Jian-Min Yuan, MD, PhD

Professor, Epidemiology

Arnold Palmer Endowed Chair in Cancer Prevention, UPMC Hillman Cancer Center

Associate Director, Cancer Control and Population Science, UPMC Hillman Cancer Center

Co-Leader, Cancer Epidemiology and Prevention, UPMC Hillman Cancer Center

Contact

University of Pittsburgh Medical Center (Shadyside) Cancer Pavilion, 5150 Centre Avenue - Suite 4C, Room 470, Pittsburgh, PA 15232
R-znvy: lhnaw@hczp.rqh
Primary Phone: 967-319-2334
Fax: 967-319-2383


Personal Statement

Dr. Yuan’s research focuses on the etiologic and protective roles of environmental exposures and genetic factors, and their interaction in the development of cancers. He is Principal Investigator (PI) of both the Shanghai Cohort Study and the Singapore Chinese Health Study ─ two population-based prospective cohort studies of more than 80,000 middle-aged men and women with available biospecimens collected at baseline and under surveillance for more than 25 years. He is also the current PI of the Pittsburgh Lung Screening Study that has collected repeated annual blood samples and biannual low-dose CT scans on a cohort of 3600 smokers at high risk for lung cancer.  The ultimate goal of Dr. Yuan’s research is to discover and validate biomarkers that can characterize individuals at high risk for cancer and early detection of cancer, and to identify natural agents for primary cancer prevention.  Dr. Yuan is passionate about teaching and training on graduate students and post-doctoral fellows. He is the Director of the Translational Research Training in Cancer Etiology and Prevention Program, a multi-disciplinary cross-college training program at University of Pittsburgh Cancer Institute and the Department of Epidemiology, and is PI  of the National Cancer Institute (NCI) funded T32 training grant.


Education

1983 | Shanghai Medical University | MD, Medicine
1986 | Shanghai Medical University | MPH, Public Health/Epidemiology
1996 | University of Southern California | PhD, Epidemiology


Research Interests

  • Environmental exposure and gene-environmental interaction in the etiology of cancer
  • Biomarkers for cancer risk assessment and early detection
  • Chemopreventive effect of dietary agents for primary prevention of cancer 


Research Support

Principal Investigator

06/14/2017-05/31/2022
NIH/NCI
R01CA213123-01
Randomized Clinical Trial of Lung Cancer Chemoprevention with Sulforaphane in Former Smokers


08/05/2014-07/31/2024
NIH/NCI
T32 CA186873
Research Training in Cancer Etiology and Prevention 

 

Co-Principal Investigator/Sub-contract PI/Program Leader

09/10/1997-07/31/2024
NIH/NCI P30CA047904 (Ferris)
Cancer Center Support Grant

 

09/21/2016– 08/30/2021
NIH/NCI
P01CA138338 (Hecht)
Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking (Subcontract PI)

 

09/06/2017– 07/31/2022
NIH/NCI
U01CA213285 (Hanash)
Development of Risk and Early Detection Biomarker for Small Cell Lung Cancer (Subcontract PI)

 

08/01/2017– 03/31/2023
NIH/NCI
U19CA203654 (Amos/Brennan)
Integrative analysis of lung cancer etiology and risk, Project 2: Biomarkers of lung cancer risk (Subcontract PI)

 

Co-Investigator

 

09/01/2016- 08/31/2021
NIH/NCI
U01CA214165 (Herman)
Ultrasensitive Detection of Tumor Specific DNA Methylation Changes for the Early Detection of Lung Cancer

 

07/01/2020-06/30/2025
NIH/NCI
R01CA247220 (Lokshin)
Development of Novel Ovarian Cancer Biomarkers for Early Detection Algorithms

 

12/01/2020-11/30/2025
NIH/NCI
R01CA247220 (Lokshin)
Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer

 

12/01/2020-12/31/2022
PA Department of Health
Contract number 4400018535 (Talbott)
Case-Control Study of Childhood Cancer in Southwestern Pennsylvania

 

09/01/2020-08/31/2023
VINGROUP Innovation Fund, Vietnam
Res Grant (Luu)
Prediction for the Progression of Fatty Liver Disease to Hepatocellular Carcinoma and Other Health Outcomes: A Novel Approach Using Artificial Intelligence Technique
 


