Emma J.M. Barinas-Mitchell, PhD

Assistant Professor, Epidemiology

Assistant Professor, Clinical Translation and Science

Director, Ultrasound Research Laboratory

Contact

130 N. Bellefield Avenue, Suite 531, University of Pittsburgh , Pittsburgh, PA 15213
R-znvy: rwo9@cvgg.rqh
Primary Phone: 967-179-8923
Web site:

Personal Statement

Dr. Barinas-Mitchell’s research focuses on the application of subclinical vascular measures to the study of the natural history and prevention of CVD. As Co-Director (2006-2012) and Director (December 2012-present) of the University of Pittsburgh Ultrasound Research Lab (URL), she has collaborated on the application of early markers of vascular aging for >20 NIH-funded observational and intervention studies, including study design and implementation, oversight of collection of primary and secondary vascular outcome measures, data management and analyses of these vascular measures, and interpretation of these data for presentation and >60 peer-reviewed publications. She is also actively involved in research on vascular aging in women and in investigating the role of obesity, related cardiometabolic disturbances, and race/ethnicity in the development and progression of subclinical CVD.  Dr. Barinas-Mitchell is one of the Co-Directors of the CVD Epidemiology T32 training program and actively mentors students and trainees at the master's, doctoral and post-doctoral level.

Education

1991 | Bryn Mawr College, Bryn Mawr, PA | BA Chemistry
1998 | University of Pittsburgh, Pittsburgh, PA | PhD Epidemiology
2001 | University of Pittsburgh,Pittsburgh, PA | Post-doctoral training in CVD Epidemiology
 

Teaching

EPIDEM 2152: Workshop in Cardiovascular Disease Epidemiology (2007-2012, Co-Instructor; 2012- Present, Instructor)
EPIDEM 2150: Epidemiology Cardiovascular Diseases (2011-Present, Guest Lecturer)   

BCHS 2526: Health Equity Research Methods (2015-2019, Guest Lecturer)                                                                                               

Co-Director, CVD Training Program (2012-Present)

Research Interests

  • Application of subclinical CVD methodology in CVD epidemiology research
  • Cardiometabolic risk factors related to vascular aging
  • Racial/ethnic disparities in CVD risk
  • Vascular aging in midlife women

Research Support

Active Research Support:

Co-Investigator

  • Menopausal Vasomotor Symptoms as a Marker of Brain Aging in Women (NIA)  2016-2021 (PI: R. Thurston)
  • Vascular Moderators of Amyloid-Related Decline:From normal cognition to dementia (NIA) 2016-2021 (PI: O.Lopez)
  • Study of Women's Health Across the Nation - Coordinating Center (NIA) 2009-2012 (PI: K Sutton-Tyrrell), 2012- 2019 (PI: M Brooks)   
  • Multicenter Study on Exceptional Survival in Families (NIA) 2014-2019 (PI:A Newman)   
  • Depression and Subsequent Cardiac Risk Factors (NHLBI) 2015-2019 (PI:  M Kovacs)
  • Sleep, Circadian Rhythms, and Cardiometabolic Risk (NIA) 2015-2020 (PI:D Buysse)
  • Social Stressors and Atherosclerosis in Women with Lupus (NIAMSD) 2017-2021 (PI: T Lewis)
  • Expectations of Discrimination and CVD Risk in Women (NHLBI) 2017-2019 (PI: T Lewis)

Completed Research Support (past 4 years):

Co-Investigator

  • Role of Femoral Atherosclerosis in Functional Status, CVD Events and Mortality (NHLBI) 2013-2017 (PI: C Wassel)
  • Mechanisms Linking Hot Flashes to Cardiovascular Risk (NHLBI) 2011-2016 (PI: R Thurston)
  • Resistance and Cardiorespiratory Time-matched Exercise in Youth (NHLBI) 2013-2018 (PI:S Lee)

ORCID ID

0000-0002-7280-7781

Selected Publications

A complete list of published work can be found in MyBibliography:

http://www.ncbi.nlm.nih.gov/sites/myncbi/emma.barinas-mitchell.1/bibliography/40073245/public/?sort=date&direction=descending

Khan ZA, Janssen I, Mazzarelli JK, Powell LH, Dumasius A, Everson-Rose, SA, Barinas-Mitchell E, Matthews K, El Khoudary SR, Weinstock PJ, Hollenberg SM. Serial Studies in Subclinical Atherosclerosis During Menopausal Transition (From the Study of Women's Health Across the Nation). American Journal of Cardiology.  2018 Oct; 122(7): 1161-1168. PMID: 30077316. PMCID: PMC6345556.

Niemczyk NA, Catov JM, Desai M, McClure CK, Roberts JM, Sekikawa A, Tepper PG, Barinas-Mitchell E. Brachial Artery Stiffening in Healthy Primigravidas is Associated with Weight Gain and Increased Cardiac Output. Hypertens Pregnancy 2018 Nov;37(4):204-211. doi: 10.1080/10641955.2018.1524479. Epub 2018 Sep 26.PubMed PMID: 30257118; PubMed Central PMCID: PMC6330891.

Duan C, Talbott EO, Brooks MM, Park SK, Broadwin R, Matthews KA, Barinas-Mitchell E. Five-year exposure to PM2.5 and ozone and subclinical atherosclerosis in late midlife women: The Study of Women's Health Across the Nation. Int J Hyg Environ Health. 2018 Sep 17. pii: S1438-4639(18)30155-X. doi:10.1016/j.ijheh.2018.09.001. [Epub ahead of print] PubMed PMID: 30236459.

