Jian-Min Yuan, MD, PhD

Professor, Epidemiology

Arnold Palmer Endowed Chair in Cancer Prevention, UPMC Hillman Cancer Center

Associate Director, Cancer Control and Population Science, UPMC Hillman Cancer Center

Co-Leader, Cancer Epidemiology and Prevention, UPMC Hillman Cancer Center

Contact

University of Pittsburgh Medical Center (Shadyside) Cancer Pavilion, 5150 Centre Avenue - Suite 4C, Room 470, Pittsburgh, PA 15232
R-znvy: lhnaw@hczp.rqh
Primary Phone: 967-319-2334
Fax: 967-319-2383


Personal Statement

Dr. Yuan’s research focuses on the etiologic and protective roles of environmental exposures and genetic factors, and their interaction in the development of cancers. He is Principal Investigator (PI) of both the Shanghai Cohort Study and the Singapore Chinese Health Study ─ two population-based prospective cohort studies of more than 80,000 middle-aged men and women with available biospecimens collected at baseline and under surveillance for more than 25 years. He is also the current PI of the Pittsburgh Lung Screening Study that has collected repeated annual blood samples and biannual low-dose CT scans on a cohort of 3600 smokers at high risk for lung cancer.  The ultimate goal of Dr. Yuan’s research is to discover and validate biomarkers that can characterize individuals at high risk for cancer and early detection of cancer, and to identify natural agents for primary cancer prevention.  Dr. Yuan is passionate about teaching and training on graduate students and post-doctoral fellows. He is the Director of the Translational Research Training in Cancer Etiology and Prevention Program, a multi-disciplinary cross-college training program at University of Pittsburgh Cancer Institute and the Department of Epidemiology, and is PI  of the National Cancer Institute (NCI) funded T32 training grant.


Education

1983 | Shanghai Medical University | MD, Medicine
1986 | Shanghai Medical University | MPH, Public Health/Epidemiology
1996 | University of Southern California | PhD, Epidemiology


Research Interests

  • Environmental exposure and gene-environmental interaction in the etiology of cancer
  • Biomarkers for cancer risk assessment and early detection
  • Chemopreventive effect of dietary agents for primary prevention of cancer 


Research Support

Principal Investigator

08/05/2014-07/31/2024
NIH/NCI T32 CA186873
Research Training in Cancer Etiology and Prevention

09/16/2014-08/31/2020
NIH/NCI UM1CA182876
The Cancer Epidemiology Cohorts in Singapore and Shanghai

09/16/2019-08/31/2021 (NCE)
NIH/NCI U01CA182876
The Cancer Epidemiology Cohorts in Singapore and Shanghai

06/14/2017-05/31/2022
NIH/NCI R01CA213123
Randomized Clinical Trial of Lung Cancer Chemoprevention with Sulforaphane in Former Smokers

Co-Principal Investigator/Sub-contract PI/Program Leader

09/10/1997-07/31/2020
NIH/NCI P30CA047904 (Ferris)
Cancer Center Support Grant

09/21/2016– 08/30/2021
NIH/NCI P01CA138338 (Hecht)
Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking (Subcontract PI)

09/06/2017– 08/31/2022
NIH/NCI U01CA213285 (Hanash)
Development of Risk and Early Detection Biomarker for Small Cell Lung Cancer (Subcontract PI)

08/01/2017– 03/31/2023
NIH/NCI U19CA203654 (Amos/Brennan)
Integrative analysis of lung cancer etiology and risk, Project 2: Biomarkers of lung cancer risk (Subcontract PI) (Baylor College of Medicine/ IARC)

Co-Investigator

09/01/2016- 08/31/2021
NIH/NCI U01CA214165 (Herman)
Ultrasensitive Detection of Tumor Specific DNA Methylation Changes for the Early Detection of Lung Cancer