Selected Publications

  • Chen C, Lim JT, Chia NC, Wang L, Tysinger B, Zissimopolous J, Chong MZ, Wang Z, Koh GC, Yuan J-M, Tan KB, Chia KS, Cook AR, Malhotra R, Chan A, Ma S, Ng TP, Koh WP, Goldman DP, Yoong J: The long-term impact of functional disability on hospitalization spending in singapore. J Econ Ageing 2019;14. PMC6922027
  • Chen GC, Neelakantan N, Martin-Calvo N, Koh WP, Yuan J-M, Bonaccio M, Iacoviello L, Martinez-Gonzalez MA, Qin LQ, van Dam RM: Adherence to the mediterranean diet and risk of stroke and stroke subtypes. Eur J Epidemiol 2019;34:337-349.
  • Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Borst GJ, Bottinger EP, Broer L, Campbell H, Chanock S, Chee ML, Chen G, Chen YI, Chen Z, Chiu YF, Cocca M, Collins FS, Concas MP, Corley J, Cugliari G, van Dam RM, Damulina A, Daneshpour MS, Day FR, Delgado GE, Dhana K, Doney ASF, Dorr M, Doumatey AP, Dzimiri N, Ebenesersdottir SS, Elliott J, Elliott P, Ewert R, Felix JF, Fischer K, Freedman BI, Girotto G, Goel A, Gogele M, Goodarzi MO, Graff M, Granot-Hershkovitz E, Grodstein F, Guarrera S, Gudbjartsson DF, Guity K, Gunnarsson B, Guo Y, Hagenaars SP, Haiman CA, Halevy A, Harris TB, Hedayati M, van Heel DA, Hirata M, Hofer I, Hsiung CA, Huang J, Hung YJ, Ikram MA, Jagadeesan A, Jousilahti P, Kamatani Y, Kanai M, Kerrison ND, Kessler T, Khaw KT, Khor CC, de Kleijn DPV, Koh WP, Kolcic I, Kraft P, Kramer BK, Kutalik Z, Kuusisto J, Langenberg C, Launer LJ, Lawlor DA, Lee IT, Lee WJ, Lerch MM, Li L, Liu J, Loh M, London SJ, Loomis S, Lu Y, Luan J, Magi R, Manichaikul AW, Manunta P, Masson G, Matoba N, Mei XW, Meisinger C, Meitinger T, Mezzavilla M, Milani L, Millwood IY, Momozawa Y, Moore A, Morange PE, Moreno-Macias H, Mori TA, Morrison AC, Muka T, Murakami Y, Murray AD, de Mutsert R, Mychaleckyj JC, Nalls MA, Nauck M, Neville MJ, Nolte IM, Ong KK, Orozco L, Padmanabhan S, Palsson G, Pankow JS, Pattaro C, Pattie A, Polasek O, Poulter N, Pramstaller PP, Quintana-Murci L, Raikkonen K, Ralhan S, Rao DC, van Rheenen W, Rich SS, Ridker PM, Rietveld CA, Robino A, van Rooij FJA, Ruggiero D, Saba Y, Sabanayagam C, Sabater-Lleal M, Sala CF, Salomaa V, Sandow K, Schmidt H, Scott LJ, Scott WR, Sedaghati-Khayat B, Sennblad B, van Setten J, Sever PJ, Sheu WH, Shi Y, Shrestha S, Shukla SR, Sigurdsson JK, Sikka TT, Singh JR, Smith BH, Stancakova A, Stanton A, Starr JM, Stefansdottir L, Straker L, Sulem P, Sveinbjornsson G, Swertz MA, Taylor AM, Taylor KD, Terzikhan N, Tham YC, Thorleifsson G, Thorsteinsdottir U, Tillander A, Tracy RP, Tusie-Luna T, Tzoulaki I, Vaccargiu S, Vangipurapu J, Veldink JH, Vitart V, Volker U, Vuoksimaa E, Wakil SM, Waldenberger M, Wander GS, Wang YX, Wareham NJ, Wild S, Yajnik CS, Yuan J-M, Zeng L, Zhang L, Zhou J, Amin N, Asselbergs FW, Bakker SJL, Becker DM, Lehne B, Bennett DA, van den Berg LH, Berndt SI, Bharadwaj D, Bielak LF, Bochud M, Boehnke M, Bouchard C, Bradfield JP, Brody JA, Campbell A, Carmi S, Caulfield MJ, Cesarini D, Chambers JC, Chandak GR, Cheng CY, Ciullo M, Cornelis M, Cusi D, Smith GD, Deary IJ, Dorajoo R, van Duijn CM, Ellinghaus D, Erdmann J, Eriksson JG, Evangelou E, Evans MK, Faul JD, Feenstra B, Feitosa M, Foisy S, Franke A, Friedlander Y, Gasparini P, Gieger C, Gonzalez C, Goyette P, Grant SFA, Griffiths LR, Groop L, Gudnason V, Gyllensten U, Hakonarson H, Hamsten A, van der Harst P, Heng CK, Hicks AA, Hochner H, Huikuri H, Hunt SC, Jaddoe VWV, De Jager PL, Johannesson M, Johansson A, Jonas JB, Jukema JW, Junttila J, Kaprio J, Kardia SLR, Karpe F, Kumari M, Laakso M, van der Laan SW, Lahti J, Laudes M, Lea RA, Lieb W, Lumley T, Martin NG, Marz W, Matullo G, McCarthy MI, Medland SE, Merriman TR, Metspalu A, Meyer BF, Mohlke KL, Montgomery GW, Mook-Kanamori D, Munroe PB, North KE, Nyholt DR, O'Connell J R, Ober C, Oldehinkel AJ, Palmas W, Palmer C, Pasterkamp GG, Patin E, Pennell CE, Perusse L, Peyser PA, Pirastu M, Polderman TJC, Porteous DJ, Posthuma D, Psaty BM, Rioux JD, Rivadeneira F, Rotimi C, Rotter JI, Rudan I, Den Ruijter HM, Sanghera DK, Sattar N, Schmidt R, Schulze MB, Schunkert H, Scott RA, Shuldiner AR, Sim X, Small N, Smith JA, Sotoodehnia N, Tai ES, Teumer A, Timpson NJ, Toniolo D, Tregouet DA, Tuomi T, Vollenweider P, Wang CA, Weir DR, Whitfield JB, Wijmenga C, Wong TY, Wright J, Yang J, Yu L, Zemel BS, Zonderman AB, Perola M, Magnusson PKE, Uitterlinden AG, Kooner JS, Chasman DI, Loos RJF, Franceschini N, Franke L, Haley CS, Hayward C, Walters RG, Perry JRB, Esko T, Helgason A, Stefansson K, Joshi PK, Kubo M, Wilson JF: Associations of autozygosity with a broad range of human phenotypes. Nat Commun 2019;10:4957. PMC6823371
  • Dai J, Li Z, Amos CI, Hung RJ, Tardon A, Andrew AS, Chen C, Christiani DC, Albanes D, van der Heijden E, Duell EJ, Rennert G, McKay JD, Yuan J-M, Field JK, Manjer J, Grankvist K, Le Marchand L, Teare MD, Schabath MB, Aldrich MC, Tsao MS, Lazarus P, Lam S, Bojesen SE, Arnold S, Wu X, Haugen A, Janout V, Johansson M, Brhane Y, Fernandez-Somoano A, Kiemeney LA, Davies MPA, Zienolddiny S, Hu Z, Shen H: Systematic analyses of regulatory variants in dnase i hypersensitive sites identified two novel lung cancer susceptibility loci. Carcinogenesis 2019;40:432-440
