IDM Faculty News

The History and Future of COVID-19

image
COVID-19 is one of three novel coronavirus outbreaks in the past 20 years that originated in animals. How is the current outbreak similar and different from the previous ones? What course will COVID-19 take in Pennsylvania?  IDM's  Amy Hartman  puts the current outbreak in perspective with what we know (and don’t know) about SARS-CoV-2. EPI's  Donald Burke  discusses the epidemiological and environmental factors that will shape the likely ph... 

Herpes virus infects billions of people worldwide. Rinaldo explains why there isn’t a vaccine yet.

image
NBC NEWS – IDM's Charles Rinaldo said that many have tried to come up with vaccines that use two or three proteins out of the approximately 75 that make up the virus. Those would be safe, but have not protected well. Another approach has been to use a weakened form of the whole virus. In that attenuated, its replication capacity is weakened but it’s not as safe. These failures “are why this is such a monster.”  

Chinese biotech reports COVID-19 vaccine protects monkeys from new coronavirus, but Reed is cautious

image
SCIENCE - IDM's Douglas Reed, who is developing and testing COVID-19 vaccines in monkey studies, says the number of animals was too small to yield statistically significant results. His team also has a manuscript in preparation that raises concerns about the way the Sinovac team grew the stock of novel coronavirus used to challenge the animals: It may have caused changes that make it less reflective of the ones that infect humans.  

Reed works with lab animals to help defeat the new coronavirus

image
SCIENCE – Dozens of research teams are racing to develop animal models that can help find effective COVID-19 vaccines and treatments. IDM’s Douglas Reed is staging experiments in air chambers that attempt to infect monkeys through this route, which both might increase pathogenicity and offer clues about transmission risks. He explains, “We’re trying to get enough virus into them to get some kind of disease.”  

Mellors says natural remedies haven’t been shown to help you fight the coronavirus

image
DISCOVER - As COVID-19 blasts across the globe, viral wellness videos and posts are springing up in its wake. But so far, says John Mellors, IDM professor and chief of infectious diseases at Pitt, no randomized clinical trials have shown vitamins or natural remedies to be effective in treating or preventing COVID-19.  He adds, if you're already eating a balanced diet, suppliments probably aren’t going to juice your COVID-19 immunity.  

Rinaldo helps with coronavirus test development and launch

image
UPMC – A new test for COVID-19 was created by a virology team including Charles Rinaldo, chair and professor of infectious diseases and microbiology and director of the UPMC Clinical Virology Laboratory. The health system plans to increase lab capacity and open testing sites around the state. The test follows U.S. CDC guidelines and was validated under the Clinical Laboratory Improvement Amendments program of the Centers for Medicare & Medicaid ... 

Did a woman get coronavirus twice? Burke is skeptical.

image
WIRED - News reports detailing the case raised the possibility that people may not be developing immunity to the new coronavirus, even after they’ve recovered. But Donald Burke, dean emeritus and international infectious disease specialist, says there’s not enough data to support that conclusion. “The question is really: How good is the proof? And we’re a long way away from anything solid. What we need is the sequence of the virus.”  

Hartman & Mertz serve on global coronavirus panel

image
TRIB LIVE –  Experts from multiple disciplines gather to discuss the outbreak of novel coronavirus COVID-19. Panelists include IDM’s Amy Hartman, who studies emerging viruses and diseases transmitted from animals to people and then among people; and ACHD medical epidemiologist Kristen Mertz, who also serves as an adjunct assistant professor at Pitt Public Health. “Information is coming out very quickly and it’s hard to … know the facts,” Hartman... 

Rinaldo remembers unsung heroes: Pittsburgh men, decades-long study impact HIV/AIDS research

image
U.S. NEWS & WORLD REPORT - For more than three decades, Pitt Men’s Study leaders have gathered with Pittsburgh men and women to remember those who have died and give thanks for the 1,743 men who have participated in the nation’s longest-running HIV/AIDS research project. IDM's Charles Rinaldo has led the effort since the virus surfaced here in 1981. “We are still searching for a true vaccine to prevent HIV,” Rinaldo says. “But we are dedicated t... 