Selected Publications

  • Pan XF, Yuan J-M, Koh WP, Pan A. Weight change in relation to mortality in middle-aged and elderly Chinese: the Singapore Chinese Health Study. Int J Obes 43:1590-1600, 2019. [Indexed for MEDLINE]
  • Paul P, Koh WP, Jin A, Michel A, Waterboer T, Pawlita M, Wang R, Yuan J-M, Butler LM. Soy and tea intake on cervical cancer risk: the Singapore Chinese Health Study. Cancer Causes Control 30:847-857, 2019. [Indexed for MEDLINE]
  • Perez-Paramo YX, Chen G, Ashmore JH, Watson CJW, Nasrin S, Adams-Haduch J, Wang R, Gao YT, Koh WP, Yuan J-M, Lazarus P. Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes. Cancer Epidemiol Biomarkers Prev 28:311-320, 2019. PMC6363832.
  • Raghu VK, Zhao W, Pu J, Leader JK, Wang R, Herman J, Yuan J-M, Benos PV, Wilson DO. Feasibility of lung cancer prediction from low-dose CT scan and smoking factors using causal models. Thorax 74:643-649, 2019. PMC6585306
  • *Samavat H, Wu AH, Ursin G, Torkelson CJ, Wang R, Yu MC, Yee D, Kurzer MS, Yuan J-M. Green Tea Catechin Extract Supplementation Does Not Influence Circulating Sex Hormones and Insulin-Like Growth Factor Axis Proteins in a Randomized Controlled Trial of Postmenopausal Women at High Risk of Breast Cancer. J Nutr 149:619-627, 2019. PMC6461722.
  • Samavat H, Xun X, Jin A, Wang R, Koh WP, Yuan J-M. Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study. Breast Cancer Res 21:50, 2019. PMC6471852.
  • Seah JY, Ong CN, Koh WP, Yuan J-M, van Dam RM. A Dietary Pattern Derived from Reduced Rank Regression and Fatty Acid Biomarkers Is Associated with Lower Risk of Type 2 Diabetes and Coronary Artery Disease in Chinese Adults. J Nutr, 149:2001-2010, 2019. PMC6825830.
  • Sheng LT, Jiang YW, Pan XF, Feng L, Yuan J-M, Pan A, Koh WP. Association between Dietary Intakes of B Vitamins in Midlife and Cognitive Impairment in Late-Life: the Singapore Chinese Health Study. DOI: 10.1093/gerona/glz125, Gerontol A Biol Sci Med Sci, 2019. 
  • *Stacy SL, Buchanich JM, Ma ZQ, Mair C, Robertson L, Sharma RK, Talbott EO, Yuan J-M. Maternal Obesity, Birth Size, and Risk of Childhood Cancer Development. Am J Epidemiol 188:1503-1511, 2019. PMC6670047.
  • Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Kilpelainen TO, Richard MA, Aslibekyan S, Bartz TM, Dorajoo R, Li C, Liu Y, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, He M, Horimoto A, Hsu FC, Jackson AU, Kammerer CM, Kasturiratne A, Komulainen P, Kuhnel B, Leander K, Lee WJ, Lin KH, Luan J, Lyytikainen LP, McKenzie CA, Nelson CP, Noordam R, Scott RA, Sheu WHH, Stancakova A, Takeuchi F, van der Most PJ, Varga TV, Waken RJ, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking DE, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cade B, Campbell A, Canouil M, Chakravarti A, Cocca M, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Dorr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Forouhi NG, Franco OH, Friedlander Y, Gao H, Gigante