IDM Events

IDM Departmental Calendar

Event
Wed 7/8/2020 12:00PM - 1:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Importance of Pre-Exposure Prophylaxis (PrEP) in Primary Care: Urban Clinic's Perspective MidAtlantic AIDS Education and Training Center Webinar/Online Event
Importance of Pre-Exposure Prophylaxis (PrEP) in Primary Care: Urban Clinic's Perspective
Wed 7/8/2020 12:00PM - 1:00PM
** Online/Virtual Event **

The purpose of this webinar is to define Pre-exposure Prophylaxis (PrEP), discuss the importance of implementing PrEP in an urban primary care setting, describe the process of prescribing PrEP, and discuss strategies for leveraging resources in an urban area.


** Online/Virtual Event **
Wed 7/15/2020 12:00PM - 1:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Accessing Pre-Exposure Prophylaxis (PrEP): Billing and Coding MidAtlantic AIDS Education and Training Center Webinar/Online Event
Accessing Pre-Exposure Prophylaxis (PrEP): Billing and Coding
Wed 7/15/2020 12:00PM - 1:00PM
** Online/Virtual Event **

The purpose of this webinar is to describe the process of coding for PrEP in WV and PA, discuss the implementation of billing for PrEP, and compare the different options for paying for PrEP.


** Online/Virtual Event **
Mon 7/20/2020 11:00AM - 12:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Virtual HIV in West Virginia: Tackle the Epidemic, Not the Opioids MidAtlantic AIDS Education and Training Center Webinar/Online Event
Virtual HIV in West Virginia: Tackle the Epidemic, Not the Opioids
Mon 7/20/2020 11:00AM - 12:00PM
** Online/Virtual Event **

This webinar will focus on the question of why there is a raging epidemic of addiction. The current opioid epidemic is a symptom of the fraying of the socio-economic fabric of rural United States. We will also look at the reasons why funding should be targeted to substance misuse, not to the drug of the moment.


** Online/Virtual Event **
Tue 7/21/2020 9:00AM - 10:00AM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Special Populations in Ending the HIV Epidemic: Routine HIV Testing in Adolescents MidAtlantic AIDS Education and Training Center Webinar/Online Event
Special Populations in Ending the HIV Epidemic: Routine HIV Testing in Adolescents
Tue 7/21/2020 9:00AM - 10:00AM
** Online/Virtual Event **

At the end of the webinar, participants will be able to describe current guidelines and epidemiology for HIV testing among adolescents, identify key steps in educating health professionals on routine HIV testing for adolescents, and discuss lessons learned and how to implement these lessons learned across EHE regions.


** Online/Virtual Event **
Thu 7/23/2020 2:00PM - 3:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Telehealth and Pre-Exposure Prophylaxis (PrEP) during COVID-19 MidAtlantic AIDS Education and Training Center Webinar/Online Event
Telehealth and Pre-Exposure Prophylaxis (PrEP) during COVID-19
Thu 7/23/2020 2:00PM - 3:00PM
** Online/Virtual Event **

This session will describe PrEP and the importance of adherence during the COVID-19 pandemic, barriers to PrEP that have been brought on by COVID-19, strategies to overcome barriers and promote adherence, and how telehealth can be used to promote PrEP.


** Online/Virtual Event **
Thu 7/30/2020 2:00PM - 3:00PM
MidAtlantic AIDS Education and Training Center Webinar/Online Event
Roadmap for COVID-19 Vaccine Development MidAtlantic AIDS Education and Training Center Webinar/Online Event
Roadmap for COVID-19 Vaccine Development
Thu 7/30/2020 2:00PM - 3:00PM
** Online/Virtual Event **

This webinar will describe the process of vaccine development during COVID-19 and discuss the challenges and opportunities associated with vaccine development.


** Online/Virtual Event **

Recent Events

IDM Dissertation Defense

Parichat Duangkhae - PhD '18: Defining Dengue Virus Infection in Human Skin

Tuesday 4/3 2:00PM - 4:00PM
Public Health Lecture Hall (A115)

DEFINING DENGUE VIRUS INFECTION IN HUMAN SKIN

Abstract: The skin is the primary site of dengue virus (DENV) replication following the bite of an infected mosquito, but the factors that contribute to productive infection in human skin and virus spread out of skin are not understood. We defined the dynamics of DENV infection in human skin explants using quantitative in situ imaging. A transient IFN-α response occurred prior to the productive DENV infection, which initially established in cells in the epidermis. DENV infected a wide variety of cell types including Langerhans cells (LC), dermal macrophages (Mϕ), dermal dendritic cells (DC), fibroblasts, mast cells, and lymphatic endothelium, but keratinocytes were the earliest and quantitatively most important target of DENV infection, contributing to 60% of overall infected skin cell over time. DENV infection led to the recruitment and infection of LC, dermal DC, and dermal Mϕ. These immune cells emigrated out of the skin in increased number as a result of infection, presumably leading to dissemination of virus. Infection of keratinocytes led to the abundant production of inflammatory mediators, most significantly IL-1β. Blocking keratinocyte-derived IL-1β reduced the infection of LC, dermal DC, and dermal Mϕ by 75-90% and decreased the total number of infected cells in epidermis and dermis by 33% and 65%, respectively. In the first demonstration of antibody-dependent enhancement of DENV infection in human skin, we showed that the presence of heterotypic DENV-immune serum enhanced the recruitment and infection of dermal Mϕ by 50-70%, and increased emigration of myeloid cells out of skin. The Aedes aegypti mosquito salivary gland extract had no impact on dermal Mϕ during DENV infection, with or without immune serum. Blocking FcγRIa and FcγRIIa strongly diminished all the antibody-mediated infection of dermal Mϕ, and decreased the number of cell emigrants, resulting in the reduction of the overall number of infected cells in the dermis by 70%, without notable changes in the epidermis. Ethnic differences in skin immune responses to DENV were observed for the first time in our study. In comparison with Caucasian skin, skin from African Americans was able to maintain the protective level of antiviral IFN-α responses for at least 48 hours. This was observed in association with less DENV replication, a reduced production of IL-1β in the epidermis, less recruitment and infection of LC and dermal Mϕ, and less cell emigration out of the skin. These findings may provide a mechanism for the epidemiologic observation that African ancestry protects against severe dengue. Our findings highlight the importance of skin and the complex interplay between resident and immune skin cell populations in DENV infection and dengue pathogenesis.

Advisor: Simon Barratt-Boyes, PhD

Defense Announcement - Duangkhae.pdf

Last Updated On Friday, March 30, 2018 by Abby Kincaid
Created On Tuesday, March 27, 2018

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