Mingyao Li, PhD, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania.
Peter Mueller, PhD, Department of Mathematics, Department of Statistics and Data Sciences, University of Texas at Austin
Lu Mao, PhD, Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison
Snehalata Huzurbazar, PhD, Department of Biostatistics, West Virginia University
Meetings of the Eastern North American Region of the International Biometric Society (a.k.a. "ENAR meetings") are held in late March or early April each year and reflect the broad interests of the Society, including both quantitative techniques and application areas. Faculty and student presenters from the Department of Biostatistics regularly participate giving invited talks, contributed talks, and poster presentations.
The Joint Statistical Meetings, known simply as "JSM", is the largest gathering of statisticians held annually in North American. Faculty and student presenters from the Department of Biostatistics regularly participate giving invited talks, contributed talks, and poster presentations. Our students often receive top awards and participate in the affiliated career marketplace at the event.
Biostatistics guest speaker, Jenna Carlson, University of Pittsburgh, will present, "Population-Specific Reference Panels and Genetic Association Studies in Sāmoans."
Genome-wide association studies (GWAS) in isolated populations like Sāmoans have furthered the understanding of human biology, including the genetic architecture of complex traits. Genetic imputation has become standard practice in GWAS; however, existing imputation panels – the basis on which imputation is performed – are not designed to adequately capture genetic variation in isolated populations. For accurate imputation in these populations, existing imputation reference panels need to be expanded to include haplotypes derived from population-specific whole-genome sequencing (WGS) data. In this talk, I will explain the importance of population-specific reference panels in genotype imputation and describe how I created a Sāmoan-specific reference panel derived from WGS of 1,195 Sāmoans. I will illustrate how we used this reference panel to impute genetic markers genome-wide and conduct association analyses with numerous phenotypes. I will also demonstrate teaching logistic regression to introductory graduate students with a case study from this research: the genetics of obesity in Sāmoans.
Last Updated On Thursday, June 14, 2018 by Kapko, Bernadette E
Created On Thursday, June 14, 2018