B, Gu CC, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hofman A, Howard BV, Hunt SC, Irvin MR, Jia Y, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Kooperberg CB, Krieger JE, Kubo M, Kutalik Z, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lee JH, Lehne B, Levy D, Lewis CE, Li Y, Lifelines Cohort S, Lim SH, Liu CT, Liu J, Liu J, Liu Y, Loh M, Lohman KK, Louie T, Magi R, Matsuda K, Meitinger T, Metspalu A, Milani L, Momozawa Y, Mosley TH, Jr., Nalls MA, Nasri U, O'Connell JR, Ogunniyi A, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous D, Raitakari OT, Renstrom F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Sims M, Sitlani CM, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Wilson G, Wojczynski MK, Xiang YB, Yao J, Yuan J-M, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, Weir DR, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimaki T, Liang KW, Magnusson PKE, Oldehinkel AJ, Pereira AC, Perls T, Rauramaa R, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Wickremasinghe AR, Wu T, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Hixson J, Kardia SLR, Kritchevsky SB, Psaty BM, van Dam RM, Arnett DK, Mook-Kanamori DO, Fornage M, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotimi CN, Bierut LJ, Zhu X, Cupples LA, Province MA, Rotter JI, Franks PW, Rice K, Elliott P, Caulfield MJ, Gauderman WJ, Munroe PB, Rao DC, Morrison AC. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet, 2019. PMC6644157.
  • Talaei M, Feng L, Yuan J-M, Pan A, Koh WP. Dairy, soy, and calcium consumption and risk of cognitive impairment: the Singapore Chinese Health Study. Eur J Nutr, 2019. PMC6888923
  • Talaei M, Koh WP, Yuan J-M, van Dam RM. DASH Dietary Pattern, Mediation by Mineral Intakes, and the Risk of Coronary Artery Disease and Stroke Mortality. J Am Heart Assoc 8:e011054, 2019. PMC6474936.
  • Ugai T, Ito H, Oze I, Saito E, Rahman MS, Boffetta P, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Gao YT, Sadakane A, Tsuji I, Park SK, Nagata C, You SL, Pednekar MS, Tsugane S, Cai H, Yuan J-M, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Chen CJ, Yoo KY, Chia KS, Ahsan H, Zheng W, Inoue M, Kang D, Potter JD, Matsuo K. Association of BMI, smoking and alcohol with multiple myeloma mortality in Asians: a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium. DOI: 10.1158/1055-9965.EPI-19-0389, Cancer Epidemiol Biomarkers Prev. 28:1861-1867, 2019.
  • Wang Y, Koh WP, Jensen MK, Yuan J-M, Pan A. Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study. Diabetes Metab J 43:474-486, 2019. PMC6712221.
  • Wang Y, Sun L, Lin X, Yuan J-M, Koh WP, Pan A. Retinol binding protein 4 and risk of type 2 diabetes in Singapore Chinese men and women: a nested case-control study. Nutr Metab (Lond) 16:3, 2019. PMC6329092.
  • Wu J, Dong W, Pan XF, Feng L, Yuan J-M, Pan A, Koh WP. Relation of cigarette smoking and alcohol drinking in midlife with risk of cognitive impairment in late life: the Singapore Chinese Health Study. Age Ageing 48:101-107, 2019. PMC6322505.