  • de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, Li C, Feitosa MF, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Deng X, Dorajoo R, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Evangelou E, Graff M, Alver M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Goel A, Hagemeijer Y, Harris SE, Hartwig FP, He M, Horimoto A, Hsu FC, Jackson AU, Kasturiratne A, Komulainen P, Kuhnel B, Laguzzi F, Lee JH, Luan J, Lyytikainen LP, Matoba N, Nolte IM, Pietzner M, Riaz M, Said MA, Scott RA, Sofer T, Stancakova A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Wang Y, Ware EB, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Ballantyne C, Boerwinkle E, Broeckel U, Campbell A, Canouil M, Charumathi S, Chen YI, Connell JM, de Faire U, de Las Fuentes L, de Mutsert R, de Silva HJ, Ding J, Dominiczak AF, Duan Q, Eaton CB, Eppinga RN, Faul JD, Fisher V, Forrester T, Franco OH, Friedlander Y, Ghanbari M, Giulianini F, Grabe HJ, Grove ML, Gu CC, Harris TB, Heikkinen S, Heng CK, Hirata M, Hixson JE, Howard BV, Ikram MA, InterAct C, Jacobs DR, Johnson C, Jonas JB, Kammerer CM, Katsuya T, Khor CC, Kilpelainen TO, Koh WP, Koistinen HA, Kolcic I, Kooperberg C, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lemaitre RN, Li Y, Liang J, Liu J, Liu K, Loh M, Louie T, Magi R, Manichaikul AW, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Mosley TH, Mukamal KJ, Nalls MA, Nauck M, Nelson CP, Sotoodehnia N, O'Connell JR, Palmer ND, Pazoki R, Pedersen NL, Peters A, Peyser PA, Polasek O, Poulter N, Raffel LJ, Raitakari OT, Reiner AP, Rice TK, Rich SS, Robino A, Robinson JG, Rose LM, Rudan I, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Shi Y, Sidney S, Sims M, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tan N, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, van Heemst D, Vuckovic D, Waldenberger M, Wang L, Wang Y, Wang Z, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yu B, Yu C, Yuan J-M, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Kamatani Y, Kato N, Kooner JS, Laakso M, Leander K, Lehtimaki T, Lifelines Cohort GTN, Magnusson PKE, Penninx B, Pereira AC, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wang YX, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Zheng W, Elliott P, North KE, Bouchard C, Evans MK, Gudnason V, Liu CT, Liu Y, Psaty BM, Ridker PM, van Dam RM, Kardia SLR, Zhu X, Rotimi CN, Mook-Kanamori DO, Fornage M, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Liu J, Rotter JI, Gauderman WJ, Province MA, Munroe PB, Rice K, Chasman DI, Cupples LA, Rao DC, Morrison AC: Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions. Am J Epidemiol 2019;188:1033-1054. PMC6545280
  • Dorajoo R, Chang X, Gurung RL, Li Z, Wang L, Wang R, Beckman KB, Adams-Haduch J, M Y, Liu S, Meah WY, Sim KS, Lim SC, Friedlander Y, Liu J, van Dam RM, Yuan J-M, Koh WP, Khor CC, Heng CK: Loci for human leukocyte telomere length in the singaporean chinese population and trans-ethnic genetic studies. Nat Commun 2019;10:2491. PMC6554354
  • Fanidi A, Carreras-Torres R, Larose TL, Yuan J-M, Stevens VL, Weinstein SJ, Albanes D, Prentice R, Pettinger M, Cai Q, Blot WJ, Arslan AA, Zeleniuch-Jacquotte A, McCullough ML, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Stampfer MJ, Smith-Warner SA, Giovannucci E, Giles GG, Hodge AM, Severi G, Johansson M, Grankvist K, Langhammer A, Brumpton BM, Wang R, Gao YT, Ericson U, Bojesen SE, Arnold SM, Koh WP, Shu XO, Xiang YB, Li H, Zheng W, Lan Q, Visvanathan K, Hoffman-Bolton J, Ueland PM, Midttun O, Caporaso NE, Purdue M, Freedman ND, Buring JE, Lee IM, Sesso HD, Michael Gaziano J, Manjer J, Relton CL, Hung RJ, Amos CI, Johansson M, Brennan P, consortium LC, the Tc: Is high vitamin b12 status a cause of lung cancer? Int J Cancer 2019;145:1499-1503. PMC6642017
  • Geng TT, Jafar TH, Yuan J-M, Koh WP: Sleep duration and risk of end-stage renal disease: The singapore chinese health study. Sleep Med 2019;54:22-27. PMC6380914
  • Geng TT, Jafar TH, Yuan J-M, Koh WP: Long-term incense use and the risk of end-stage renal disease among chinese in singapore: The singapore chinese health study. BMC Nephrol 2019;20:9. PMC6325774
  • Geng TT, Talaei M, Jafar TH, Yuan J-M, Koh WP: Pulse pressure and the risk of end-stage renal disease among chinese adults in singapore: The singapore chinese health study. J Am Heart Assoc 2019;8:e013282. PMC6912960
  • Huang T, Wang T, Heianza Y, Wiggs J, Sun D, Choi HK, Chai JF, Sim X, Khor CC, Friedlander Y, Chan AT, Curhan G, Vivo I, van Dam RM, Heng CK, Fuchs C, Pasquale LR, Yuan J-M, Hu FB, Koh WP, Qi L: Fish and marine fatty acids intakes, the fads genotypes and long-term weight gain: A prospective cohort study. BMJ Open 2019;9:e022877. PMC6678013
  • Jackson SS, Van Dyke AL, Zhu B, Pfeiffer RM, Petrick JL, Adami HO, Albanes D, Andreotti G, Beane Freeman LE, Berrington de Gonzalez A, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, McGee EE, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon RZ, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan J-M, Zeleniuch-Jacquotte A, Zhang X, McGlynn KA, Campbell PT, Koshiol J: Anthropometric risk factors for cancers of the biliary tract in the biliary tract cancers pooling project. Cancer Res 2019;79:3973-3982. PMC6759233
  • Kilpelainen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupovic H, Chasman DI, Manning A, Ntalla I, Aschard H, Brown MR, de Las Fuentes L, Franceschini N, Guo X, Vojinovic D, Aslibekyan S, Feitosa MF, Kho M, Musani SK, Richard M, Wang H, Wang Z, Bartz TM, Bielak LF, Campbell A, Dorajoo R, Fisher V, Hartwig FP, Horimoto A, Li C, Lohman KK, Marten J, Sim X, Smith AV, Tajuddin SM, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Evangelou E, Gao C, Graff M, Harris SE, He M, Hsu FC, Jackson AU, Zhao JH, Kraja AT, Kuhnel B, Laguzzi F, Lyytikainen LP, Nolte IM, Rauramaa R, Riaz M, Robino A, Rueedi R, Stringham HM, Takeuchi F, van der Most PJ, Varga TV, Verweij N, Ware EB, Wen W, Li X, Yanek LR, Amin N, Arnett DK, Boerwinkle E, Brumat M, Cade B, Canouil M, Chen YI, Concas MP, Connell J, de Mutsert R, de Silva HJ, de Vries PS, Demirkan A, Ding J, Eaton CB, Faul JD, Friedlander Y, Gabriel KP, Ghanbari M, Giulianini F, Gu CC, Gu D, Harris TB, He J, Heikkinen S, Heng CK, Hunt SC, Ikram MA, Jonas JB, Koh WP, Komulainen P, Krieger JE, Kritchevsky SB, Kutalik Z, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Leander K, Lemaitre RN, Lewis CE, Liang J, Lifelines Cohort S, Liu J, Magi R, Manichaikul A, Meitinger T, Metspalu A, Milaneschi Y, Mohlke KL, Mosley TH, Jr., Murray AD, Nalls MA, Nang EK, Nelson CP, Nona S, Norris JM, Nwuba CV, O'Connell J, Palmer ND, Papanicolau GJ, Pazoki R, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous DJ, Poveda A, Raitakari OT, Rich SS, Risch N, Robinson JG, Rose LM, Rudan I, Schreiner PJ, Scott RA, Sidney SS, Sims M, Smith JA, Snieder H, Sofer T, Starr JM, Sternfeld B, Strauch