EOH Events

EOH Departmental Calendar

No events to display
Event

Recent Events

EOH Journal Club

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogram

Thursday 4/11 11:00AM - 12:00PM
4140 Public Health, Young Seminar Room

Presenter: Antonella Marrocco

Paper: Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

Authors: Duco Steven Koenis, Lejla Medzikovic,
Pieter Bas van Loenen, ... , Wilbert Zwart,
Eric Kalkhoven, Carlie Jacoba de Vries

Abstract: Koenis et al. show that nuclear receptor Nur77 regulates the reprogramming of mitochondrial metabolism in inflammatory macrophages. Nur77-deficient macrophages accumulate higher levels of succinate and produce more pro-inflammatory cytokines and nitric oxide in a succinate dehydrogenase-dependent manner. In vivo, bone marrow Nur77 deficiency exacerbates atherosclerosis and increases circulating succinate levels.

Click Here For Article

Last Updated On Friday, April 5, 2019 by Orbell, Adam W
Created On Friday, April 5, 2019

JunJuly 2020Aug
SunMonTueWedThuFriSat
2829301234
567891011
12131415161718
19202122232425
2627282930311
2345678

Submit events and news

Click to enter calendar events or share news and announcements.