Lyndsay Avery's Dissertation, Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion, includes findings that have significant implications for the development of anti-Tim-3 antibodies as therapeutic agents.
Parichat Duangkhae's Dissertation, Defining Dengue Virus Infection in Human Skin, may provide a mechanism for the epidemiologic observation that African ancestry protects against severe dengue. Her findings highlight the importance of skin and the complex interplay between resident and immune skin cell populations in DENV infection and dengue pathogenesis.
Diana's dissertation, Cellular cholesterol regulation of HIV-1 trafficking during macrophage-mediated trans infection, suggests that targeting the ability of MΦ to drive HIV-1 dissemination in trans could significantly enhance HIV-1 therapeutic strategies.
Ben's dissertation, Use of Integrase Inhibitor to Assess the Cytotoxic T Lymphocyte Response During Simian Immunodeficiency Virus Infection in Rhesus Macaques, hopes to aid in the hunt for an elusive vaccine and/or cure against HIV by showing CD8+ cells kill cells containing virus prior to integration.
The schedule of defenses in the Department of Infectious Diseases and Microbiology is maintained by:
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