K, Tang H, Taylor KD, Tsai MY, Tuomilehto J, Uitterlinden AG, van der Ende MY, van Heemst D, Voortman T, Waldenberger M, Wennberg P, Wilson G, Xiang YB, Yao J, Yu C, Yuan J-M, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, de Faire U, Deary IJ, Elliott P, Esko T, Freedman BI, Froguel P, Gasparini P, Gieger C, Kato N, Laakso M, Lakka TA, Lehtimaki T, Magnusson PKE, Oldehinkel AJ, Penninx B, Samani NJ, Shu XO, van der Harst P, Van Vliet-Ostaptchouk JV, Vollenweider P, Wagenknecht LE, Wang YX, Wareham NJ, Weir DR, Wu T, Zheng W, Zhu X, Evans MK, Franks PW, Gudnason V, Hayward C, Horta BL, Kelly TN, Liu Y, North KE, Pereira AC, Ridker PM, Tai ES, van Dam RM, Fox ER, Kardia SLR, Liu CT, Mook-Kanamori DO, Province MA, Redline S, van Duijn CM, Rotter JI, Kooperberg CB, Gauderman WJ, Psaty BM, Rice K, Munroe PB, Fornage M, Cupples LA, Rotimi CN, Morrison AC, Rao DC, Loos RJF: Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun 2019;10:376. PMC6342931
  • Kim D, Chen C, Tysinger B, Park S, Chong MZ, Wang L, Zhao M, Yuan J-M, Koh WP, Yoong J, Bhattacharya J, Eggleston K: Smoking, life expectancy, and chronic disease in south korea, singapore, and the united states: A microsimulation model. Health Econ 2019. PMC7269831
  • Leung YY, Talaei M, Ang LW, Yuan J-M, Koh WP: Reproductive factors and risk of total knee replacement due to severe knee osteoarthritis in women, the singapore chinese health study. Osteoarthritis Cartilage 2019;27:1129-1137. PMC6646081
  • Lontos K, Tsagianni A, Yuan J-M, Normolle DP, Boyiadzis M, Hou JZ, Swerdlow SH, Dorritie KA: Location matters in early stage nodal diffuse large b-cell lymphoma. Leuk Lymphoma 2019;60:250-253
  • Lu Y, Wang Y, Liang X, Zou L, Ong CN, Yuan J-M, Koh WP, Pan A: Serum amino acids in association with prevalent and incident type 2 diabetes in a chinese population. Metabolites 2019;9. PMC6359471
  • Luu HN, Huang JY, Wang R, Adams-Haduch J, Jin A, Koh WP, Yuan J-M: Association between leukocyte telomere length and the risk of pancreatic cancer: Findings from a prospective study. PLoS ONE 2019;14:e0221697. PMC6715276
  • Luu HN, Qi M, Wang R, Adams-Haduch J, Miljkovic I, Opresko PL, Jin A, Koh WP, Yuan J-M: Association between leukocyte telomere length and colorectal cancer risk in the singapore chinese health study. Clin Transl Gastroenterol 2019;10:1-9. PMC6602767
  • Marklund M, Wu JHY, Imamura F, Del Gobbo LC, Fretts A, de Goede J, Shi P, Tintle N, Wennberg M, Aslibekyan S, Chen TA, de Oliveira Otto MC, Hirakawa Y, Eriksen HH, Kroger J, Laguzzi F, Lankinen M, Murphy RA, Prem K, Samieri C, Virtanen J, Wood AC, Wong K, Yang WS, Zhou X, Baylin A, Boer JMA, Brouwer IA, Campos H, Chaves PHM, Chien KL, de Faire U, Djousse L, Eiriksdottir G, El-Abbadi N, Forouhi NG, Gaziano JM, Geleijnse JM, Gigante B, Giles G, Guallar E, Gudnason V, Harris T, Harris WS, Helmer C, Hellenius ML, Hodge A, Hu FB, Jacques PF, Jansson JH, Kalsbeek A, Khaw KT, Koh WP, Laakso M, Leander K, Lin HJ, Lind L, Luben R, Luo J, McKnight B, Mursu J, Ninomiya T, Overvad K, Psaty BM, Rimm E, Schulze MB, Siscovick D, Skjelbo Nielsen M, Smith AV, Steffen BT, Steffen L, Sun Q, Sundstrom J, Tsai MY, Tunstall-Pedoe H, Uusitupa MIJ, van Dam RM, Veenstra J, Verschuren WMM, Wareham N, Willett W, Woodward M, Yuan J-M, Micha R, Lemaitre RN, Mozaffarian D, Riserus U, Cohorts for H, Aging Research in Genomic Epidemiology Fatty Acids Outcomes Research Consortium: Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality: An individual-level pooled analysis of 30 cohort studies. Circulation 2019;139:2422-2436. PMC6582360
  • McGee EE, Jackson SS, Petrick JL, Van Dyke AL, Adami HO, Albanes D, Andreotti G, Beane-Freeman LE, de Gonzalez AB, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon R, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan J-M, Zeleniuch-Jacquotte A, Zhang X, Zhu B, McGlynn KA, Campbell PT, Koshiol J: Smoking, alcohol, and biliary tract cancer risk: A pooling project of 26 prospective studies. J Natl Cancer Inst 2019;111:1263-1278. PMC6910180
  • Moore BF, Butler LM, Bachand AM, Salim A, Reynolds SJ, Wang R, Nelson TL, Peel JL, Murphy SE, Koh WP, Yuan J-M, Clark ML: Diet, secondhand smoke, and glycated hemoglobin (hba1c) levels among singapore chinese adults. Int J Environ Res Public Health 2019;16. PMC6950101
  • Muller DC, Larose TL, Hodge A, Guida F, Langhammer A, Grankvist K, Meyer K, Cai Q, Arslan AA, Zeleniuch-Jacquotte A, Albanes D, Giles GG, Sesso HD, Lee IM, Gaziano JM, Yuan J-M, Hoffman Bolton J, Buring JE, Visvanathan K, Le Marchand L, Purdue MP, Caporaso NE, Midttun O, Ueland PM, Prentice RL, Weinstein SJ, Stevens VL, Zheng W, Blot WJ, Shu XO, Zhang X, Xiang YB, Koh WP, Hveem K, Thomson CA, Pettinger M, Engstrom G, Brunnstrom H, Milne RL, Stampfer MJ, Han J, Johansson M, Brennan P, Severi G, Johansson M: Circulating high sensitivity c reactive protein concentrations and risk of lung cancer: Nested case-control study within lung cancer cohort consortium. BMJ 2019;364:k4981. PMC6315896
  • Oh CC, Jin A, Yuan J-M, Koh WP: Coffee, tea, caffeine, and risk of non-melanoma skin cancer in a chinese population: The singapore chinese health study. J Am Acad Dermatol 2019;81:395-402
  • Pan XF, Yuan J-M, Koh WP, Pan A: Weight change in relation to mortality in middle-aged and elderly chinese: The Singapore Chinese Health Study. Int J Obes 2019;43:1590-1600
  • Paul P, Koh WP, Jin A, Michel A, Waterboer T, Pawlita M, Wang R, Yuan J-M, Butler LM: Soy and tea intake on cervical cancer risk: The singapore chinese health study. Cancer Causes Control 2019;30:847-857
  • Perez-Paramo YX, Chen G, Ashmore JH, Watson CJW, Nasrin S, Adams-Haduch J, Wang R, Gao YT, Koh WP, Yuan J-M, Lazarus P: Nicotine-n'-oxidation by flavin monooxygenase enzymes. Cancer Epidemiol Biomarkers Prev 2019;28:311-320. PMC6363832
  • Raghu VK, Zhao W, Pu J, Leader JK, Wang R, Herman J, Yuan J-M, Benos PV, Wilson DO: Feasibility of lung cancer prediction from low-dose ct scan and smoking factors using causal models. Thorax 2019;74:643-649
