Associate Professor, Human Genetics
Associate Professor, Department of Neurobiology
Member, Center for Neuroscience (CNUP)
3115 Public Health
Primary Phone: 967-179-2758
Secondary Phone: 967-193-7871
The major focus of the Padiath lab is to understand the molecular mechanisms underlying various neurological disorders. To achieve this, the lab uses human genetic approaches as well as research on model organisms such as mice and flies. Presently, we are studying the genetic basis of the a class of demyelinating disorders know as leukodystrophies.
A mojor focus of lab is the adult onset demyelinating disorder, Autosomal Dominant Leukodystrophy (ADLD) that is caused by the overexpression of the nuclear lamina protein, Lamin B1.
We hope that understanding demyelinating disease mechanisms will help us identify novel pathways that regulate myelin formation and maintenance.
Molecular mechanisms of neurological disorders, especially myelin formation and maintenance, using data on humans and mouse and fruit fly models.
Molecular organization and structure of the nuclear lamina
1995 | Kilpauk Medical College, Madras, Dr. MGR Medical University, Madras, India | Bachelor of Medicine and Surgery (MBBS)
2001 | Indian Institute of Science, Bangalore, India | Doctor of Philosophy (PhD)
Hugen 2040: Molecular Basis of Inherited Disease
HUGEN2034: Biochemical and Molecular Genetics of Complex Diseases
HUGEN2032: Genetic Techniques
MSNBIO 2112: Neurobiology of Disease
MED 5115 Genetics - Human Genetics
MSNBIO 2101 / NROSCI 2101: Cell and Molecular Neurobiology
Details of the Leukodystrophy study conducted by the Padiath lab
Full list of publications: https://www.ncbi.nlm.nih.gov/sites/myncbi/14SZefWFJoeQV/bibliography/47998377/public/?sort=date&direction=descending