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Tatiana Garcia-Bates, PhD

Research Assistant Professor, Infectious Diseases and Microbiology

Contact

2119 Public Health, 130 DeSoto Street, Pittsburgh, PA 15261
R-znvy: gtnepvn@cvgg.rqh
Primary Phone: 967-838-2734


Personal Statement

Dr. Garcia-Bates graduated with a bachelor's degree in Medical Technology from Pontificia Universidad Javeriana located in Bogota, Colombia in 2000. She then completed her M.S. and Ph.D. in Immunology and Microbiology from the department of Immunology and Microbiology at the University of Rochester, NY in 2009. Her research training are in the areas of immunology, virology, and cancer. Research interests include the study of immunological responses, both cellular and humoral, against acute and chronic viral infections in order to develop effective vaccines and immunotherapies for infectious diseases and cancer. During her graduate work she discovered the key role of the transcription factor peroxisome proliferator activated receptor gamma (PPARg) on the differentiation and death of normal and malignant B lymphocytes and how PPARg ligands can be used as adjuvants for vaccine therapies. She then translated her knowledge on B cell immunology to infectious diseases, such as the mosquito-borne viral disease dengue fever. During this work, she revealed that during secondary severe dengue infections, there is a massive expansion of virus-specific plasmablasts (antibody-secreting cells) that may serve as an important early biomarker of disease, suggesting a major role for the B cell response in dengue pathogenesis.

Dr. Garcia-Bates broaden her experience in immunology by working as a post-doctoral fellow with a dendritic cell-based vaccine strategy against HPV positive cancers. The strategy utilized adenoviral vectors that were designed to co-express relevant oncoproteins along with an immune checkpoint inhibitory antibody against PD-1 with the purpose of enhancing cytotoxic T cell responses to HPV-positive cancers. 

Dr. Garcia-Bates returned to the Department of Infectious Diseases and Microbiology (IDM) at the Graduate School of Public Health (GSPH) in 2015 and she is currently working on the immunoregulatory effects of a personalized DC-based HIV immunotherapeutic developed in Dr. Rinaldo’s lab. Specifically, the overarching aim is to determine the impact of using checkpoint receptor blockade (such as anti-PD1) strategies on the efficacy of the DC-based therapy against HIV. 


Education

2000 |  Pontificia Universidad Javeriana, Bogota, Colombia  |  BS Medical Technologist

2006 |  University of Rochester, Rochester, NY  |  MS Immunology and Microbiology

2009 | University of Rochester, Rochester, NY  | PhD Immunology and Microbiology











Teaching

IDM 2003, Host Response to Microbial Infection. Lecture: Recognition of Antigen by B cells. 

IDM 3440, Vaccines and Immunity, Lecture: Adjuvants in vaccines. 


Selected Publications

Garcia-Bates TM, Kim E, Concha-Benavente F, Trivedi S, Mailliard RB, Gambotto A, Ferris RL. (2016). Enhanced cytotoxic CD8 T cell priming using dendritic cell-expressing human papillomavirus-16 E6/E7-p16INK4 fusion protein with sequenced anti-programmed death-1. J Immunol, 196(6), 2870-2878. doi:10.4049/jimmunol.1502027

Trivedi S, Srivastava RM, Concha-Benavente F, Garcia-Bates TM, Li J, Ferris RL. (2015). Anti-EGFR targeted monoclonal antibody isotype influences anti-tumor immunity in head and neck cancer patients. J ImmunoTherapy of Cancer, 3(Suppl 2), P316. doi:10.1186/2051-1426-3-S2-P316

Nascimento EJM, Hottz ED, Garcia-Bates TM, Bozza F, Marques ETA, Barratt-Boyes SM. (2014). Emerging concepts in dengue pathogenesis: Interplay between plasmablasts, platelets, and complement in triggering vasculopathy. Crit Rev Immunol, 34(3), 227-240. doi:10.1615/CritRevImmunol.2014010212

Garcia-Bates TM, Cordeiro MT, Nascimento EJM, Smith AP, De Melo KMS, McBurney S P Barratt-Boyes, S. M. (2013). Association between magnitude of the virus-specific plasmablast response and disease severity in dengue patients. J Immunol, 190(1), 80-87. doi:10.4049/jimmunol.1103350

Garcia-Bates TM, Baglole CJ, Bernard MP, Murant TI, Simpson-Haidaris PJ, Phipps RP. (2009). Peroxisome proliferator-activated receptor γ ligands enhance human B cell antibody production and differentiation. J Immunol, 183(11), 6903-6912. doi:10.4049/jimmunol.0900324

Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Sime PJ. (2009). Electrophilic peroxisome proliferator-activated receptor-γ ligands have potent antifibrotic effects in human lung fibroblasts. Amer J Respiratory Cell Molec Biol, 41(6), 722-730. doi:10.1165/rcmb.2009-0006OC

Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Sime PJ. (2009). Peroxisome proliferator-activated receptor-γ ligands induce heme oxygenase-1 in lung fibroblasts by a PPARγ-independent, glutathione-dependent mechanism. Amer J Physiol - Lung Cellular and Molecular Physiology, 297(5). doi:10.1152/ajplung.00148.2009

Sniderhan LF, Garcia-Bates TM, Burgart M, Bernstein SH, Phipps RP, Maggirwar SB. (2009). Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma. Experimtl Hematol, 37(11), 1295-1309. doi:10.1016/j.exphem.2009.08.005

Garcia-Bates TM, Peslak SA, Baglole CJ, Maggirwar SB, Bernstein SH, Phipps RP.  (2009). Peroxisome proliferator-activated receptor gamma overexpression and knockdown: Impact on human B cell lymphoma proliferation and survival. Cancer Immunol Immunother, 58(7), 1071-1083. doi:10.1007/s00262-008-0625-z

O'Brien JJ, Baglole CJ, Garcia-Bates TM, Blumberg N, Francis CW, Phipps RP. (2009). 15-deoxy-Δ12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. J Thrombosis and Haemostasis, 7(1), 182-189. doi:10.1111/j.1538-7836.2008.03191.x

Garcia-Bates TM, Bernstein SH, Phipps RP. (2008). Peroxisome proliferator-activated receptor γ overexpression suppresses growth and induces apoptosis in human multiple myeloma cells. Clin Cancer Res, 14(20), 6414-6425. doi:10.1158/1078-0432.CCR-08-0457

Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP. (2008). Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies. PPAR Res, doi:10.1155/2008/834612

Lehmann GM, Garcia-Bates TM, Smith TJ, Feldon SE, Phipps RP. (2008). Regulation of lymphocyte function by PPARγ: Relevance to thyroid eye disease-related inflammation. PPAR Research. doi:10.1155/2008/895901

Tatiana  Garcia-Bates
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