  • Wu J, Song X, Chen GC, Neelakantan N, van Dam RM, Feng L, Yuan J-M, Pan A, Koh WP. Dietary pattern in midlife and cognitive impairment in late life: a prospective study in Chinese adults. Am J Clin Nutr, 110:912-920, 2019. PMC6766457
  • Yang JJ, Yu D, Wen W, Saito E, Rahman S, Shu XO, Chen Y, Gupta PC, Gu D, Tsugane S, Xiang YB, Gao YT, Yuan J-M, Tamakoshi A, Irie F, Sadakane A, Tomata Y, Kanemura S, Tsuji I, Matsuo K, Nagata C, Chen CJ, Koh WP, Shin MH, Park SK, Wu PE, Qiao YL, Pednekar MS, He J, Sawada N, Li HL, Gao J, Cai H, Wang R, Sairenchi T, Grant E, Sugawara Y, Zhang S, Ito H, Wada K, Shen CY, Pan WH, Ahn YO, You SL, Fan JH, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants. JAMA Netw Open 2:e192696, 2019. PMC6481439.
  • Yang JJ, Yu D, Wen W, Shu XO, Saito E, Rahman S, Gupta PC, He J, Tsugane S, Xiang YB, Gao YT, Koh WP, Tamakoshi A, Irie F, Sadakane A, Tsuji I, Kanemura S, Matsuo K, Nagata C, Chen CJ, Yuan J-M, Shin MH, Park SK, Pan WH, Qiao YL, Pednekar MS, Gu D, Sawada N, Li HL, Gao J, Cai H, Grant E, Tomata Y, Sugawara Y, Ito H, Wada K, Shen CY, Wang R, Ahn YO, You SL, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Tobacco Smoking and Mortality in Asia: A Pooled Meta-analysis. JAMA Netw Open 2:e191474, 2019. PMC6450311.
  • Yang K, Zhang Y, Saito E, Rahman MS, Gupta PC, Sawada N, Tamakoshi A, Gao YT, Koh WP, Shu XO, Tsuji I, Sadakane A, Nagata C, You SL, Yuan J-M, Shin MH, Chen Y, Pan WH, Pednekar MS, Tsugane S, Cai H, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Wang R, Ahn YO, Yoo KY, Ahsan H, Chia KS, Boffetta P, Kang D, Potter JD, Inoue M, Zheng W, Nan H. Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium. BMJ Open 9:e026225, 2019. PMC6707688.
  • Yii AC, Soh AZ, Chee CBE, Wang YT, Yuan J-M, Koh WP. Asthma, Sinonasal Disease, and the Risk of Active Tuberculosis. J Allergy Clin Immunol Pract 7:641-648 e641, 2019. PMC6363891.
  • Wang X, Leader JK, Wang R, Wilson D, Herman J, Yuan JM, Pu J.Erratum to "Vasculature surrounding a nodule: A novel lung cancer biomarker" [Lung Cancer 114 (December) (2017) 38-43]. DOI: 10.1016/j.lungcan.2019.07.018, Lung Cancer. 135:234, 2019.
  • Yuan J-M, Grouls M, Carmella SG, Wang R, Heskin A, Jiang Y, Tan YT, Adams-Haduch J, Gao YT, Hecht SS. Prediagnostic levels of urinary 8-epi-prostaglandin F2alpha and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma. DOI: 10.1093/carcin/bgy180, Carcinogenesis 40:989-997, 2019. [Indexed for MEDLINE]
  • Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Borst GJ, Bottinger EP, Broer L, Campbell H, Chanock S, Chee ML, Chen G, Chen YI, Chen Z, Chiu YF, Cocca M, Collins FS, Concas MP, Corley J, Cugliari G, van Dam RM, Damulina A, Daneshpour MS, Day FR, Delgado GE, Dhana K, Doney ASF, Dörr M, Doumatey AP, Dzimiri N, Ebenesersdóttir SS, Elliott J, Elliott P, Ewert R, Felix JF, Fischer K, Freedman BI, Girotto G, Goel A, Gögele M, Goodarzi MO, Graff M, Granot-Hershkovitz E, Grodstein F, Guarrera S, Gudbjartsson DF, Guity K, Gunnarsson B, Guo Y, Hagenaars SP, Haiman CA, Halevy A, Harris TB, Hedayati M, van Heel DA, Hirata M, Höfer I, Hsiung CA, Huang J, Hung YJ, Ikram MA, Jagadeesan A, Jousilahti P, Kamatani Y, Kanai M, Kerrison ND, Kessler T, Khaw KT, Khor CC, de Kleijn DPV, Koh WP, Kolcic I, Kraft P, Krämer BK, Kutalik Z, Kuusisto J, Langenberg C, Launer LJ, Lawlor DA, Lee IT, Lee WJ, Lerch MM, Li L, Liu J, Loh M, London SJ, Loomis S, Lu Y, Luan J, Mägi R, Manichaikul AW, Manunta P, Másson G, Matoba N, Mei XW, Meisinger C, Meitinger T, Mezzavilla M, Milani L, Millwood IY, Momozawa Y, Moore A, Morange PE, Moreno-Macías H, Mori TA, Morrison AC, Muka T, Murakami Y, Murray AD, de Mutsert R, Mychaleckyj JC, Nalls MA, Nauck M, Neville MJ, Nolte IM, Ong KK, Orozco L, Padmanabhan S, Pálsson G, Pankow JS, Pattaro C, Pattie A, Polasek O, Poulter N, Pramstaller PP, Quintana-Murci L, Räikkönen K, Ralhan S, Rao DC, van Rheenen W, Rich SS, Ridker PM, Rietveld CA, Robino A, van Rooij FJA, Ruggiero D, Saba Y, Sabanayagam C, Sabater-Lleal M, Sala CF, Salomaa V, Sandow K, Schmidt H, Scott LJ, Scott WR, Sedaghati-Khayat B, Sennblad B, van Setten J, Sever PJ, Sheu WH, Shi Y, Shrestha S, Shukla SR, Sigurdsson JK, Sikka TT, Singh JR, Smith BH, Stančáková A, Stanton A, Starr JM, Stefansdottir L, Straker L, Sulem P, Sveinbjornsson G, Swertz MA, Taylor AM, Taylor KD, Terzikhan N, Tham YC, Thorleifsson G, Thorsteinsdottir U, Tillander A, Tracy RP, Tusié-Luna T, Tzoulaki I, Vaccargiu S, Vangipurapu J, Veldink JH, Vitart V, Völker U, Vuoksimaa E, Wakil SM, Waldenberger M, Wander GS, Wang YX, Wareham NJ, Wild S, Yajnik CS, Yuan JM, Zeng L, Zhang L, Zhou J, Amin N, Asselbergs FW, Bakker SJL, Becker DM, Lehne B, Bennett DA, van den Berg LH, Berndt SI, Bharadwaj D, Bielak LF, Bochud M, Boehnke M, Bouchard C, Bradfield JP, Brody JA, Campbell A, Carmi S, Caulfield MJ, Cesarini D, Chambers JC, Chandak GR, Cheng CY, Ciullo M, Cornelis M, Cusi D, Smith GD, Deary IJ, Dorajoo R, van Duijn CM, Ellinghaus D, Erdmann J, Eriksson JG, Evangelou E, Evans MK, Faul JD, Feenstra B, Feitosa M, Foisy S, Franke A, Friedlander Y, Gasparini P, Gieger C, Gonzalez C, Goyette P, Grant SFA, Griffiths LR, Groop L, Gudnason V, Gyllensten U, Hakonarson H, Hamsten A, van der Harst P, Heng CK, Hicks AA, Hochner H, Huikuri H, Hunt SC, Jaddoe VWV, De Jager PL, Johannesson M, Johansson Å, Jonas JB, Jukema JW, Junttila J, Kaprio J, Kardia SLR, Karpe F, Kumari M, Laakso M, van der Laan SW, Lahti J, Laudes M, Lea RA, Lieb W, Lumley T, Martin NG, März W, Matullo G, McCarthy MI, Medland SE, Merriman TR, Metspalu A, Meyer BF, Mohlke KL, Montgomery GW, Mook-Kanamori D, Munroe PB, North KE, Nyholt DR, O'connell JR, Ober C, Oldehinkel AJ, Palmas W, Palmer C, Pasterkamp GG, Patin E, Pennell CE, Perusse L, Peyser PA, Pirastu M, Polderman TJC, Porteous