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IDM's Peter Salk on importance of Julius Youngner, polio vaccine pioneer, dead at 96

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NEW YORK TIMES - “I think it’s absolutely fair to say that had it not been for Dr. Youngner, the polio vaccine would not have come into existence,” PETER SALK president of the Jonas Salk Legacy Foundation and a visiting professor at the University of Pittsburgh Graduate School of Public Health, said in an e-mail. He added, “The really important thing to recognize is that the development of the polio vaccine at the University of Pittsburgh was a t... 

Marques offers insignt as Zika season approaches

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TRIB LIVE - In the U.S., there have been 5,264 Zika cases reported, with the vast majority in travelers returning from affected areas in other countries, says ERNESTO MARQUES, associate professor with Pitt Public Health and scientific director of CURA ZIKA, an international alliance with counterparts in Brazil to help fundraising for research into the virus. Learn more about Cura Zika at www.publichealth.pitt.edu/curazika. 

Marques looks for clues to Zika damage in twins

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NEW YORK TIMES - Determining why one twin becomes infected in the womb while the other does not may illuminate how Zika crosses the placenta, how it enters the brain, and whether any genetic mutations make a fetus more resistant or susceptible to Zika infection. Perhaps the virus entered through a weak spot in one placenta’s membrane, said ERNESTO MARQUES, an infectious disease expert at Pitt Public Health and the Oswaldo Cruz Foundation in Recif... 

Study by IDM's Mellors provides new understanding of HIV infections

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A new study represents an important advance toward better treatments and even a cure. “The immune system stays activated, angry, upset and inflamed despite current treatments, and that’s not good,” said study leader JOHN MELLORS of infectious diseases and microbiology. The research, involving various research centers including the National Institute of Allergy and Infectious Diseases, counters the idea “that inflammation and immune-cell activati... 

DC alumni reception brings together friends and colleagues

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Dozens of Pitt Public Health grads from the capital area gathered at Penn Social during the 2017 ASPPH annual meeting, joining Dean Burke and host faculty for hearty conversations and refreshments. If the forecast of snow scared you away, we missed you! Access our photo albums anytime at www.publichealth.pitt.edu/flickr. 

IDM's Ernesto Marques knows Brazil's Zika families suffer a life of struggle and scares

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NEW YORK TIMES - In the impoverished northeast, devoted parents live around the needs of children whose grave disabilities are only beginning to be understood. “These babies, most of them or all of them, they’re going to live very long lives, you can keep them alive a long time, and they will need assistance from someone 24 hours a day,” said ERNESTO MARQUES, an infectious disease expert at the University of Pittsburgh and the Oswaldo Cruz Founda... 

IDM's Mellors finds latent HIV may exist in both resting and non-resting CD4 T cells

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INFECTIOUS DISEASE ADVISOR - Work of study co-author and IDM professor JOHN MELLORS reported that different clonal virus populations can be recovered from the two cell types. The findings suggest that inducible virus production may be a good marker of the latent infectious reservoir in both cell types. Identifying the sources of latent HIV and developing tools to measure improvements in therapies are essential for clinicians and their patients. 

Salk's son: Eradication of polio would make Pittsburgh proud

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TRIBLIVE - “The eradication of polio has been tantalizingly close for years now,” said Dean DONALD BURKE.... IDM visiting professor PETER SALK adds, “When polio is ultimately eradicated, it will be something the University of Pittsburgh and Pittsburghers in general can be proud of. The University played a major role in something that will be earthshaking.” Before that milestone is achieved, Jonas Salk's injectable form of the vaccine must be ... 

Ernesto Marques on how the response to Zika failed millions

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NEW YORK TIMES - Infectious disease specialist with IDM and at the Oswaldo Cruz Foundation in Brazil, ERNESTO MARQUES JR. said Brazilian scientists felt let down when they looked for outside help—at first from European donors and health agencies. “The local researchers’ role was mainly to collect samples,” Marques said bitterly.  

The Opioid Epidemic and a Long Overdue Response

Associate Professor Linda Frank takes thoughtful look at responses to opioid epidemic. From our department and Pitt Public Health there can be many actions that can be taken. 

Microcephaly Found in Babies of Zika-Infected Mothers Months After Birth

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NEW YORK TIMES - Dr. Ernesto T. A. Marques Jr., an infectious disease specialist at the University of Pittsburgh and the Oswaldo Cruz Foundation in Recife, who was not involved in either study, said it could be that because of the initial fetal brain damage, “the necessary pathways and hormones that organize growth of the neonatal brain are not there anymore and the brain doesn’t grow.” 

Pitt Public Health-led study finds HIV-positive men at higher risk of developing heart disease indicator

Men with HIV were at significantly higher risk for development of coronary artery calcium (CAC), an early sign of coronary heart disease, according to a large national study led by the University of Pittsburgh Graduate School of Public Health. In addition, the study identified two modifiable risk factors independently associated with increased incidence of CAC: smoking and increased insulin resistance. The results are published in the journal  A... 

Lawrence A. Kingsley: HIV-positive men at higher risk of developing heart disease indicator

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Men with HIV were at significantly higher risk for development of coronary artery calcium (CAC), an early sign of coronary heart disease, according to a large national study led by the  University of Pittsburgh Graduate School of Public Health . In addition, the study identified two modifiable risk factors independently associated with increased incidence of CAC: smoking and increased insulin resistance. “Taken together, these findings underscor... 

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Recent IDM Publications

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Rubio publishes thesis in Antimicrobial Agents and Therapy 

Rubio publishes thesis in Antimicrobial Agents and Therapy

Abigail Rubio (IDM '20) recently published In vitro Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-emergent Resistance to Ceftolozane-tazobactam, comparing the in vitro susceptibility of multidrug-resistant Pseudomonas aeruginosa isolates 34 collected before and af... (04/20/2021)

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil 

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists... (03/19/2021)

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts 

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha Louise Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O’Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthe... (11/17/2020)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function 

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

Colleen R. Zaccard, Lauren Shapiro, Maria D. Martin-de-Saavedra, Christopher Pratt, Kristoffer Myczek, Amy Song, Marc P. Forrest, Peter Penzes Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately resolved by diffraction-limited light microscopy, which has limit... (11/17/2020)
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Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
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Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)