirin on Disability-free Survival in the Healthy Elderly. N Engl J Med. 2018;379(16):1499-1508. doi: 10.1056/NEJMoa1800722. Epub 2018 Sep 16. PMID: 30221596.
  35. McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med. 2018;379(16):1519-1528. doi: 10.1056/NEJMoa1803955. Epub 2018 Sep 16. PMID: 30221595.
  36. Cauley JA, Manini TM, Lovato L, Talton J, Anton SD, Domanchuk K, Kennedy K, Stowe CL, Walkup M, Fielding RA, Kritchevsky SB, McDermott MM, Newman AB, Ambrosius WT, Pahor M; ENRGISE Investigators. The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results. J Gerontol A Biol Sci Med Sci. 2018 Sep 8. doi: 10.1093/gerona/gly204. [Epub ahead of print] PMID: 30202946.
  37. Justice JN, Ferrucci L, Newman AB, Aroda VR, Bahnson JL, Divers J, Espeland MA, Marcovina S, Pollak MN, Kritchevsky SB, Barzilai N, Kuchel GA. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. Geroscience. 2018;40(5-6):419-436. doi: 10.1007/s11357-018-0042-y. Epub 2018 Aug 27. Review. PMID: 30151729; PMCID: PMC6294728.
  38. Tranah GJ, Katzman SM, Lauterjung K, Yaffe K, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR. Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality. Sci Rep. 2018;8(1):11887. doi: 10.1038/s41598-018-30255-6. PMID: 30089816; PMCID: PMC6082898.
  39. Demb J, Wei EK, Izano M, Kritchevsky S, Swede H, Newman AB, Shlipak M, Akinyemiju T, Gregorich S, Braithwaite D. Chronic inflammation and risk of lung cancer in older adults in the health, aging and body composition cohort study. J Geriatr Oncol. 2019;10(2):265-271. doi: 10.1016/j.jgo.2018.07.008. Epub 2018 Aug 3. PMID: 30078713.
  40. Nicholson CJ, Singh K, Saphirstein RJ, Gao YZ, Li Q, Chiu JG, Leavis P, Verwoert GC, Mitchell GF; AortaGen Consortium, Porter T, Morgan KG. Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces. J Am Heart Assoc. 2018;7(15). pii: e008926. doi: 10.1161/JAHA.118.008926. PMID: 30021807; PMCID: PMC6201469.
  41. Tranah GJ, Maglione JE, Yaffe K, Katzman SM, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR; Health, Aging and Body Composition Study. Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly. Int J Geriatr Psychiatry. 2018;33(10):1319-1326. doi: 10.1002/gps.4928. Epub 2018 Jul 8. PMID: 29984425.
  42. Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, Hankinson J, Jacobs DR Jr, Kalhan R, Kaplan R, Kronmal R, Lange L, Loehr LR, London SJ, Navas Acien A, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, Yeh F, Zhang Y, Moran AE, Mwasongwe S, White WB, Yende S, Barr RG. Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study. Am J Epidemiol. 2018 Nov 1;187(11):2265-2278. doi: 10.1093/aje/kwy139. PMID: 29982273; PMCID: PMC6211239.
  43. Albert SM, King J, Jones JR, Danielson ME, Park Y, Newman AB. Using the Infrastructure of State Aging Services to Promote Prevention Behavior. Prev Chronic Dis. 2018;15:E90. doi: 10.5888/pcd15.170567. PMID: 29981259; PMCID: PMC6040599.
  44. Christensen MA, Dixit S, Dewland TA, Whitman IR, Nah G, Vittinghoff E, Mukamal KJ, Redline S, Robbins JA, Newman AB, Patel SR, Magnani JW, Psaty BM, Olgin JE, Pletcher MJ, Heckbert SR, Marcus GM. Sleep characteristics that predict atrial fibrillation. Heart Rhythm. 2018 Sep;15(9):1289-1295. doi: 10.1016/j.hrthm.2018.05.008. Epub 2018 Jun 26. PMID: 29958805; PMCID: PMC6448388.
  45. Selamet U, Katz R, Ginsberg C, Rifkin DE, Fried LF, Kritchevsky SB, Hoofnagle AN, Bibbins-Domingo K, Drew D, Harris T, Newman A, Gutiérrez OM, Sarnak MJ, Shlipak MG, Ix JH. Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition Study. Am J Kidney Dis. 2018;72(3):419-428. doi: 10.1053/j.ajkd.2018.03.026. Epub 2018 Jun 6. PMID: 29885925; PMCID: PMC6245577.
  46. Moorthi RN, Doshi S, Fried LF, Moe SM, Sarnak MJ, Satterfield S, Schwartz AV, Shlipak M, Lange-Maia BS, Harris TB, Newman AB, Strotmeyer ES. Chronic kidney disease and peripheral nerve function in the Health, Aging and Body Composition Study. Nephrol Dial Transplant. 2019 Apr 1;34(4):625-632. doi: 10.1093/ndt/gfy102. PMID: 29757410; PMCID: PMC6452189.
  47. Chalhoub D, Boudreau R, Greenspan S, Newman AB, Zmuda J, Frank-Wilson AW, Nagaraj N, Hoffman AR, Lane NE, Stefanick ML, Barrett-Connor E, Dam T, Cawthon PM, Orwoll ES, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men. J Bone Miner Res. 2018 Sep;33(9):1612-1621. doi: 10.1002/jbmr.3458. Epub 2018 Jun 12. PMID: 29701926; PMCID: PMC6266871.