  • *Samavat H, Wu AH, Ursin G, Torkelson CJ, Wang R, Yu MC, Yee D, Kurzer MS, Yuan J-M: Green tea catechin extract supplementation does not influence circulating sex hormones and insulin-like growth factor axis proteins in a randomized controlled trial of postmenopausal women at high risk of breast cancer. J Nutr 2019;149:619-627. PMC6461722
  • *Samavat H, Xun X, Jin A, Wang R, Koh WP, Yuan J-M: Association between prediagnostic leukocyte telomere length and breast cancer risk: The singapore chinese health study. Breast Cancer Res 2019;21:50. PMC6471852
  • Seah JYH, Koh WP, Yuan J-M, van Dam RM: Rice intake and risk of type 2 diabetes: The singapore chinese health study. Eur J Nutr 2019;58:3349-3360
  • Seah JYH, Ong CN, Koh WP, Yuan J-M, van Dam RM: A dietary pattern derived from reduced rank regression and fatty acid biomarkers is associated with lower risk of type 2 diabetes and coronary artery disease in chinese adults. J Nutr 2019;149:2001-2010. PMC6825830
  • Shivappa N, Wang R, Hebert JR, Jin A, Koh WP, Yuan J-M: Association between inflammatory potential of diet and risk of lung cancer among smokers in a prospective study in singapore. Eur J Nutr 2019;58:2755-2766
  • Soh AZ, Chee CBE, Wang YT, Yuan J-M, Koh WP: Diabetes and body mass index in relation to risk of active tuberculosis: A prospective population-based cohort. Int J Tuberc Lung Dis 2019;23:1277-1282
  • *Stacy SL, Buchanich JM, Ma ZQ, Mair C, Robertson L, Sharma RK, Talbott EO, Yuan J-M: Maternal obesity, birth size, and risk of childhood cancer development. Am J Epidemiol 2019;188:1503-1511. PMC6670047
  • Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Kilpelainen TO, Richard MA, Aslibekyan S, Bartz TM, Dorajoo R, Li C, Liu Y, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, He M, Horimoto A, Hsu FC, Jackson AU, Kammerer CM, Kasturiratne A, Komulainen P, Kuhnel B, Leander K, Lee WJ, Lin KH, Luan J, Lyytikainen LP, McKenzie CA, Nelson CP, Noordam R, Scott RA, Sheu WHH, Stancakova A, Takeuchi F, van der Most PJ, Varga TV, Waken RJ, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking DE, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cade B, Campbell A, Canouil M, Chakravarti A, Cocca M, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Dorr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Forouhi NG, Franco OH, Friedlander Y, Gao H, Gigante B, Gu CC, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hofman A, Howard BV, Hunt SC, Irvin MR, Jia Y, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Kooperberg CB, Krieger JE, Kubo M, Kutalik Z, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lee JH, Lehne B, Levy D, Lewis CE, Li Y, Lifelines Cohort S, Lim SH, Liu CT, Liu J, Liu J, Liu Y, Loh M, Lohman KK, Louie T, Magi R, Matsuda K, Meitinger T, Metspalu A, Milani L, Momozawa Y, Mosley TH, Jr., Nalls MA, Nasri U, O'Connell JR, Ogunniyi A, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous D, Raitakari OT, Renstrom F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Sims M, Sitlani CM, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Wilson G, Wojczynski MK, Xiang YB, Yao J, Yuan J-M, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, Weir DR, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimaki T, Liang KW, Magnusson PKE, Oldehinkel AJ, Pereira AC, Perls T, Rauramaa R, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Wickremasinghe AR, Wu T, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Hixson J, Kardia SLR, Kritchevsky SB, Psaty BM, van Dam RM, Arnett DK, Mook-Kanamori DO, Fornage M, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotimi CN, Bierut LJ, Zhu X, Cupples LA, Province MA, Rotter JI, Franks PW, Rice K, Elliott P, Caulfield MJ, Gauderman WJ, Munroe PB, Rao DC, Morrison AC: A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet 2019. PMC6644157
  • Talaei M, Koh WP, Yuan J-M, van Dam RM: Dash dietary pattern, mediation by mineral intakes, and the risk of coronary artery disease and stroke mortality. J Am Heart Assoc 2019;8:e011054. PMC6474936
  • Ugai T, Ito H, Oze I, Saito E, Rahman MS, Boffetta P, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Gao YT, Sadakane A, Tsuji I, Park SK, Nagata C, You SL, Pednekar MS, Tsugane S, Cai H, Yuan J-M, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Chen CJ, Yoo KY, Chia KS, Ahsan H, Zheng W, Inoue M, Kang D, Potter J, Matsuo K: Association of bmi, smoking, and alcohol with multiple myeloma mortality in asians: A pooled analysis of more than 800,000 participants in the asia cohort consortium. Cancer Epidemiol Biomarkers Prev 2019;28:1861-1867
  • Wang Y, Koh WP, Jensen MK, Yuan J-M, Pan A: Plasma fetuin-a levels and risk of type 2 diabetes mellitus in a chinese population: A nested case-control study. Diabetes Metab J 2019;43:474-486. PMC6712221
  • Wang Y, Sun L, Lin X, Yuan J-M, Koh WP, Pan A: Retinol binding protein 4 and risk of type 2 diabetes in singapore chinese men and women: A nested case-control study. Nutr Metab (Lond) 2019;16:3. PMC6329092
  • Wu J, Dong W, Pan XF, Feng L, Yuan J-M, Pan A, Koh WP: Relation of cigarette smoking and alcohol drinking in midlife with risk of cognitive impairment in late life: The singapore chinese health study. Age Ageing 2019;48:101-107. PMC6322505
  • Wu J, Song X, Chen GC, Neelakantan N, van Dam RM, Feng L, Yuan J-M, Pan A, Koh WP: Dietary pattern in midlife and cognitive impairment in late life: A prospective study in chinese adults. Am J Clin Nutr 2019;110:912-920. PMC6766457
  • Yang JJ, Yu D, Wen W, Saito E, Rahman S, Shu XO, Chen Y, Gupta PC, Gu D, Tsugane S, Xiang YB, Gao YT, Yuan J-M, Tamakoshi A, Irie F, Sadakane A, Tomata Y, Kanemura S, Tsuji I, Matsuo K, Nagata C, Chen CJ, Koh WP, Shin MH, Park SK, Wu PE, Qiao YL, Pednekar MS, He J, Sawada N, Li HL, Gao J, Cai H, Wang R, Sairenchi T, Grant E, Sugawara Y, Zhang S, Ito H, Wada K, Shen CY, Pan WH, Ahn YO, You SL, Fan JH, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W: Association of diabetes with all-cause and cause-specific mortality in asia: A pooled analysis of more than 1 million participants. JAMA Netw Open 2019a;2:e192696. PMC6481439
