University of Pittsburgh Directory Calendar News Careers Alumni Giving

Search
  • Home
  • Behavioral and Community Health Sciences
  • Biostatistics
  • Environmental and Occupational Health
    • Academics

      • MPH
      • MS
      • PhD
      • Certificates
      • Courses
        • Class Schedule
    • Research & Practice

      • Centers Overview
      • Faculty Research
        • Faculty Research Interests
      • Student Research
    • Admissions & Aid

      • Admissions
      • Financial Aid
      • Request Information
      • Apply Now
    • Seminars & Events

      • EOH Events
      • EOH and Molecular Toxicology Journal Club
      • EOH Dissertation Defenses
    • Who's Who

      • Faculty (All)
        • Primary Faculty
        • Secondary Faculty
        • Adjunct Faculty
        • Emeritus and Retired Faculty
      • Staff (All)
      • Postdoctoral Researchers
      • Contact Us
    • About

      • Welcome from Chair
      • History
      • Mission
      • Strategic Plan
      • EOH Department News
        • EOH Faculty & Research News
        • EOH Student Stories
        • EOH Alumni Profiles
        • Social Media
      • Alumni
  • Epidemiology
  • Health Policy and Management
  • Human Genetics
  • Infectious Diseases and Microbiology
  • Academics
    • MPH
    • MS
    • PhD
    • Certificates
    • Courses
      • Class Schedule
  • Research & Practice
    • Centers Overview
    • Faculty Research
      • Faculty Research Interests
    • Student Research
  • Admissions & Aid
    • Admissions
    • Financial Aid
    • Request Information
  • Seminars & Events
    • EOH Events
    • EOH and Molecular Toxicology Journal Club
    • EOH Dissertation Defenses
  • Who's Who
    • Faculty (All)
      • Primary Faculty
      • Secondary Faculty
      • Adjunct Faculty
      • Emeritus and Retired Faculty
    • Staff (All)
    • Postdoctoral Researchers
    • Contact Us
  • About
    • Welcome from Chair
    • History
    • Mission
    • Strategic Plan
    • EOH Department News
      • EOH Faculty & Research News
      • EOH Student Stories
      • EOH Alumni Profiles
      • Social Media
    • Alumni
Apply Now

EOH Events

EOH Departmental Calendar

No events to display
Event

Recent Events

EOH Journal Club

EOH Journal Club - Spring 2017 - Chai-Hsin/Aaron Liu

  Email this event to me @

Thursday 3/16 11:00AM - 12:00PM
EOH Journal Club Seminar - Spring 2017

Date: Thursday March 16, 2017

Time: 11am - 12pm

Presenter: Chai-Hsin/Aaron Liu

Paper: Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Authors: Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández-Marcos PJ, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, Santamaría D, Barbacid M.

Abstract:
Patients with advanced Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant lung adenocarcinoma are currently treated with standard chemotherapy because of a lack of efficacious targeted therapies. We reasoned that the identification of mediators of Kras signaling in early mouse lung hyperplasias might bypass the difficulties that are imposed by intratumor heterogeneity in advanced tumors, and that it might unveil relevant therapeutic targets. Transcriptional profiling of Kras(G12V)-driven mouse hyperplasias revealed intertumor diversity with a subset that exhibited an aggressive transcriptional profile analogous to that of advanced human adenocarcinomas. The top-scoring gene in this profile encodes the tyrosine kinase receptor DDR1. The genetic and pharmacological inhibition of DDR1 blocked tumor initiation and tumor progression, respectively. The concomitant inhibition of both DDR1 and Notch signaling induced the regression of KRAS;TP53-mutant patient-derived lung xenografts (PDX) with a therapeutic efficacy that was at least comparable to that of standard chemotherapy. Our data indicate that the combined inhibition of DDR1 and Notch signaling could be an effective targeted therapy for patients with KRAS-mutant lung adenocarcinoma.

Click Here For Article

Enrolled Users:

Last Updated On Friday, January 20, 2017 by Orbell, Adam W
Created On Friday, January 20, 2017

  • Return
  • Export
NovDecember 2019Jan
SunMonTueWedThuFriSat
12345
1 Event(s)
6
1 Event(s)
7
891011121314
15161718192021
22232425262728
2930311234
567891011

View more events at Pitt Public Health

  • FULL SCHOOL CALENDAR
  • LCD screens (scrolling events)
  • The Week Ahead 
  • Grand Rounds
  • Student organization events
  • Food For Thought
  • One Book, One Community
  • Dissertation defenses
  • CPH continuing education
  • Academic calendar
  • Graduation deadlines
  • Professional Development
  • Career Services events and
    Pitt Bridges
  • Governance Meetings
  • Alumni Events

Submit events and news

Click to enter calendar events or share school news and announcements.

Back to Top

Map-Parran Hall, Pittsburgh, PA

Pitt Public Health
130 De Soto Street
Pittsburgh, PA 15261 USA

Contact Us
Prospective Students
What is Public Health?
Why Pitt Public Health?
Academics
Student Life
Admissions

Governance
Delta Omega
Resources
For Employers
Open Positions

Update Your Profile

Technology Support
Technology Policies

Communications Tools
and Samples
CEPH
© 2019 by University of Pittsburgh Graduate School of Public Health

Login  |  Sitemap