Presenter: Antonella Marrocco
Paper: Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
Authors: Duco Steven Koenis, Lejla Medzikovic,
Pieter Bas van Loenen, ... , Wilbert Zwart,
Eric Kalkhoven, Carlie Jacoba de Vries
Abstract: Koenis et al. show that nuclear receptor Nur77 regulates the reprogramming of mitochondrial metabolism in inflammatory macrophages. Nur77-deficient macrophages accumulate higher levels of succinate and produce more pro-inflammatory cytokines and nitric oxide in a succinate dehydrogenase-dependent manner. In vivo, bone marrow Nur77 deficiency exacerbates atherosclerosis and increases circulating succinate levels.
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Last Updated On Friday, April 5, 2019 by Orbell, Adam W
Created On Friday, April 5, 2019
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