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EOH Journal Club - Spring 2017 - Teresa Anguiano

Thursday 4/6 11:00AM - 12:00PM
EOH Journal Club Seminar - Spring 2017

Date: Thursday April 6, 2017

Time: 11am - 12pm

Presenter: Teresa Anguiano

Paper: Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

Authors: Hideyuki Shirasawa, Noboru Matsumura, Masayuki Shimoda, Satoshi Oki, Masaki Yoda, Takahide Tohmonda, Yae Kanai, Morio Matsumoto, Masaya Nakamura & Keisuke Horiuch

Abstract: Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle plasticity and contraction strength. These changes in the mechanical properties of the affected muscle render surgical repair of RCT highly formidable. Therefore, it is important to learn more about the pathology of fatty infiltration to prevent this undesired condition. In the present study, we aimed to generate a mouse model that can reliably recapitulate some of the important characteristics of muscular fatty infiltration after RCT in humans. We found that fatty infiltration can be efficiently induced by a combination of the following procedures: denervation of the suprascapular nerve, transection of the rotator cuff tendon, and resection of the humeral head. Using this model, we found that platelet-derived growth factor receptor-α (PDGFRα)-positive mesenchymal stem cells are induced after this intervention and that inhibition of PDGFR signaling by imatinib treatment can significantly suppress fatty infiltration. Taken together, the present study presents a reliable fatty infiltration mouse model and suggests a key role for PDGFRα-positive mesenchymal stem cells in the process of fatty infiltration after RCT in humans.
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Last Updated On Friday, March 31, 2017 by Orbell, Adam W
Created On Friday, February 24, 2017

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