  • Yang JJ, Yu D, Wen W, Shu XO, Saito E, Rahman S, Gupta PC, He J, Tsugane S, Xiang YB, Gao YT, Koh WP, Tamakoshi A, Irie F, Sadakane A, Tsuji I, Kanemura S, Matsuo K, Nagata C, Chen CJ, Yuan J-M, Shin MH, Park SK, Pan WH, Qiao YL, Pednekar MS, Gu D, Sawada N, Li HL, Gao J, Cai H, Grant E, Tomata Y, Sugawara Y, Ito H, Wada K, Shen CY, Wang R, Ahn YO, You SL, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W: Tobacco smoking and mortality in asia: A pooled meta-analysis. JAMA Netw Open 2019b;2:e191474. PMC6450311
  • Yang K, Zhang Y, Saito E, Rahman MS, Gupta PC, Sawada N, Tamakoshi A, Gao YT, Koh WP, Shu XO, Tsuji I, Sadakane A, Nagata C, You SL, Yuan J-M, Shin MH, Chen Y, Pan WH, Pednekar MS, Tsugane S, Cai H, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Wang R, Ahn YO, Yoo KY, Ahsan H, Chia KS, Boffetta P, Kang D, Potter JD, Inoue M, Zheng W, Nan H: Association between educational level and total and cause-specific mortality: A pooled analysis of over 694 000 individuals in the asia cohort consortium. BMJ Open 2019;9:e026225. PMC6707688
  • Yii AC, Soh AZ, Chee CBE, Wang YT, Yuan J-M, Koh WP: Asthma, sinonasal disease, and the risk of active tuberculosis. J Allergy Clin Immunol Pract 2019;7:641-648 e641. PMC6363891
  • Yuan J-M, Grouls M, Carmella SG, Wang R, Heskin A, Jiang Y, Tan YT, Adams-Haduch J, Gao YT, Hecht SS: Prediagnostic levels of urinary 8-epi-prostaglandin F2alpha and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma. Carcinogenesis 2019;40:989-997
  • Bassig BA, Shu XO, Sjodin A, Koh WP, Gao YT, Adams-Haduch J, Davis M, Wang R, Xiang YB, Engel LS, Purdue MP, Ji BT, Yang G, Jones RS, Langseth H, Hosgood HD, Grimsrud TK, Seow WJ, Wong JYY, Hu W, Chen D, Zheng W, Yuan J-M, Lan Q, Rothman N: Prediagnostic blood levels of organochlorines and risk of non-hodgkin lymphoma in three prospective cohorts in china and singapore. Int J Cancer 2020;146:839-849
  • Boldry EJ, Yuan J-M, Carmella SG, Wang R, Tessier K, Hatsukami DK, Hecht SS, Tretyakova NY: Effects of 2-phenethyl isothiocyanate on metabolism of 1,3-butadiene in smokers. Cancer Prev Res (Phila) 2020;13:91-100
  • Chang X, Dorajoo R, Han Y, Wang L, Liu J, Khor CC, Low AF, Chan MY, Yuan J-M, Koh WP, Friedlander Y, Heng CK. Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population. Mol Genet Genomic Med 8:e1450, 2020.  PMC7549588.
  • 3. Chang X, Dorajoo R, Sun Y, Wang L, Ong CN, Liu J, Khor CC, Yuan J-M, Koh WP, Friedlander Y, Heng CK. Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population. Nutr J 19:119, 2020.  PMC7602302
  • Chua KY, Lim WS, Lin X, Yuan J-M, Koh WP: Handgrip strength and timed up-and-go (tug) test are predictors of short-term mortality among elderly in a population-based cohort in singapore. J Nutr Health Aging 2020;24:371-378
  • de Las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR, Guo X, Manning A, Chasman DI, Aschard H, Bartz TM, Bielak LF, Campbell A, Cheng CY, Dorajoo R, Hartwig FP, Horimoto A, Li C, Li-Gao R, Liu Y, Marten J, Musani SK, Ntalla I, Rankinen T, Richard M, Sim X, Smith AV, Tajuddin SM, Tayo BO, Vojinovic D, Warren HR, Xuan D, Alver M, Boissel M, Chai JF, Chen X, Christensen K, Divers J, Evangelou E, Gao C, Girotto G, Harris SE, He M, Hsu FC, Kuhnel B, Laguzzi F, Li X, Lyytikainen LP, Nolte IM, Poveda A, Rauramaa R, Riaz M, Rueedi R, Shu XO, Snieder H, Sofer T, Takeuchi F, Verweij N, Ware EB, Weiss S, Yanek LR, Amin N, Arking DE, Arnett DK, Bergmann S, Boerwinkle E, Brody JA, Broeckel U, Brumat M, Burke G, Cabrera CP, Canouil M, Chee ML, Chen YI, Cocca M, Connell J, de Silva HJ, de Vries PS, Eiriksdottir G, Faul JD, Fisher V, Forrester T, Fox EF, Friedlander Y, Gao H, Gigante B, Giulianini F, Gu CC, Gu D, Harris TB, He J, Heikkinen S, Heng CK, Hunt S, Ikram MA, Irvin MR, Kahonen M, Kavousi M, Khor CC, Kilpelainen TO, Koh WP, Komulainen P, Kraja AT, Krieger JE, Langefeld CD, Li Y, Liang J, Liewald DCM, Liu CT, Liu J, Lohman KK, Magi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mook-Kanamori DO, Nalls MA, Nelson CP, Norris JM, O'Connell J, Ogunniyi A, Padmanabhan S, Palmer ND, Pedersen NL, Perls T, Peters A, Petersmann A, Peyser PA, Polasek O, Porteous DJ, Raffel LJ, Rice TK, Rotter JI, Rudan I, Rueda-Ochoa OL, Sabanayagam C, Salako BL, Schreiner PJ, Shikany JM, Sidney SS, Sims M, Sitlani CM, Smith JA, Starr JM, Strauch K, Swertz MA, Teumer A, Tham YC, Uitterlinden AG, Vaidya D, van der Ende MY, Waldenberger M, Wang L, Wang YX, Wei WB, Weir DR, Wen W, Yao J, Yu B, Yu C, Yuan J-M, Zhao W, Zonderman AB, Becker DM, Bowden DW, Deary IJ, Dorr M, Esko T, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kammerer CM, Kato N, Lakka TA, Leander K, Lehtimaki T, Lifelines Cohort S, Magnusson PKE, Marques-Vidal P, Penninx B, Samani NJ, van der Harst P, Wagenknecht LE, Wu T, Zheng W, Zhu X, Bouchard C, Cooper RS, Correa A, Evans MK, Gudnason V, Hayward C, Horta BL, Kelly TN, Kritchevsky SB, Levy D, Palmas WR, Pereira AC, Province MM, Psaty BM, Ridker PM, Rotimi CN, Tai ES, van Dam RM, van Duijn CM, Wong TY, Rice K, Gauderman WJ, Morrison AC, North KE, Kardia SLR, Caulfield MJ, Elliott P, Munroe PB, Franks PW, Rao DC, Fornage M: Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Mol Psychiatry 2020. PMC7641978
  • Geng TT, Jafar TH, Yuan J-M, Koh WP: The impact of diabetes on the association between alcohol intake and the risk of end-stage kidney disease in the singapore chinese health study. J Diabetes 2020;12:583-593
  • *Huang JY, Larose TL, Luu HN, Wang R, Fanidi A, Alcala K, Stevens VL, Weinstein SJ, Albanes D, Caporaso NE, Purdue MP, Ziegler RG, Freedman ND, Lan Q, Prentice RL, Pettinger M, Thomson CA, Cai Q, Wu J, Blot WJ, Shu XO, Zheng W, Arslan AA, Zeleniuch-Jacquotte A, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Stampfer MJ, Han J, Giles GG, Hodge AM, Severi G, Johansson M, Grankvist K, Langhammer A, Hveem K, Xiang YB, Li HL, Gao YT, Visvanathan K, Ueland PM, Midttun O, Ulvi A, Buring JE, Lee IM, Sesso HD, Gaziano JM, Manjer J, Relton C, Koh WP, Brennan P, Johansson M, Yuan J-M: Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the lung cancer cohort consortium (lc3). Int J Cancer 2020;146:2394-2405. PMC6960354