DJ, Posthuma D, Psaty BM, Rioux JD, Rivadeneira F, Rotimi C, Rotter JI, Rudan I, Den Ruijter HM, Sanghera DK, Sattar N, Schmidt R, Schulze MB, Schunkert H, Scott RA, Shuldiner AR, Sim X, Small N, Smith JA, Sotoodehnia N, Tai ES, Teumer A, Timpson NJ, Toniolo D, Tregouet DA, Tuomi T, Vollenweider P, Wang CA, Weir DR, Whitfield JB, Wijmenga C, Wong TY, Wright J, Yang J, Yu L, Zemel BS, Zonderman AB, Perola M, Magnusson PKE, Uitterlinden AG, Kooner JS, Chasman DI, Loos RJF, Franceschini N, Franke L, Haley CS, Hayward C, Walters RG, Perry JRB, Esko T, Helgason A, Stefansson K, Joshi PK, Kubo M, Wilson JF. Associations of autozygosity with a broad range of human phenotypes. Nat Commun. 10:4957, 2019. PMC6823371
  • Pan XF, Li Y, Franco OH, Yuan JM, Pan A, Koh WP. Impact of combined lifestyle factors on all-cause and cause-specific mortality and life expectancy in Chinese: the Singapore Chinese Health Study. doi: 10.1093/gerona/glz271, 2019. J Gerontol A Biol Sci Med Sci. [Epub ahead of print]
  • Geng TT, Talaei M, Jafar TH, Yuan JM, Koh WP. Pulse Pressure and the Risk of End-Stage Renal Disease Among Chinese Adults in Singapore: The Singapore Chinese Health Study. J Am Heart Assoc. 8:e013282, 2019. PMC6912960
  • Kim D, Chen C, Tysinger B, Park S, Chong MZ, Wang L, Zhao M, Yuan JM, Koh WP, Yoong J, Bhattacharya J, Eggleston K. Smoking, life expectancy, and chronic disease in South Korea, Singapore, and the United States: A microsimulation model. Health Econ. Dec 4. doi: 10.1002/hec.3978, 2019. [Epub ahead of print]
  • Seow WJ, Koh WP, Jin A, Wang R, Yuan JM. Associations between tea and coffee beverage consumption and the risk of lung cancer in the Singaporean Chinese population. Eur J Nutr. doi: 10.1007/s00394-019-02146-7, 2019 [Epub ahead of print]
  • Moore BF, Butler LM, Bachand AM, Salim A, Reynolds SJ, Wang R, Nelson TL, Peel JL, Murphy SE, Koh WP, Yuan JM, Clark ML. Diet, Secondhand Smoke, and Glycated Hemoglobin (HbA1c) Levels among Singapore Chinese Adults. Int J Environ Res Public Health. 16: doi: 10.3390/ijerph16245148, 2019. PMC6950101.
  • Zheng X, Li Q, Li X, Zhang Y, Wu X, Wei Q, Cao S, Yang M, Lin Z, Liao Z, Qi J, Lv Q, Wang L, Li Y, Irwanto A, Cheng CY, Chai X, Khor CC, Heng CK, Koh WP, Yuan JM, Bei J, Zhang F, Zhang X, Zeng Y, Shen Y, Liu J, Gu J. Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese. doi: 10.3899/jrheum.190184, J Rheumatol 47:674-681, 2020.
  • Boldry EJ, Yuan JM, Carmella SG, Wang R, Tessier K, Hatsukami DK, Hecht SS, Tretyakova NY. Effects of 2-Phenethyl Isothiocyanate on Metabolism of 1,3-Butadiene in Smokers. DOI: 10.1158/1940-6207.CAPR-19-0296, Cancer Prev Res (Phila). 13:91-100, 2020.
  • Wang Y, Koh WP, Sim X, Yuan JM, Pan A. Multiple Biomarkers Improved Prediction for the Risk of Type 2 Diabetes Mellitus in Singapore Chinese Men and Women. DOI: 10.4093/dmj.2019.0020, Diabetes Metab J. 44:295-306, 2020. PMC7188981
