Amy L Hartman, PhD

Dr. Hartman received her bachelor's degree in Biology from Washington and Jefferson College in 1998. She received her Ph.D. in Molecular Virology from the Department of Molecular Genetics and Biochemistry at the University of Pittsburgh School of Medicine in 2003. Her graduate thesis was done in the laboratory of Mickey Murphey-Corb, Ph.D. and focused on host factors controlling Simian Immunodeficiency Virus (SIV) infection in rhesus macaques.

Dr. Hartman then did a post-doctoral fellowship in the Special Pathogens Branch at the Centers for Disease Control and Prevention in Atlanta, GA under Stuart Nichol, Ph.D. Her work focused on viral virulence factors contributing to severe disease induced by infection with Ebola Zaire virus. During her time at CDC, Dr. Hartman was a member of the outbreak response team sent to Angola in 2005 during the largest recorded outbreak of Marburg Hemorrhagic Fever.  Dr. Hartman assisted with setup and operation of the molecular diagnostic laboratory, which used Taqman PCR to diagnose patient clinical samples.  

Dr. Hartman returned to the University of Pittsburgh in 2007 as the Research Manager of the Regional Biocontainment Laboratory with a primary faculty appointment in the Department of Infectious Disease and Microbiology (IDM) in the Graduate School of Public Health (GSPH).

 

1998 | Washington and Jefferson College, Washington, PA | BA
2003 | University of Pittsburgh School of Medicine, Pittsburgh, PA | PhD 

Course Director:  

IDM2004 - Viral Pathogenesis (fall term)

Visit our lab website at: https://www.hartmanlab.com/

Dr. Hartman's broad research interests center on understanding the pathogenic mechanisms of RNA viruses, particularly arboviruses (viruses transmitted by insect vectors).  The focus of her research is on arboviruses that have the potential to spread to new locations (emerging viruses), as well as those that have the potential for misuse through bioterrorism.  In addition to understanding the disease-causing mechanisms of these viruses, Dr. Hartman works closely with the Department of Defense to assist in the testing of new treatments and vaccines to protect U.S. military personnel from exposure to virulent viruses.  Current research projects in Dr. Hartman's lab focus on Rift Valley Fever virus and the alphaviruses (Eastern, Western, and Venezuelan equine encephalitis viruses).

Rift Valley Fever virus (RVFV) is a mosquito-borne virus that causes severe disease in livestock and humans in Africa and the Arabian peninsula. Rift Valley Fever is found endemically in these regions, and rainfall alterations can lead to epizootics in livestock and epidemics in humans. RVFV is easily transmitted when humans handle infected animal carcasses, and this transmission is thought to be by mucosal exposure or direct inhalation of virus particles. Due to its ability to infect by the aerosol route, RVFV is also considered a potential bioterror threat. For these reasons, better vaccines and therapeutics for this globally-important emerging infectious disease are needed. 

Rift Valley Fever is included on the World Health Organization's 2018 list of prioritized diseases likely to cause major epidemics in the near future, including Rift Valley Fever.  In January of 2016, Science magazine named Rift Valley Fever as one of the top 10 diseases for which a vaccine is urgently needed.

Current research projects in Dr. Hartman's lab focus on 1) the neuropathogenesis of RVFV; 2) mechanisms of vertical transmission of RVFV; 3) design and evaluation of novel therapeutics and vaccines to treat RVF disese, particularly encephalitis. Dr. Hartman has established the first well-characterized models of the neurological disease that is seen in some RVFV-infected people. These models are currently being used to understand how the virus causes lethal encephalitis. Dr. Hartman's models have also been used to test novel antiviral drugs, such as Favipiravir (T-705), to determine its broad-spectrum applicability to treat emerging diseases. Dr. Hartman's lab recently published on the potential for vertical transmission of RVFV during pregnancy. 

Dr. Hartman's lab at the University of Pittsburgh Regional Biocontainment Laboratory has the necessary federal approvals to work at BSL-3, advanced equipment, and trained staff to successfully implement large research grants and contracts aimed at understanding the pathogenesis of infectious diseases.

PREPRINT: SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients. Preprint: BioRxiv https://www.biorxiv.org/content/10.1101/2020.06.19.154930v2 

PREPRINT: SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts. Preprint: BioRxiv https://www.biorxiv.org/content/10.1101/2020.06.20.137687v1

IN PRESS: Fears, A.C., W.B. Klimstra, P.D. Duprex, A.L. Hartman, S.C. Weaver, K.S. Plante, D. Mirchandani, J. Plante, P.V. Aguilar, D. Fernandez, A. Nalca, A. Totura, D. Dyer, B. Kearney, M. Lackemeyer, J.K. Bohannon, R. Johnson, R.F. Garry, D.S. Reed, C.J. Roy. In press. Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions. Accepted 6/8/20 at Emerging Infectious Diseases. Preprint: medRxiv https://doi.org/10.1101/2020.04.13.20063784

IN PRESS: Ma, H., J.D. Lundy, E.L. Cottle, K.J. O’Malley, A.M. Trichel, W.B. Klimstra, A.L. Hartman, D.S. Reed, T. Teichert. In press. Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis. Accepted 6/1/20 at PLOS One. Preprint: BioRxiv https://doi.org/10.1101/2020.04.15.042606

For incoming MS students starting in the fall of 2020:

Email your CV and a statement of research interests to me by June 1st, 2019 for consideration. I will conduct in-person, phone, and/or skype interviews beginning in June. 

For PhD students from IDM or PMI interested in a rotation during the 2020-2021 academic year:

Email your CV and a statement of research interests to me as early as possible for consideration. I will conduct in-person, phone, and/or skype interviews as needed.

The Hartman lab is seeking motivated post-doctoral scholars with an interest in the neuropathogenesis of arboviruses. Candidates will need to pass Department of Justice clearance and the University of Pittsburgh’s Tier 1 Select Agent Suitability Assessment.  Successful applicant must be willing to work in BSL-3/ABSL-3 and undergo a rigorous safety training program. Entry-level or experienced post-docs are encouraged to apply. Interested candidates should email a CV and cover letter.  

HartmanLab

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