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Fri 8/7/2020 1:00PM - 2:00PM
EOH Dissertation Defense
Cody Wolfe - "Trem2 deficiency differentially affects the phenotype ..." EOH Dissertation Defense
Cody Wolfe - "Trem2 deficiency differentially affects the phenotype ..."
Fri 8/7/2020 1:00PM - 2:00PM
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Recent Events

EOH Journal Club

EOH Journal Club - Spring 2017 - Qiao Lin

Thursday 3/2 11:00AM - 12:00PM
EOH Journal Club Seminar - Spring 2017

Date: Thursday March 2, 2017

Time: 11am - 12pm

Presenter: Qiao Lin

Paper: Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

Authors: Lam SJ, O'Brien-Simpson NM, Pantarat N, Sulistio A, Wong EH, Chen YY, Lenzo JC, Holden JA, Blencowe A, Reynolds EC, Qiao GG.

Abstract: With the recent emergence of reports on resistant Gram-negative 'superbugs', infections caused by multidrug-resistant (MDR) Gram-negative bacteria have been named as one of the most urgent global health threats due to the lack of effective and biocompatible drugs. Here, we show that a class of antimicrobial agents, termed 'structurally nanoengineered antimicrobial peptide polymers' (SNAPPs) exhibit sub-μM activity against all Gram-negative bacteria tested, including ESKAPE and colistin-resistant and MDR (CMDR) pathogens, while demonstrating low toxicity. SNAPPs are highly effective in combating CMDR Acinetobacter baumannii infections in vivo, the first example of a synthetic antimicrobial polymer with CMDR Gram-negative pathogen efficacy. Furthermore, we did not observe any resistance acquisition by A. baumannii (including the CMDR strain) to SNAPPs. Comprehensive analyses using a range of microscopy and (bio)assay techniques revealed that the antimicrobial activity of SNAPPs proceeds via a multimodal mechanism of bacterial cell death by outer membrane destabilization, unregulated ion movement across the cytoplasmic membrane and induction of the apoptotic-like death pathway, possibly accounting for why we did not observe resistance to SNAPPs in CMDR bacteria. Overall, SNAPPs show great promise as low-cost and effective antimicrobial agents and may represent a weapon in combating the growing threat of MDR Gram-negative bacteria.

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Last Updated On Friday, January 20, 2017 by Orbell, Adam W
Created On Friday, January 20, 2017

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