  • Wang Y, Yuan JM, Pan A, Koh WP. Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population. BMJ Open Diabetes Res Care. 8(1), pii: e001051, 2020. PMC7199153
  • Thomas CE, Wang R, Adams-Haduch J, Murphy SE, Ueland PM, Midttun Ø, Brennan P, Johansson M, Gao YT, Yuan JM. Urinary Cotinine Is as Good a Biomarker as Serum Cotinine for Cigarette Smoking Exposure and Lung Cancer Risk Prediction. DOI: 10.1158/1055-9965.EPI-19-0653Cancer Epidemiol Biomarkers Prev., 29:127-132, 2020.
  • Jiang YW, Sheng LT, Pan XF, Feng L, Yuan JM, Pan A, Koh WP. Midlife Dietary Intakes of Monounsaturated Acids, n-6 Polyunsaturated Acids, and Plant-Based Fat Are Inversely Associated with Risk of Cognitive Impairment in Older Singapore Chinese Adults. J Nutr. 150:901-909, 2020.
  • Li H, Khor CC, Fan J, Lv J, Yu C, Guo Y, Bian Z, Yang L, Millwood IY, Walters RG, Chen Y, Yuan JM, Yang Y, Hu C, Chen J, Chen Z, Koh WP, Huang T, Li L. Genetic risk, adherence to a healthy lifestyle, and type 2 diabetes risk among 550,000 Chinese adults: results from 2 independent Asian cohorts. Am J Clin Nutr., 111:698-707, 2020, PMC7049535
  • Talaei M, Feng L, Barrenetxea J, Yuan JM, Pan A, Koh WP. Adiposity, Weight Change, and Risk of Cognitive Impairment: The Singapore Chinese Health Study. DOI: 10.3233/JAD-191052, J Alzheimers Dis., 74:319-329, 2020.
  • Song X, Wu J, Zhou Y, Feng L, Yuan JM, Pan A, Koh WP. Reproductive and hormonal factors and risk of cognitive impairment among Singapore Chinese women. doi: 10.1016/j.ajog.2020.02.032, Am J Obstet Gynecol. pii: S0002-9378 (20)30220-9, 2020. [Epub ahead of print]
  • Geng TT, Jafar TH, Yuan JM, Koh WP. The impact of diabetes on the association between alcohol intake and the risk of end-stage kidney disease in the Singapore Chinese Health Study. doi: 10.1111/1753-0407.13034, J Diabetes. Mar 6, 2020 [Epub ahead of print]
  • Leong A, Lim VJY, Wang C, Chai JF, Dorajoo R, Heng CK, van Dam RM, Koh WP, Yuan JM, Jonas JB, Wang YX, Wei WB, Liu J, Reilly DF, Wong TY, Cheng CY, Sim X. Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals. doi: 10.1136/bmjdrc-2019-001091, BMJ Open Diabetes Res Care. 8. pii: e001091, 2020. PMC7103857
  • Huang JY, Luu HN, Butler LM, Midttun Ø, Ulvik A, Wang R, Jin A, Gao YT, Tan Y, Ueland PM, Koh WP, Yuan JM.  A prospective evaluation of serum methionine-related metabolites in relation to pancreatic cancer risk in two prospective cohort studies. doi: 10.1002/ijc.32994, Int J Cancer. Mar 29, 2020. [Epub ahead of print]
  • Wang Y, Jafar TH, Jin A, Yuan JM, Koh WP. Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study. doi: 10.1080/01635581.2020.1743870, Nutr Cancer. 2:1-7, 2020. [Epub ahead of print]
  • Thomas CE, Luu HN, Wang R, Adams-Haduch J, Jin A, Koh WP, Yuan JM. Association between dietary tomato intake and the risk of hepatocellular carcinoma: the Singapore Chinese Health Study. doi: 10.1158/1055-9965.EPI-20-0051, Cancer Epidemiol Biomarkers Prev, 2020. [Epub ahead of print]

Jian-Min  Yuan