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Marques looks for clues to Zika damage in twins

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NEW YORK TIMES - Determining why one twin becomes infected in the womb while the other does not may illuminate how Zika crosses the placenta, how it enters the brain, and whether any genetic mutations make a fetus more resistant or susceptible to Zika infection. Perhaps the virus entered through a weak spot in one placenta’s membrane, said ERNESTO MARQUES, an infectious disease expert at Pitt Public Health and the Oswaldo Cruz Foundation in Recif... 

Study by IDM's Mellors provides new understanding of HIV infections

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A new study represents an important advance toward better treatments and even a cure. “The immune system stays activated, angry, upset and inflamed despite current treatments, and that’s not good,” said study leader JOHN MELLORS of infectious diseases and microbiology. The research, involving various research centers including the National Institute of Allergy and Infectious Diseases, counters the idea “that inflammation and immune-cell activati... 

DC alumni reception brings together friends and colleagues

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Dozens of Pitt Public Health grads from the capital area gathered at Penn Social during the 2017 ASPPH annual meeting, joining Dean Burke and host faculty for hearty conversations and refreshments. If the forecast of snow scared you away, we missed you! Access our photo albums anytime at www.publichealth.pitt.edu/flickr. 

IDM's Ernesto Marques knows Brazil's Zika families suffer a life of struggle and scares

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NEW YORK TIMES - In the impoverished northeast, devoted parents live around the needs of children whose grave disabilities are only beginning to be understood. “These babies, most of them or all of them, they’re going to live very long lives, you can keep them alive a long time, and they will need assistance from someone 24 hours a day,” said ERNESTO MARQUES, an infectious disease expert at the University of Pittsburgh and the Oswaldo Cruz Founda... 

IDM's Mellors finds latent HIV may exist in both resting and non-resting CD4 T cells

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INFECTIOUS DISEASE ADVISOR - Work of study co-author and IDM professor JOHN MELLORS reported that different clonal virus populations can be recovered from the two cell types. The findings suggest that inducible virus production may be a good marker of the latent infectious reservoir in both cell types. Identifying the sources of latent HIV and developing tools to measure improvements in therapies are essential for clinicians and their patients. 

Salk's son: Eradication of polio would make Pittsburgh proud

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TRIBLIVE - “The eradication of polio has been tantalizingly close for years now,” said Dean DONALD BURKE.... IDM visiting professor PETER SALK adds, “When polio is ultimately eradicated, it will be something the University of Pittsburgh and Pittsburghers in general can be proud of. The University played a major role in something that will be earthshaking.” Before that milestone is achieved, Jonas Salk's injectable form of the vaccine must be ... 

Ernesto Marques on how the response to Zika failed millions

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NEW YORK TIMES - Infectious disease specialist with IDM and at the Oswaldo Cruz Foundation in Brazil, ERNESTO MARQUES JR. said Brazilian scientists felt let down when they looked for outside help—at first from European donors and health agencies. “The local researchers’ role was mainly to collect samples,” Marques said bitterly.  

The Opioid Epidemic and a Long Overdue Response

Associate Professor Linda Frank takes thoughtful look at responses to opioid epidemic. From our department and Pitt Public Health there can be many actions that can be taken. 

Microcephaly Found in Babies of Zika-Infected Mothers Months After Birth

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NEW YORK TIMES - Dr. Ernesto T. A. Marques Jr., an infectious disease specialist at the University of Pittsburgh and the Oswaldo Cruz Foundation in Recife, who was not involved in either study, said it could be that because of the initial fetal brain damage, “the necessary pathways and hormones that organize growth of the neonatal brain are not there anymore and the brain doesn’t grow.” 

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Recent IDM Publications

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells 

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells

NATURE MEDICINE - Gupta, Sanyal, Ratner, Ding, Zerbato, Giacobbi, Venkatachari, Patterson, Chargin, Chen, Mailliard, Rinaldo, and Sluis-Cremer found that the size of the inducible latent HIV-1 reservoir in aviremic subjects on ART is approximately 70-fold larger than previous estimates.  (02/08/2018)

Peripheral blood biomarkers of disease outcome in a monkey model of rift valley fever encephalitis.  

Peripheral blood biomarkers of disease outcome in a monkey model of rift valley fever encephalitis.

JOURNAL OF VIROLOGY - Wonderlich, Caroline, McMillen, Walters, Reed, Barratt-Boyes, and Hartman conclude that African green monkeys are a novel and suitable model for studying the neuropathogenesis of Rift Valley Fever (RVF) and for testing vaccines and therapeutics against this important emerging ... (02/05/2018)
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