Ying Ding, PhD

Assistant Professor, Biostatistics

Contact

7133 Public Health, 130 DeSoto Street, Pittsburgh, PA 15261
R-znvy: lvatqvat@cvgg.rqh
Primary Phone: 967-179-4952

Personal Statement

My primary research interests include semiparametric methods and inferences, especially for time-to-event data; subgroup analysis such as simultaneous inference and biomarker/subgroup identification. Currently, my collaborative research focuses on proteomic experiment design, network analysis for psychiatric disorders and progression analysis of AMD (Age-related Macular Degeneration).

Education

Ph.D. (2010) Department of Biostatistics, University of Michigan, MI
M.A. (2005) Department of Mathematics, Indiana University Bloomington, IN
B.S. (2003) Department of Mathematics, Nanjing University, China

Teaching

Applied Survival Analysis BIOST2066 Fall 2019
Survival Analysis BIOST2054/STAT2261 Spring 2018, 2019

Applied Mixed Models BIOST2086 Spring 2013, Spring 2014, Spring 2016, 2017
Biostatistics Seminar  BIOST2025 Spring 2014, Fall 2014

Research Funding

  1. Funding Agency: UPMC 
    Grant Title: Competitive Medical Research Fund
    Role on Grant:: Principal Investigator
    Years Inclusive: 7/1/2015 - 12/31/2017
    Total Direct Costs: $25,000                                                                  
  2. Funding Agency: NIH/NIMH
    Grant Number: R03MH108849
    Grant Title: Novel and Robust Methods for Differential Protein Network Analysis of Proteomics Data in Schizophrenia Research
    Role on Grant: Principal Investigator
    Years Inclusive: 7/1/2016 – 6/30/2018
    Total Direct Costs: $100,000
  3. Funding Agency: Clinical and Translational Science Institute, University of Pittsburgh
    Grant Title: Deep Learning with GWAS to Predict AMD Progression
    Role on Grant: Principal Investigator
    Years Inclusive: 1/1/2019 – 12/31/2019
    Total Direct Costs: $10,000

Selected Publications

*: corresponding/senior author; +: co-first author; _: student advisee

 

2019:

  1. Ding Y*, Wei Y, Wang X. Logical Inference on Treatment Efficacy When Subgroups Exist. Book Chapter In: Ting N, Cappelleri JC, Ho S, Chen DG. Design and Analysis of Subgroups with Biopharmaceutical Applications. New York: Springer, 2019. Forthcoming.
  2. Wei Y+, Liu Y+, Sun T, Chen W, Ding Y*. (2019) Gene-based Association Analysis for Bivariate Time-to-event Data through Functional Regression with Copula Models. (The earlier version won the LiDS Conference Student Paper Award.) Biometrics. DOI:10.1111/biom.13165
  3. Sun T, Ding Y*. (2019) Copula-based semiparametric transformation model for bivariate data under general interval censoring. (The earlier version won the ENAR Distinguished Student Paper Award.) Biostatistics. DOI: 10.1093/biostatistics/kxz032
  4. Sun Z, Chen L, Xin H, Huang Q, Cillo AR, Tabib T, Kolls JK, Bruno TC, Lafyatis R, Vignali DAA, Chen K, Ding Y*, Hu M*, Chen W*. (2019) BAMM-SC: A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies. (The earlier version won the ENAR Distinguished Student Paper Award.) Nature Communication. 10(1):1649 Doi: 10.1038/s41467-019-09639-3. PMID: 30967541
  5. Sun T+, Liu Y+, Cook RJ, Chen W, Ding Y*. (2019). Copula-based Score Test for Bivariate Time-to-event Data, with Application to a Genetic Study of AMD Progression. (The earlier version won the Best Poster Award in ASA Pittsburgh Chapter 2017 Meeting.) Lifetime Data Analysis. DOI: 10.1007/s10985-018-09459-5. PMID: 30560439
  6. Lin HM, Xu H, Ding Y, Hsu JC. (2019). Correct and Logical Inference on Efficacy in Subgroups and Their Mixture for Binary Outcomes. Biometrical Journal. 61(2): 8-26. PMID: 30353566

2018:

