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Frank addresses surgeon general report on opioid epidemic (video)

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WPXI - "We've got to increase public health awareness of addiction. A lot of people think, 'It's not my family, it's not me, it's not my community,' and we know that it can be anybody." IDM's LINDA FRANK talks to NIGHTTalk about opioid addiction in Pittsburgh and around the country.  

2017 faculty and staff Delta Omega initiates

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The following four individuals will be inducted into the Omicron chapter of the Delta Omega Honorary Society at the Graduate School of Public Health, recognizing merit and encouraging further excellence in, and devotion to, public health work: Nancy W. Glynn (EPI '94), faculty and alumna; Leah M. Lamonte (IDM '06), alumna; Natalie A. Solomon-Brimage (BCHS '06), alumna; Christopher A. Taylor (EPI '10), alumnus. 

Rotarian director talks with Salk and Burke about polio eradication (video)

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A round-table was held today with some amazing minds on the issue of polio eradication: Jennifer Jones, director of Rotary International; PETER SALK, IDM visiting professor and son of research pioneer Jonas Salk; and DONALD BURKE, school dean and University associate vice chancellor of global health. Rotary has been raising awareness that "We are this close to ending polio!" While all were in Pittsburgh, they shared amazing conversation about the... 

IDM's Peter Salk on importance of Julius Youngner, polio vaccine pioneer, dead at 96

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NEW YORK TIMES - “I think it’s absolutely fair to say that had it not been for Dr. Youngner, the polio vaccine would not have come into existence,” PETER SALK president of the Jonas Salk Legacy Foundation and a visiting professor at the University of Pittsburgh Graduate School of Public Health, said in an e-mail. He added, “The really important thing to recognize is that the development of the polio vaccine at the University of Pittsburgh was a t... 

IDM's DELUCIA, RAVIKUMAR, and WOELL bring home 2017 Dean's Day departmental awards

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IDM awarded departmental prizes in the 2017 Dean's Day student research competition to DANA WOELL of the MPH-PEL program in the MPH category, PRANALI RAVIKUMAR in the MS category, and DIANA DELUCIA in the PhD category. 

IDM students and faculty participate in March for Science

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IDM students and faculty were among the thousands to participate in March for Science events held on April, 22, 2017 in Oakland (adjacent to the Pitt campus) and in Washington, DC. These nonpartisan event sought to celebrate the role that science plays in our everyday lives. 

Marques offers insignt as Zika season approaches

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TRIB LIVE - In the U.S., there have been 5,264 Zika cases reported, with the vast majority in travelers returning from affected areas in other countries, says ERNESTO MARQUES, associate professor with Pitt Public Health and scientific director of CURA ZIKA, an international alliance with counterparts in Brazil to help fundraising for research into the virus. Learn more about Cura Zika at www.publichealth.pitt.edu/curazika. 

Marques looks for clues to Zika damage in twins

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NEW YORK TIMES - Determining why one twin becomes infected in the womb while the other does not may illuminate how Zika crosses the placenta, how it enters the brain, and whether any genetic mutations make a fetus more resistant or susceptible to Zika infection. Perhaps the virus entered through a weak spot in one placenta’s membrane, said ERNESTO MARQUES, an infectious disease expert at Pitt Public Health and the Oswaldo Cruz Foundation in Recif... 

2017 IDM grad Noah Salama heading to Rochester for MD/PhD

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Congratulations to NOAH SALAMA (IDM '17) on his recent acceptance into University of Rochester's 8-year MD/PhD program. As a Pitt MS student, Salama worked with Dr. Amy Hartman on research into viral immune response. His thesis was entitled "Analysis of Peripheral Immune Responses for the Development of an NHP Animal Model for Encephalitic Alphaviruses EEEV, VEEV, and WEEV." 

Study by IDM's Mellors provides new understanding of HIV infections

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A new study represents an important advance toward better treatments and even a cure. “The immune system stays activated, angry, upset and inflamed despite current treatments, and that’s not good,” said study leader JOHN MELLORS of infectious diseases and microbiology. The research, involving various research centers including the National Institute of Allergy and Infectious Diseases, counters the idea “that inflammation and immune-cell activati... 

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Recent IDM Publications

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells 

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells

NATURE MEDICINE - Gupta, Sanyal, Ratner, Ding, Zerbato, Giacobbi, Venkatachari, Patterson, Chargin, Chen, Mailliard, Rinaldo, and Sluis-Cremer found that the size of the inducible latent HIV-1 reservoir in aviremic subjects on ART is approximately 70-fold larger than previous estimates.  (02/08/2018)

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IDM Videos

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IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO) 

IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO)

UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1998 World AIDS Day, Pitt IDM AIDS researcher Charles Rinaldo and the late Bridget Murtagh of th... (07/17/2018)
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Matthews on why we need a public health approach to HIV (video) 

Matthews on why we need a public health approach to HIV (video)

IDM's DERRICK MATTHEWS explains Pitt Public Health's work on HIV/AIDS and where we are today. "If your’e a black gay man in the U.S., you have a one in two change in your lifetime of becoming HIV positive…short of the cure that we’re looking for, the biology is way ahead of the social implementat... (06/20/2018)
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Matthews discusses the fields of infectious diseases and microbiology (IDM) (video) 

Matthews discusses the fields of infectious diseases and microbiology (IDM) (video)

IDM's DERRICK MATTHEWS demystifies infectious diseases and microbiology with a basic overview of the fields, how they are practiced, and how disease is spread.  (06/19/2018)
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Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO) 

Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO)

Doctoral candidate, DIANA DeLUCIA (IDM '19), presented some of her dissertation research on how the cholesterol levels in immune cells might be impacting HIV infection and disease progression to AIDS. It was found that antigen-presenting cells in nonprogressors have lower cholesterol levels which i... (04/19/2018)
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