  • *Huang JY, Luu HN, Butler LM, Midttun O, Ulvik A, Wang R, Jin A, Gao YT, Tan Y, Ueland PM, Koh WP, Yuan J-M: A prospective evaluation of serum methionine-related metabolites in relation to pancreatic cancer risk in two prospective cohort studies. Int J Cancer 2020;147:1917-1927
  • Jiang YW, Sheng LT, Pan XF, Feng L, Yuan J-M, Pan A, Koh WP: Meat consumption in midlife and risk of cognitive impairment in old age: The singapore chinese health study. Eur J Nutr 2020;59:1729-1738
  • Jiang YW, Sheng LT, Pan XF, Feng L, Yuan J-M, Pan A, Koh WP: Midlife dietary intakes of monounsaturated acids, n-6 polyunsaturated acids, and plant-based fat are inversely associated with risk of cognitive impairment in older singapore chinese adults. J Nutr 2020;150:901-909. PMC7138666
  • Leong A, Lim VJY, Wang C, Chai JF, Dorajoo R, Heng CK, van Dam RM, Koh WP, Yuan J-M, Jonas JB, Wang YX, Wei WB, Liu J, Reilly DF, Wong TY, Cheng CY, Sim X: Association of g6pd variants with hemoglobin a1c and impact on diabetes diagnosis in east asian individuals. BMJ Open Diabetes Res Care 2020;8. PMC7103857
  • Li H, Khor CC, Fan J, Lv J, Yu C, Guo Y, Bian Z, Yang L, Millwood IY, Walters RG, Chen Y, Yuan J-M, Yang Y, Hu C, Chen J, Chen Z, Koh WP, Huang T, Li L: Genetic risk, adherence to a healthy lifestyle, and type 2 diabetes risk among 550,000 chinese adults: Results from 2 independent asian cohorts. Am J Clin Nutr 2020;111:698-707. PMC7049535
  • Oh CC, Jin AZ, Yuan J-M, Koh WP: Fish intake and risk of nonmelanoma skin cancer in a chinese population: The singapore chinese health study. Clin Exp Dermatol 2020;45:461-463
  • Pan XF, Li Y, Franco OH, Yuan J-M, Pan A, Koh WP: Impact of combined lifestyle factors on all-cause and cause-specific mortality and life expectancy in chinese: The singapore chinese health study. J Gerontol A Biol Sci Med Sci 2020;75:2193-2199. PMC7566531
  • Seow WJ, Koh WP, Jin A, Wang R, Yuan J-M: Associations between tea and coffee beverage consumption and the risk of lung cancer in the singaporean chinese population. Eur J Nutr 2020;59:3083-3091
  • Sheng LT, Jiang YW, Pan XF, Feng L, Yuan J-M, Pan A, Koh WP: Association between dietary intakes of b vitamins in midlife and cognitive impairment in late-life: The singapore chinese health study. J Gerontol A Biol Sci Med Sci 2020;75:1222-1227. PMC7243584
  • Soloff AC, Jones KE, Powers AA, Murthy P, Wang Y, Russell KL, Byrne-Steele M, Lund AW, Yuan J-M, Monaco SE, Han J, Dhupar R, Lotze MT. HMGB1 Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions. Front Immunol 11:2027, 2020.  PMC7498625.
  • Song X, Wu J, Zhou Y, Feng L, Yuan J-M, Pan A, Koh WP: Reproductive and hormonal factors and risk of cognitive impairment among singapore chinese women. Am J Obstet Gynecol 2020;223:410 e411-410 e423. PMC7483640
  • Spracklen CN, Horikoshi M, Kim YJ, Lin K, Bragg F, Moon S, Suzuki K, Tam CHT, Tabara Y, Kwak SH, Takeuchi F, Long J, Lim VJY, Chai JF, Chen CH, Nakatochi M, Yao J, Choi HS, Iyengar AK, Perrin HJ, Brotman SM, van de Bunt M, Gloyn AL, Below JE, Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Petty LE, Zhang W, Morris AP, Adair LS, Akiyama M, Bian Z, Chan JCN, Chang LC, Chee ML, Chen YI, Chen YT, Chen Z, Chuang LM, Du S, Gordon-Larsen P, Gross M, Guo X, Guo Y, Han S, Howard AG, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Isono M, Jang HM, Jiang G, Jonas JB, Kamatani Y, Katsuya T, Kawaguchi T, Khor CC, Kohara K, Lee MS, Lee NR, Li L, Liu J, Luk AO, Lv J, Okada Y, Pereira MA, Sabanayagam C, Shi J, Shin DM, So WY, Takahashi A, Tomlinson B, Tsai FJ, van Dam RM, Xiang YB, Yamamoto K, Yamauchi T, Yoon K, Yu C, Yuan J-M, Zhang L, Zheng W, Igase M, Cho YS, Rotter JI, Wang YX, Sheu WHH, Yokota M, Wu JY, Cheng CY, Wong TY, Shu XO, Kato N, Park KS, Tai ES, Matsuda F, Koh WP, Ma RCW, Maeda S, Millwood IY, Lee J, Kadowaki T, Walters RG, Kim BJ, Mohlke KL, Sim X: Identification of type 2 diabetes loci in 433,540 east asian individuals. Nature 2020;582:240-245. PMC7292783
  • Talaei M, Feng L, Barrenetxea J, Yuan J-M, Pan A, Koh WP: Adiposity, weight change, and risk of cognitive impairment: The singapore chinese health study. J Alzheimers Dis 2020;74:319-329
  • Talaei M, Feng L, Yuan J-M, Pan A, Koh WP: Dairy, soy, and calcium consumption and risk of cognitive impairment: The singapore chinese health study. Eur J Nutr 2020;59:1541-1552. PMC6888923
  • *Thomas CE, Luu HN, Wang R, Adams-Haduch J, Jin A, Koh WP, Yuan J-M: Association between dietary tomato intake and the risk of hepatocellular carcinoma: The singapore chinese health study. Cancer Epidemiol Biomarkers Prev 2020;29:1430-1435. PMC7685773
  • *Thomas CE, Wang R, Adams-Haduch J, Murphy SE, Ueland PM, Midttun O, Brennan P, Johansson M, Gao YT, Yuan J-M: Urinary cotinine is as good a biomarker as serum cotinine for cigarette smoking exposure and lung cancer risk prediction. Cancer Epidemiol Biomarkers Prev 2020;29:127-132. PMC7695222
  • Wang Y, Jafar TH, Jin A, Yuan J-M, Koh WP: Dietary intakes of trace elements and the risk of kidney cancer: The singapore chinese health study. Nutr Cancer 2020:1-7
  • Wang Y, Koh WP, Sim X, Yuan J-M, Pan A: Multiple biomarkers improved prediction for the risk of type 2 diabetes mellitus in singapore chinese men and women. Diabetes Metab J 2020;44:295-306. PMC7188981
  • Wang Y, Yuan J-M, Pan A, Koh WP: Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a chinese population. BMJ Open Diabetes Res Care 2020;8. PMC7199153
  • Ying AF, Khan S, Wu Y, Jin A, Wong ASY, Tan EK, Yuan J-M, Koh WP, Tan LCS. Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study. Mov Disord 35:1765-1773, 2020.  PMC7754435.
  • Zheng X, Li Q, Li X, Zhang Y, Wu X, Wei Q, Cao S, Yang M, Lin Z, Liao Z, Qi J, Lv Q, Wang L, Li Y, Irwanto A, Cheng CY, Chai X, Khor CC, Heng CK, Koh WP, Yuan J-M, Bei J, Zhang F, Zhang X, Zeng Y, Shen Y, Liu J, Gu J: Analysis of 47 non-mhc ankylosing spondylitis susceptibility loci regarding associated variants across whites and han chinese. J Rheumatol 2020;47:674-681.
