IDM Events

IDM Departmental Calendar

Event
Wed 7/15/2020 12:00PM - 1:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Accessing Pre-Exposure Prophylaxis (PrEP): Billing and Coding MidAtlantic AIDS Education and Training Center Webinar/Online Event
Accessing Pre-Exposure Prophylaxis (PrEP): Billing and Coding
Wed 7/15/2020 12:00PM - 1:00PM
** Online/Virtual Event **

The purpose of this webinar is to describe the process of coding for PrEP in WV and PA, discuss the implementation of billing for PrEP, and compare the different options for paying for PrEP.


** Online/Virtual Event **
Mon 7/20/2020 11:00AM - 12:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Virtual HIV in West Virginia: Tackle the Epidemic, Not the Opioids MidAtlantic AIDS Education and Training Center Webinar/Online Event
Virtual HIV in West Virginia: Tackle the Epidemic, Not the Opioids
Mon 7/20/2020 11:00AM - 12:00PM
** Online/Virtual Event **

This webinar will focus on the question of why there is a raging epidemic of addiction. The current opioid epidemic is a symptom of the fraying of the socio-economic fabric of rural United States. We will also look at the reasons why funding should be targeted to substance misuse, not to the drug of the moment.


** Online/Virtual Event **
Tue 7/21/2020 9:00AM - 10:00AM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Special Populations in Ending the HIV Epidemic: Routine HIV Testing in Adolescents MidAtlantic AIDS Education and Training Center Webinar/Online Event
Special Populations in Ending the HIV Epidemic: Routine HIV Testing in Adolescents
Tue 7/21/2020 9:00AM - 10:00AM
** Online/Virtual Event **

At the end of the webinar, participants will be able to describe current guidelines and epidemiology for HIV testing among adolescents, identify key steps in educating health professionals on routine HIV testing for adolescents, and discuss lessons learned and how to implement these lessons learned across EHE regions.


** Online/Virtual Event **
Thu 7/23/2020 2:00PM - 3:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Telehealth and Pre-Exposure Prophylaxis (PrEP) during COVID-19 MidAtlantic AIDS Education and Training Center Webinar/Online Event
Telehealth and Pre-Exposure Prophylaxis (PrEP) during COVID-19
Thu 7/23/2020 2:00PM - 3:00PM
** Online/Virtual Event **

This session will describe PrEP and the importance of adherence during the COVID-19 pandemic, barriers to PrEP that have been brought on by COVID-19, strategies to overcome barriers and promote adherence, and how telehealth can be used to promote PrEP.


** Online/Virtual Event **
Thu 7/30/2020 2:00PM - 3:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Roadmap for COVID-19 Vaccine Development MidAtlantic AIDS Education and Training Center Webinar/Online Event
Roadmap for COVID-19 Vaccine Development
Thu 7/30/2020 2:00PM - 3:00PM
** Online/Virtual Event **

This webinar will describe the process of vaccine development during COVID-19 and discuss the challenges and opportunities associated with vaccine development.


** Online/Virtual Event **

Recent Events

IDM Master's Defense

Renjian Xiao - MS '18: Neuroprotective microRNAs combat HIV associated neurocognitive disorder...

Tuesday 4/24 2:30PM - 4:00PM
Public Health Lecture Hall (A115)

Neuroprotective microRNAs combat HIV associated neurocognitive disorder (HAND) pathogenesis

Abstract: HIV associated neurocognitive disorder (HAND) is one of the most severe HIV co-morbidities. During early stage of HIV-1 infection, virus crosses the blood - brain barrier (BBB) and enter central nervous system (CNS) through infiltrating periphery monocytes/macrophages. These infiltrating infected monocytes/macrophages then serve as the source of virus initiate secondary infection in resident monocytic cells and glial cells. During the establishment of infection, neurons are not directly infected by the virus. However, tremendous volume of pro-inflammatory cytokines and chemokines as well as viral particles are released by infected/ exposed immune and glial cells in local environment leading to the neuronal stress and apoptosis. Clinically, the severity of HAND can be divided into three stages: asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND), and HIV associated dementia (HAD). The successful coverage of highly active anti-retroviral therapies (HAART) have significantly lower the incidence of HAD and MND. However, the ANI remains as the most common co-morbidity of HIV-1 infection. Nearly more than half of individuals living with HIV-1 infection present with some degree of neuronal impairment. Currently, no treatment is available to prevent or treat HAND or ANI. Thus, devising a method to manage HAND helps to improve the quality of life in HIV-1 positive population, which is of great public health significance.

In this study, specific MicroRNAs (miRNAs) have are evaluated to control HAND pathogenesis. MicroRNAs are small non-coding RNAs which play an important role in all biological pathways including homeostasis of cellular interaction, cell proliferation and differentiation, and in CNS, regulate production of neurotoxic and neuroprotective factors. Previous studies in our laboratory have identify specific miRNAs that may have a neuro-protective role. This was based on the studies comparing miRNA profiles between HIV-1 seronegative and HIV-1 seropositive individuals with or without HAND. As a result, my project focus on understanding the ability of these candidate miRNAs to alter neuroinflammatory chemokines/cytokines production as well as HIV production in monocytes/macrophages. In order to test this hypothesis, miRNAs are transduced and expressed in monocytic cell line, THP-1, microglia and finally in primary monocytes derived macrophages (MDMs). Upon LPS stimulation, miR-20a and miR-106b miRNA transduced monocytes cell lines are able to significantly reduce TNF-α production while miR-let-7a significantly downregulates IL6 secretion, similar results were also observed in the presence of NL-YU2 infection. Microglia cell expressing miR-106b was found to inhibit both IL-6 and IL-8 secretion upon LPS stimulation and miR-20a was found to reduce IL-6 production upon TNF-α stimulation. Finally, miR-20a, miR-106b, miR-124 and let-7a were found to reduce HIV-1 viral reactivation in latent HIV-1 cell line, J-Lat, clone full length 10.6. These results indicate that neuroprotective miRNAs may have a role in reducing specific cytokines production and may affect the production of pro-inflammatory factors that resulting in viral reactivation. Thus, these miRNAs could have a potential therapeutics role to minimize neuroinflammatory cytokine induced neuronal death and thus manage HAND progression.

Advisor: Dr. Velpandi Ayyavoo

Last Updated On Monday, April 23, 2018 by Abby Kincaid
Created On Monday, April 23, 2018

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