Presenter: Antonella Marrocco

Paper: Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

Authors: Duco Steven Koenis, Lejla Medzikovic,
Pieter Bas van Loenen, ... , Wilbert Zwart,
Eric Kalkhoven, Carlie Jacoba de Vries

Abstract: Koenis et al. show that nuclear receptor Nur77 regulates the reprogramming of mitochondrial metabolism in inflammatory macrophages. Nur77-deficient macrophages accumulate higher levels of succinate and produce more pro-inflammatory cytokines and nitric oxide in a succinate dehydrogenase-dependent manner. In vivo, bone marrow Nur77 deficiency exacerbates atherosclerosis and increases circulating succinate levels.

Click Here For Article