  • Behari J, Graham L, Wang R, Schirda C, Borhani AA, Methe BA, Li K, Morris A, Luu HN, Palmieri S, Yuan J-M: Dynamics of hepatic steatosis resolution and changes in gut microbiome with weight loss in nonalcoholic fatty liver disease. Obes Sci Pract 2021;7:217-225. PMC8019274
  • Chang X, Chua KY, Wang L, Liu J, Yuan J-M, Khor CC, Heng CK, Koh WP, Dorajoo R: Midlife leukocyte telomere length as an indicator for handgrip strength in late life. J Gerontol A Biol Sci Med Sci 2021;76:172-175. PMC7756687
  • Chang X, Gurung RL, Wang L, Jin A, Li Z, Wang R, Beckman KB, Adams-Haduch J, Meah WY, Sim KS, Lim WK, Davila S, Tan P, Teo JX, Yeo KK, M Y, Liu S, Lim SC, Liu J, van Dam RM, Friedlander Y, Koh WP, Yuan J-M, Khor CC, Heng CK, Dorajoo R: Low frequency variants associated with leukocyte telomere length in the singapore chinese population. Commun Biol 2021;4:519
  • Geng TT, Jafar TH, Neelakantan N, Yuan J-M, van Dam RM, Koh WP: Healthful dietary patterns and risk of end-stage kidney disease: The singapore chinese health study. Am J Clin Nutr 2021;113:675-683. PMC7948892
  • Jin K, Hung RJ, Thomas S, Le Marchand L, Matsuo K, Seow A, Shen H, Kok WP, Yuan J-M, Wu M, Li L, Zhao JK, Zhang ZF: Hormonal factors in association with lung cancer among asian women: A pooled analysis from the international lung cancer consortium. Int J Cancer 2021;148:2241-2254
  • Lin JH, Wen CP, Jiang CQ, Yuan J-M, Chen CJ, Ho SY, Gao W, Zhang W, Wang R, Chien YC, Xu L, Wu X, Jin YL, Koh WP, Hsu WL, Zhu F, Wen C, Zhu T, Lee JH, Mai ZM, Lung ML, Lam TH: Smoking and nasopharyngeal cancer: Individual data meta-analysis of six prospective studies on 334 935 men. Int J Epidemiol 2021
  • Luu HN, Behari J, Goh GB, Wang R, Jin A, Thomas CE, Clemente JC, Odegaard AO, Koh WP, Yuan J-M: Composite score of healthy lifestyle factors and risk of hepatocellular carcinoma: Findings from a prospective cohort study. Cancer Epidemiol Biomarkers Prev 2021;30:380-387. PMC7867589
  • Luu HN, Neelakantan N, Geng TT, Wang R, Goh GB, Clemente JC, Jin A, van Dam RM, Jia W, Behari J, Koh WP, Yuan J-M: Quality diet indexes and risk of hepatocellular carcinoma: Findings from the singapore chinese health study. Int J Cancer 2021;148:2102-2114
  • Luu HN, Wang R, Jin A, Koh WP, Yuan J-M: The association between dietary vitamin b12 and lung cancer risk: Findings from a prospective cohort study. Eur J Cancer Prev 2021;30:275-281. PMC8012225
  • Ostrin EJ, Bantis LE, Wilson DO, Patel N, Wang R, Kundnani D, Adams-Haduch J, Dennison JB, Fahrmann JF, Chiu HT, Gazdar A, Feng Z, Yuan J-M, Hanash SM: Contribution of a blood-based protein biomarker panel to the classification of indeterminate pulmonary nodules. J Thorac Oncol 2021;16:228-236
  • Samavat H, Luu HN, Beckman KB, Jin A, Wang R, Koh WP, Yuan J-M: Leukocyte telomere length, cancer incidence and all-cause mortality among chinese adults: Singapore chinese health study. Int J Cancer 2021;148:352-362
  • Soh AZ, Tan CTY, Mok E, Chee CBE, Yuan J-M, Larbi A, Koh WP: Adipokines and the risk of active tb: A nested case-control study. Int J Tuberc Lung Dis 2021;25:31-35
  • Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, Bosse Y, Lam S, Tsao MS, Tardon A, Chen C, Doherty J, Goodman G, Bojesen SE, Landi MT, Johansson M, Field JK, Bickeboller H, Wichmann HE, Risch A, Rennert G, Arnold S, Wu X, Melander O, Brunnstrom H, Le Marchand L, Liu G, Andrew A, Duell E, Kiemeney LA, Shen H, Haugen A, Johansson M, Grankvist K, Caporaso N, Woll P, Dawn Teare M, Scelo G, Hong YC, Yuan J-M, Lazarus P, Schabath MB, Aldrich MC, Albanes D, Mak R, Barbie D, Brennan P, Hung RJ, Amos CI, Christiani DC, Lin X: Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer. Genet Epidemiol 2021;45:99-114. PMC7855632
  • Wang Y, Jafar TH, Jin A, Yuan J-M, Koh WP: Dietary intakes of trace elements and the risk of kidney cancer: The singapore chinese health study. Nutr Cancer 2021;73:239-245. PMC7529837
  • Wu J, Cheng GH, Sheng LT, Feng L, Yuan J-M, Chee M, Pan A, Koh WP: Prospective associations between change in sleep duration and cognitive impairment: Findings from the singapore chinese health study. J Affect Disord 2021;281:125-130
  • Yang JJ, Yu D, Shu XO, Freedman ND, Wen W, Rahman S, Abe SK, Saito E, Gupta PC, He J, Tsugane S, Gao YT, Xiang YB, Yuan J-M, Tomata Y, Tsuji I, Sugawara Y, Matsuo K, Ahn YO, Park SK, Chen Y, Pan WH, Pednekar M, Gu D, Sawada N, Cai H, Li HL, Koh WP, Wang R, Zhang S, Kanemura S, Ito H, Shin MH, Wu PE, Yoo KY, Ahsan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W: Quantifying the association of low-intensity and late initiation of tobacco smoking with total and cause-specific mortality in asia. Tob Control 2021;30:328-335
  • Yuan J-M, Wang Y, Wang R, Luu HN, Adams-Haduch J, Koh WP, Gao YT, Behari J, Lotze MT: Serum il27 in relation to risk of hepatocellular carcinoma in two nested case-control studies. Cancer Epidemiol Biomarkers Prev 2021;30:388-395. PMC7867592
  • Zhou YF, Song XY, Pan XF, Feng L, Luo N, Yuan J-M, Pan A, Koh WP: Association between combined lifestyle factors and healthy ageing in chinese adults: The singapore chinese health study. J Gerontol A Biol Sci Med Sci 2021
  • Zhou YF, Song XY, Wu J, Chen GC, Neelakantan N, van Dam RM, Feng L, Yuan J-M, Pan A, Koh WP: Association between dietary patterns in midlife and healthy ageing in chinese adults: The singapore chinese health study. J Am Med Dir Assoc 2020
  • Zhu J, Smith-Warner SA, Yu D, Zhang X, Blot WJ, Xiang YB, Sinha R, Park Y, Tsugane S, White E, Koh WP, Park SK, Sawada N, Kanemura S, Sugawara Y, Tsuji I, Robien K, Tomata Y, Yoo KY, Kim J, Yuan J-M, Gao YT, Rothman N, Lazovich D, Abe SK, Rahman MS, Loftfield E, Takata Y, Li X, Lee JE, Saito E, Freedman ND, Inoue M, Lan Q, Willett WC, Zheng W, Shu XO: Associations of coffee and tea consumption with lung cancer risk. Int J Cancer 2020

Jian-Min  Yuan