Frank on PrEP: A drug proven to prevent HIV is still slow to catch on

image
TRIB LIVE - Physicians also need to be included in education around prescribing and using PrEP, said IDM's Linda Frank. That goes beyond making sure their patients take a pill a day. It includes working with communities to make sure people have the support and counseling to make healthy decisions. She said, “It’s important to have treatments and vaccines, but we still have to work on that other side of the equation: How do you get people to chan... 

IDM Research Day expanded with guest speakers and more than 70 student presenters

image
The Department of Infectious Diseases and Microbiology held their biggest-ever research day celebration, featuring three guest speakers: Jonathan Oliver spoke about the emerging tick-borne diseases of the northern United States, Daniel Voth talked about using human-derived systems to investigate bacterial pulmonary infection, and David Lampe lectured on inhibiting the spread of malaria by altering the mosquito microbiome.    

MidAtlantic AIDS Education & Training Center receives $14.2 million to extend efforts into 2024

image
INSIDE UPMC - Public health alumnae & RPCVs Marilyn Blasingame (IDM '16) and Ingrid Godfrey (IDM '18), and IDM professor Linda Rose Frank discuss their work on the prevention and treatment  of HIV/AIDS and its co-morbidities through the MidAtlantic AIDS Education & Training Center (MAAETC), which recently was awarded $14.2 million from the Department of Health and Human Services to continue the center’s work for the next five years  

Zika and travel: Marques tells you what you need to know

image
THE NEW YORK TIMES - The virus has been out of the headlines, but that doesn't mean it is gone. The World Health Organization just updated guideines for travelling to the Zika zone. "Summer in the north is winter in the south and vice versa, so you have to consider that," said IDM's Ernesto Marques. The virus is still circulating, but it's less prevalent in colder months than in the summer.   

The Zika virus is still a threat. Here's what Marques, other experts know

image
THE NEW YORK TIMES - Remember Zika? With measles and Ebola grabbing headlines, it is easy to forget the health panic of 2016, when Zika was linked to severe birth defects in thousands of Brazilian newborns whose mothers were infected while pregnant, striking fear across the country and much of the Americas. "The next outbreak is not a matter of if, but when," said IDM's Ernesto Marques.   

Page 4 of 9First   Previous   1  2  3  [4]  5  6  7  8  9  Next   Last   

Search for an Article

Share Your News

Share stories about Pitt Public Health students, researchers, faculty, or staff using the form at publichealth.pitt.edu/sharenews.

Or, forward information to phcomm@pitt.edu.

Recent IDM Publications

image

Rubio publishes thesis in Antimicrobial Agents and Therapy 

Rubio publishes thesis in Antimicrobial Agents and Therapy

Abigail Rubio (IDM '20) recently published In vitro Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-emergent Resistance to Ceftolozane-tazobactam, comparing the in vitro susceptibility of multidrug-resistant Pseudomonas aeruginosa isolates 34 collected before and af... (04/20/2021)

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil 

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

Multiple authors on behalf of the Microcephaly Epidemic Research Group, including IDM's Ernesto Marques, found the frequency of microcephaly in their results is consistent with previous studies. In addition, as children were evaluated at a later age and repeatedly by different groups of specialists... (03/19/2021)

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts 

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha Louise Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O’Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthe... (11/17/2020)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function 

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

Colleen R. Zaccard, Lauren Shapiro, Maria D. Martin-de-Saavedra, Christopher Pratt, Kristoffer Myczek, Amy Song, Marc P. Forrest, Peter Penzes Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately resolved by diffraction-limited light microscopy, which has limit... (11/17/2020)
image

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States 

Prevalence and correlates of prep awareness and use among black men who have sex with men and women (MSMW) in the United States

AIDS AND BEHAVIOR - Friedman, MR, Sang, JM, Bukowski, LA, Chandler, CJ, Egan, JE, Eaton, LA, Matthews, DD, Ho, K, Raymond, HF, & Stall, R. found that PrEP awareness campaigns tailored for black men who have sex with men and women (MSMW), concomitant with STI-to-PrEP interventions, will facilitate g... (10/14/2019)
image

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions 

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

JOURNAL OF VIROLOGY - Using samples from participants in the Multicenter AIDS Cohort study, Garcia-Bates, Palma, Shen, Gambotto, Macatangay, Ferris, Rinaldo, and Mailliard showed that PD-1 activation plays a positive role in initiating the primary T cell response. But later blocking of that pathway... (12/13/2018)

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)