  1. Ding Y*, Li GY, Liu Y, Ruberg SJ, Hsu JC. (2018). Confident Inference For SNP Effects On Treatment Efficacy. Annals of Applied Statistics. 12(3): 1727-1748.
  2. Ding Y*,+, Kong S+, Kang S, Chen W. (2018). A Semiparametric Imputation Approach for Regression with Censored Covariate, with Application to an AMD Progression Study. Statistics in Medicine. 37: 3293–3308. PMID: 29845616
  3. Yan Q, Ding Y+, Liu Y, Sun T, Fritsche LG, Clemons T, Ratnapriya R, Klein ML, Cook RJ, Liu Y, Fan R, Wei L, Abecasis GR, Swaroop A, Chew EY, AREDS2 research group, Weeks  DE, Chen W. (2018). Genome-wide Analysis of Disease Progression in Age-related Macular Degeneration. Human Molecular Genetics. 27(5):929-940. PMID: 29346644
  4. Sun Z, Wang T, Deng K, Wang X-F, Lafyatis R, Ding Y, Hu M, Chen W. (2018). DIMM-SC: A Dirichlet mixture model for clustering droplet-based single cell transcriptomic data. Bioinformatics. 34(1): 139-146. PMID: 29036318

2017 and before:

  1. Ding Y, Liu Y, Yan Q, Fritsche LG, Cook RJ, Clemons T, Ratnapriya R, Klein ML, Abecasis GR, Swaroop A, Chew EY, Weeks DE, Chen W. (2017). Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores. Genetics. 206(1):119-133. PMID: 28341650 
  2. Wang T, Ren Z, Ding Y, Zhou F, Sun Z, MacDonald ML, Sweet RA, Chen W. (2016). FastGGM: An efficient algorithm for the inference of Gaussian graphical model in biological networks. PLoS Computational Biology. 12(2): e1004755. PMID: 26872036
  3. Fan R, Wang Y, Yan Q, Ding Y, Weeks DE, Lu Z, Ren H, Cook R J, Xiong M, Swaroop A, Chew E Y, and Chen W. (2016). Gene-based Association Analysis for Censored Traits Via Fixed Effect Functional Regressions. Genetic Epidemiology. 40(2): 133-43. PMID: 26782979
  4. Ding Y*, Lin HM, Hsu JC. (2016). Subgroup Mixable Inference on Treatment Efficacy in Mixture Populations, with an Application to Time-to-Event Outcomes. Statistics in Medicine. 35(10):1580-94. PMID: 26646305
  5. Ding Y*, Nan B. (2015). Estimating Mean Survival Time: When is it Possible? Scandinavian Journal of Statistics 42(2):397-413. PMID: 26019387 PMCID: PMC4442028
  6. Shen L, Ding Y, Battioui C. A Framework of Statistical Methods for Identification of Subgroups with Differential Treatment Effects in Randomized Trials. (2015) In: Chen Z, Liu A, Qu Y, Tang L, Ting N & Tsong Y, eds. Applied Statistics in Biomedicine and Clinical Trials Design: Selected Papers from 2013 ICSA/ISBS Joint Statistical Meetings. New York: Springer.
  7. Ding Y*, Fu H. (2013). Bayesian Indirect and Mixed Treatment Comparisons Across Longitudinal Time Points. Statistics in Medicine 32 (15):2613-28. PMID: 23229717
  8. Banerjee M, Ding Y, Noone A. (2012). Identifying Representative Trees from Ensembles. Statistics in Medicine 31(15):1601-16.  PMID: 22302520
  9. Ding Y, Nan B. (2011). A Sieve M-theorem for Bundled Parameters in Semiparametric Models, with Application to the Efficient Estimation in a Linear Model for Censored Data. Annals of Statistics 39(6): 3032-3061. PMID: 24436500  PMCID:  PMC3890689
  10. Ding Y, Choi H, Nesvizhskii AI. (2008). Adaptive Discriminant Function Analysis and Reranking of MS/MS Database Search Results for Improved Peptide Identification in Shotgun Proteomics. Journal of Proteome Research 7(11): 4878-89.  PMID: 18788775  PMCID: PMC3744223

Complete List of Published Work in My Bibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/1f510URSbxjQh/bibliography/47222780/public/?sort=date&direction=ascending

Ying Ding