Catov J, Snyder GG, Bullen BB, Barinas-Mitchell EJM, Holzman C. Women with preterm birth have evidence of subclinical atherosclerosis a decade after delivery. Journal of Women’s Health 2019 May;28(5):621-627. doi: 10.1089/jwh.2018.7148. Epub 2018 Nov 2.PMID: 30388049.

Cortés YL, Parikh N, Allison MA, Criqui MH, Egnot NS, Barinas-Mitchell E, Wassel CL. Women’s Reproductive History and Pre-Clinical Peripheral Arterial Disease in Late Life: The San Diego Population Study. Journal of Women’s Health (Larchmt). 2018 Dec. {Epub ahead of print}. PMID: 30508411.

Cortes YI, Catov JM, Brooks M, Harlow SD, Isasi CR, Jackson EA, Matthews KA, Thurston RC, Barinas-Mitchell E. History of Adverse Pregnancy Outcomes, Blood Pressure, and Subclinical Vascular Measures in Late Midlife: SWAN (Study of Women’s Health Across the Nation). J Am Heart Assoc.2018;7(1).PubMed PMID: 29288157; PubMed CentralPMCID: PMC5778964.*
 

Egnot NS, Barinas-Mitchell E, Criqui MH, Allison MA, Ix JH, Jenny NS, Wassel CL. An exploratory factor analysis of inflammatory and coagulation markers associated with femoral artery atherosclerosis in the San Diego Population Study. Thromb Res. 2018 Feb 13;164:9-14. doi: 10.1016/j.thromres.2018.02.003. PubMed PMID: 29459247.  

Thurston RC, Barinas-Mitchell E, von Känel R, Chang Y, Koenen KC, Matthews KA. Trauma exposure and endothelial function among midlife women. Menopause. 2018 Apr;25(4):368-374. doi: 10.1097/GME.0000000000001036. PubMed PMID: 29206773; PubMed Central PMCID: PMC5866191.   
 
Vishnu A, Choo J, Hisamatsu T, Ahuja V, Masaki K, Miura K, Shin C, Long DL, Nakamura Y, Barinas-Mitchell E, Sekikawa A, Ueshima H, Evans R, Kadota A, Fujiyoshi A. Comparison of Carotid Plaque Burden among Healthy Middle-Aged Men Living in the US, Japan, and South Korea. Int Jour Cardiology. 2018 (in Press).
 
Thurston RC, Bhasin S, Chang Y, Barinas-Mitchell E, Matthews KA, Jasuja R, Santoro N. Reproductive Hormones and Subclinical Cardiovascular Disease in Midlife Women. The Journal of Clinical Endocrinology and Metabolism, jc.2018-00579. 2018 May. DOI: 10.1210.8.     
 
Wassel, CL, Ellia, AM. Suder NC, Barinas-Mitchell E, Rifkin DE, Forbang NI, Denenberg JO, Marasco AM, McQuaide BJ, Jenny NS, Allison MA, Ix JH, Criqui MH. Femoral Artery Atherosclerosis is associated with Physical Function across the Spectrum of the Ankle Brachial Index: The San Diego Population Study (SDPS). JAHA 2017 2017 Jul 20;6(7). pii: e005777. doi: 10.1161/JAHA.117.005777. PubMed PMID: 28729408; PubMed Central PMCID: PMC5586297.

 

Thurston RC, Chang Y, Barinas-Mitchell E, Jennings JR, von KänelR, Landsittel DP, Matthews KA. Physiologically assessed hot flashes and endothelial function among midlife women. Menopause2017; Aug; 24(8): 886-893. PMID: 28399007.

Hsu S, Rifkin DE, Criqui MH, Suder NC, Garimella P, Ginsberg C, Marasco AM, McQuaide BJ, Barinas-Mitchell EJ, Allison MA, Wassel CL, Ix JH. Relationship of Femoral Artery Ultrasound Measures of Atherosclerosis with Chronic Kidney Disease. J Vasc Surg. 2017 Dec 22. pii: S0741-5214(17)32513-2. doi:10.1016/j.jvs.2017.09.048. [Epub ahead of print] PubMed PMID: 29276107.

Thurston RC, Chang Y, Barinas-Mitchell E, von Känel R, Jennings JR, Santoro N, Landsittel DP, Matthews KA. Child Abuse and Neglect and Subclinical Cardiovascular Disease Among Midlife Women. Psychosom Med. 2017 May; 79 (4): 441-449.PMID: 27763988.

Matthews KA, El Khoudary SR, Brooks MM, Derby CA, Harlow SD, Barinas-Mitchell EJ, Thurston RC. Lipid changes around the final menstrual period predict carotid subclinical disease in postmenopausal women. Stroke 2017; 48 (1): 70-76. PMID 27909203; PMCID: PMC5183479.

Lott M, Kriska A, Barinas-Mitchell E, Wang L, Storti K, Winger D, Conroy M. Impact of Lifestyle Strategies on Long-Term Physical Activity and Weight. Journal of Physical Activity and Health. 2017. Aug; 14(8): 606-611. PMID: 28422536.

Emma J.M. Barinas-Mitchell