Xiuxia Zhou, PhD

My research interest has been focused on the role of N-glycosylation/sialylation on the abnormal epithelium repair in vitro and ex vivo in severe asthma. Particularly, human airway epithelial cells (HAECs) in air-liquid interface (ALI) culture are utilized to explore the molecular mechanisms of N-glycosylation associated ST6GAL1-MUC4B-ErbB2 axis in regulating epithelium wound repair through influencing epithelial cell proliferation / differentiation and integrity in chronic Type-2 inflammatory background. In addition, the effects of ST6GAL1-MUC4B-ErbB2 axis on other inflammatory cells are explored, as well as the interactions with Type-2 cytokine IL-13/IL-4R signaling pathways and their potential functions/implications in asthma.

DEGREES

1986 - Lanzhou University / B.S. of Biochemistry

1995 - Hebei Medical University / M.S. of Biochemistry

2000 - Hebei Medical University / Ph.D of Molecular Biology

2001 - National Jewish Medical and Research Center / Post-doc of asthma research

CERTIFICATIONS

2001/Hebei Medical University/Professor

HONORS

1998 - Awarded “Sun Zuomin” prize at Hebei Medical University

1999 - Outstanding Ph. D student at Hebei Medical University

2000 - Awarded “Sun Zuomin” prize at Hebei Medical University

2001 - Awarded Hebei Scientific and Technological Progress – First Prize

1986-2001/ Hebei Medical University, China /Biochemistry

1995-2001/Hebei Medical University, China/ Molecular Biology

Zhou X, Yin G. Experimental studies on effects of excessive iodine intake on morphology and function of kidney in mice. Chinese Journal of Preventative Medicine. 1996 Nov;30 (6):340-2.

Zhou X, Yin G, Qi J, Zhao J. The Effects of Excess Iodine on Brain Development and the Levels of Serum Free Thyroid Hormone. Journal of Hebei Academy of Sciences. 1997;14 (3): 46-48.

Zhou X, Wen J, Han M. The Change of MMP-2 Gene Expression and Collagen Turnover during Vascular Restenosis Development. Chinese Journal of Biochemistry and Molecular Biol. 1999;15 (06): 997-1001.

Zhou X, Wen J, Han M. Effects of IL-1beta and TNF-alpha on MMP-2 and Osteopontin Gene Expression of Rat Vascular Smooth Muscle Cells. Chinese Journal of Atherosclerosis. 1999;7 (4): 292-295.

Zhou X, Wen J, Han M. The Change of Plasma Tissue Plasminogen Activator and Its Inhibitor Activity and Collagen Turnover during Vascular Restenosis Development. Chinese Journal of Atherosclerosis. 2000;8 (2): 96-98.

Han M, Wen J, Li X, Zhou X. Comparison of Gene Expression pattern and Migration at Different Phase of Cell Cycle in Vascular Smooth Muscle Cell Stimulated by Cytokines. Chinese Journal of Biochemistry and Molecular Biol. 2000;16 (06): 809-813.  ISSN: 1007-7626.}

Zhou X, Wen J, Han M.  Effects of Serum from HuoXueHuayu Chinese Medicine on Vascular Smooth Muscle Cell Migration Related Gene Expression. Journal of Hebei Medical University. 2000;21 (4): 217.

Wenzel SE, Trudeau JB, Barnes SM, Zhou X, Cundall MJ, Westcott JY, McCord K, Chu HW. TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts. J Immunol. 2002 Oct 15;169 (8): 4613-9.

Han M, Wen J, Zhou X.  Effect of yiqi huoxue huayu recipe on vascular collagen turnover and relevant gene expression. Chinese Journal of Integrated Traditional Chinese and Western Medicine. 2004 Feb;24 (2):136-9.

Zhou X, Trudeau JB, Schoonover KJ, Lundin JI, Barnes SM, Cundall MJ, Wenzel SE. Interleukin-13 augments transforming growth factor-beta1-Induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts. Am J Physiol Cell Physiol. 2005 Feb;288 (2):C435-42.

Kotaru C, Schoonover KJ, Trudeau JB, Huynh ML, Zhou X, Hu H, Wenzel SE. Regional fibroblast heterogeneity in the lung: implications for remodeling. Am J Respir Crit Care Med. 2006 Jun 1;173 (11):1208-15.

Zhou X, Hu H, Huynh ML, Kotaru C, Balzar S, Trudeau JB, Wenzel SE. Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts. J Allergy Clin Immunol. 2007 Jun;119 (6):1388-97.

Zhou X, Wu W, Hu H, Milosevic J, Konishi K, Kaminski N, Wenzel SE. Genomic differences distinguish the myofibroblast phenotype of distal lung fibroblasts from airway fibroblasts. Am J Respir Cell Mol Biol. 2011 Dec;45 (6):1256-62.

Zhou X, Hu H, Balzar S, Trudeau JB, Wenzel SE. MAPK regulation of IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-beta1 and IL-13 in human airway fibroblasts. J Immunol. 2012 Jun 15;188 (12):6046-54.

Watanabe T, Fajt ML, Trudeau JB, Voraphani N, Hu H, Zhou X, Holguin F, Wenzel SE. Brain-Derived Neurotrophic Factor Expression in Asthma. Association with Severity and Type 2 Inflammatory Processes. Am J Respir Cell Mol Biol. 2015 Dec;53 (6):844-52.

Inoue H, Hattori T, Zhou X, Etling EB, Modena BD, Trudeau JB, Holguin F, Wenzel SE. Dysfunctional ErbB2, an EGF receptor family member, hinders repair of airway epithelial cells from asthmatic patients. J Allergy Clin Immunol. 2019; 143 (6):2075-2085

Zhou X, Kinlough CL, Hughey RP, Jin M, Inoue H, Etling E, Modena BD, Kaminski N, Bleecker ER, Meyers DA, Jarjour NN, Trudeau JB, Holguin F, Ray A, Wenzel SE. Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation. J Clin Invest Insight. 2019 Mar; 4(5)

Li Z, Zeng M, Deng Y, Zhao J, Zhou X, Trudeau JB, Goldschmidt E, Moore JA, Chu H, Zhang W, Yin S, Liu Z, Di YP, Lee SE, Wenzel SE. Nasal polyps 15-lipoxygenase 1 promotes CCL26/Eotaxin3 expression through ERK activation. J Allergy Clin Immunol. 2019 Jul 10.

Camiolo MJ, Zhou X, Wei Q, Trejo Bittar HE, Kaminski N, Ray A, Wenzel S.  Machine learning implicates the IL-18 signaling axis in severe asthma. J Clin Invest Insight. 2021 Nov 8;6(21):e149945.

Jin M, Watkins S, Larriba Y, Wallace C, Croix C, Zhou X, Zhao J, Peddada S, Wenzel SE. J Allergy Clin Immunol. 2022 Feb;149(2):579-588