IDM Department News

Di, Deslouches, and Montelaro develop promising antibiotic molecule for drug-resistant infections

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CISTIC FIBROSIS NEWS TODAY - With the rising prevalence of superbugs, researchers are turning their attention to antibiotic molecules. Study co-authors Y. Peter Di (EOH), Berthony Deslouches (EOH), and Ronald Montelaro (IDM) have engineered a cationic antimicrobial peptide named WLBU2, licensed by Pitt spin-off Peptilogics, that's now in a clinical trial for preventing infections associated with knee and hip replacements.  

MAAETC receives CARES Act funding to help minimize impact of pandemic on those with HIV

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MidAtlantic AIDS Education and Training Center Receives $400,000 in CARES Act Funding to support efforts to ‘prevent or minimize the impact of this pandemic on people with HIV’  

Sundermann chosen among Pittsburgh Business Times' 30 under 30

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Alexander Sundermann (IDM '14, EPI '22) was named to the 2020 Pittsburgh Business Times 30 under 30 list which honors young professionals in the Pittsburgh region who are making a difference in their careers. Alex works with PItt's Microbial Genomics Epidemiology Laboratory, currently making that difference in the fight against COVID-19.   

The History and Future of COVID-19

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COVID-19 is one of three novel coronavirus outbreaks in the past 20 years that originated in animals. How is the current outbreak similar and different from the previous ones? What course will COVID-19 take in Pennsylvania?  IDM's  Amy Hartman  puts the current outbreak in perspective with what we know (and don’t know) about SARS-CoV-2. EPI's  Donald Burke  discusses the epidemiological and environmental factors that will shape the likely ph... 

Herpes virus infects billions of people worldwide. Rinaldo explains why there isn’t a vaccine yet.

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NBC NEWS – IDM's Charles Rinaldo said that many have tried to come up with vaccines that use two or three proteins out of the approximately 75 that make up the virus. Those would be safe, but have not protected well. Another approach has been to use a weakened form of the whole virus. In that attenuated, its replication capacity is weakened but it’s not as safe. These failures “are why this is such a monster.”  

Garcia-Bates assists Medical Reserve Corps with COVID-19 initiatives

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IDM’s Tatiana Garcia-Bates signed up to volunteer through the Allegheny County Health Department for the Medical Reserve Corps (MRC), where she instructed a local nursing center's staff on proper N-95 respirator fit.  

Salunke accepted into Internal Medicine Residency at the University of Connecticut

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Graduating master's student in IDM's community practice track Rajeev Salunke (IDM '20) has been accepted into the internal medicine residency program at the University of Connecticut. Hear directly from Rajeev about his background, his experiences at Pitt Public Health, and his aspirations for the future.   

Chinese biotech reports COVID-19 vaccine protects monkeys from new coronavirus, but Reed is cautious

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SCIENCE - IDM's Douglas Reed, who is developing and testing COVID-19 vaccines in monkey studies, says the number of animals was too small to yield statistically significant results. His team also has a manuscript in preparation that raises concerns about the way the Sinovac team grew the stock of novel coronavirus used to challenge the animals: It may have caused changes that make it less reflective of the ones that infect humans.  

What it’s like for IDM student Emerson Boggs and team to moderate Reddit’s wildly popular coronavirus forum

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VICE MEDIA – Emerson Boggs (IDM PhD candidate) says, “I’m a virologist, so I probably spend more time than average looking at outbreaks. I started off as a fervent commenter, and then I wanted the ability to intervene because the science stuff got bad pretty quickly.” The subreddit is also rapidly outpacing traditional outbreak reporting. The ability to communicate back and forth easily has helped a lot of people.  

Reed works with lab animals to help defeat the new coronavirus

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SCIENCE – Dozens of research teams are racing to develop animal models that can help find effective COVID-19 vaccines and treatments. IDM’s Douglas Reed is staging experiments in air chambers that attempt to infect monkeys through this route, which both might increase pathogenicity and offer clues about transmission risks. He explains, “We’re trying to get enough virus into them to get some kind of disease.”  

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Recent IDM Publications

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Rubio publishes thesis in Antimicrobial Agents and Therapy 

Rubio publishes thesis in Antimicrobial Agents and Therapy

Abigail Rubio (IDM '20) recently published In vitro Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-emergent Resistance to Ceftolozane-tazobactam, comparing the in vitro susceptibility of multidrug-resistant Pseudomonas aeruginosa isolates 34 collected before and af... (04/20/2021)

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil 

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists... (03/19/2021)

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts 

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha Louise Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O’Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthe... (11/17/2020)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function 

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

Colleen R. Zaccard, Lauren Shapiro, Maria D. Martin-de-Saavedra, Christopher Pratt, Kristoffer Myczek, Amy Song, Marc P. Forrest, Peter Penzes Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately resolved by diffraction-limited light microscopy, which has limit... (11/17/2020)
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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

IDM Videos

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Amanpour & Salk: Vaccine lessons from history (video) 

Amanpour & Salk: Vaccine lessons from history (video)

CNN — Christiane Amanpour discusses with IDM's Peter Salk the 97% drop in polio prevalence within a few years of initial vaccine adoption. In 1953, Dr. Peter Salk was one of the first to receive a polio vaccine—from none other than his father, Jonas Salk. They go on to discuss herd immunity and vac... (01/13/2021)
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"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19 

"It's going to be a long road" - What IDM's Peter Salk thinks about COVID-19

USA TODAY - Jonas Salk’s vaccine helped wipe polio from most of the world, something that many people hope will happen with the coronavirus vaccine. However, IDM's Dr. Peter Salk warns eradicating polio from the U.S. was a long and difficult journey, and he doesn’t expect eliminating COVID-19 will ... (12/29/2020)
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Biden coronavirus task force appointee Michael Osterholm discusses "The COVID Pandemic: The Evolving Reality" (video) 

Biden coronavirus task force appointee Michael Osterholm discusses "The COVID Pandemic: The Evolving Reality" (video)

In a special IDM Seminar, Michael T. Osterholm answers questions regarding the epidemiology of SARS-CoV-2 infection, public health strategies to reduce transmission, and thoughts on how the world will likely look one year from now. Osterholm was recently appointed to President-elect Biden's coronav... (12/17/2020)

Q&A: Peter Salk on the Lessons Learned from Vaccine Development History 

Q&A: Peter Salk on the Lessons Learned from Vaccine Development History

Peter Salk was 11 years old when a University of Pittsburgh team led by his father, the late Jonas Salk, created the inactivated poliovirus vaccine. The day of the 1955 announcement that the vaccine was safe, effective and potent, “everything just went crazy,” he recalls. “There were so many calls ... (11/17/2020)
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HIV-related stigma in healthcare settings during COVID-19 

HIV-related stigma in healthcare settings during COVID-19

As part of the Conversations about COVID-19 seminar series, Mackey Friedman of IDM and BCHS joins IDM's Sarah Krier to discuss how the COVID-19 pandemic is affecting the lives of people living with HIV including their beliefs and attitudes about their healthcare needs and experiences. (10/16/2020)
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