  48. Wu C, Geldhof GJ, Xue QL, Kim DH, Newman AB, Odden MC. Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results From 2 Large US Cohorts. Am J Epidemiol. 2018 Aug 1;187(8):1752-1762. doi: 10.1093/aje/kwy041. PMID: 29688247; PMCID: PMC6070050.
  49. Wu C, Newman AB, Dong BR, Odden MC. Index of Healthy Aging in Chinese Older Adults: China Health and Retirement Longitudinal Study. J Am Geriatr Soc. 2018 Jul;66(7):1303-1310. doi: 10.1111/jgs.15390. Epub 2018 Apr 23. PMID: 29684252.
  50. Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Kizer JR, Kaplan RC, Cappola AR, Cushman M, Jacob ME, Kritchevsky SB, Newman AB. Association of Biomarker and Physiologic Indices With Mortality in Older Adults: Cardiovascular Health Study.  J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):114-120. doi: 10.1093/gerona/gly075. PMID: 29659743; PMCID: PMC6298182.
  51. Baker JF, Newman AB, Kanaya A, Leonard MB, Zemel B, Miljkovic I, Long J, Weber D, Harris TB. The Adiponectin Paradox in the Elderly: Associations With Body Composition, Physical Functioning, and Mortality. J Gerontol A Biol Sci Med Sci.  2019 Jan 16;74(2):247-253. doi: 10.1093/gerona/gly017. PMID: 29438496; PMCID: PMC6333931.
  52. Murphy RA, Moore S, Playdon M, Kritchevsky S, Newman AB, Satterfield S, Ayonayon H, Clish C, Gerszten R, Harris TB. Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):73-80. doi: 10.1093/gerona/glx233.  PMID: 29186400; PMCID: PMC6298186.
  53. Chen W, Newman AB, Fried LF, Rifkin DE, Shlipak MG, Sarnak MJ, Katz R, Madero M, Raphael KL, Bushinsky DA, Ix JH. Relationship of acid-base status with arterial stiffness in community-living elders: the Health ABC Study. Nephrol Dial Transplant. 2018 Sep 1;33(9):1572-1579. doi: 10.1093/ndt/gfx292. PMID: 29177410; PMCID: PMC6113643.
  54. Best JR, Liu-Ambrose T, Metti AL, Rosso AL, Satterfield S, Studenski S, Newman AB, Rosano C; Health, Aging and Body Composition Study. Longitudinal Associations Between Walking Speed and Amount of Self-reported Time Spent Walking Over a 9-Year Period in Older Women and Men. J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1265-1271. doi: 10.1093/gerona/glx129. PMID: 28977349; PMCID: PMC6093379.
  55. Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM; LIFE Study Investigators . Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. J Gerontol B Psychol Sci Soc Sci. 2018 Oct 10;73(8):1501-1513. doi: 10.1093/geronb/gbx051. PubMed PMID: 28482106; PubMed Central PMCID: PMC6178963.
  56. Yeri A, Murphy RA, Marron MM, Clish C, Harris TB, Lewis GD, Newman AB, Murthy VL, Shah RV. Metabolite Profiles of Healthy Aging Index Are Associated With Cardiovascular Disease in African Americans: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):68-72. doi: 10.1093/gerona/glx232. PMID: 29253112; PMCID: PMC6298181.
  57. Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM; LIFE Study Investigators. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. J Gerontol B Psychol Sci Soc Sci. 2018;73(8):1501-1513. doi: 10.1093/geronb/gbx051. PMID: 28482106; PMCID: PMC6178963.
  58. Jacob ME, Marron MM, Boudreau RM, Odden MC, Arnold AM, Newman AB. Age, Race, and Gender Factors in Incident Disability. J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):194-197. doi: 10.1093/gerona/glx194. PMID: 29045556; PMCID: PMC5861898.
  59. Le Couteur DG, Anderson RM, Newman AB, de Cabo R. Stem Cell Transplantation for Frailty. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1503-1504. doi: 10.1093/gerona/glx158. Review. PMID: 29028259; PMCID: PMC6279163.
  60. Henderson RM, Miller ME, Fielding RA, Gill TM, Glynn NW, Guralnik JM, King A, Newman AB, Manini TM, Marsh AP, Pahor M, McDermott MM, Rejeski J, Tudor-Locke C, Kritchevsky SB; LIFE Study Investigators. Maintenance of Physical Function 1 Year After Exercise Intervention in At-Risk Older Adults: Follow-up From the LIFE Study. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):688-694. doi: 10.1093/gerona/glx231. PMID: 29490012; PMCID: PMC5905630.
  61. Rejeski WJ, Walkup MP, Fielding RA, King AC, Manini T, Marsh AP, McDermott M, Miller EY, Newman AB, Tudor-Locke C, Axtell RS, Miller ME; LIFE Study Investigators. Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):660-667. doi: 10.1093/gerona/glx132. PMID: 28977340; PMCID: PMC5905614.
  62. Hengeveld LM, Wijnhoven HAH, Olthof MR, Brouwer IA, Harris TB, Kritchevsky SB, Newman AB, Visser M; Health ABC Study. Prospective associations of poor diet quality with long-term incidence of protein-energy malnutrition in community-dwelling older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2018 Feb 1;107(2):155-164. doi: 10.1093/ajcn/nqx020. PMID: 29529142; PMCID: PMC6248415.

Anne B Newman