Directory Calendar News Careers Alumni Giving

IDM Master's Defenses

IDM Master's Defenses

Upcoming Master's Defenses



No events to display

Recent Master's Topics

IDM Master's Defense

Phil Han "Chemical-Biology Approach to Delineate the Mechanism on Action of HIV-1 Latency ..."

Friday 4/21 9:30AM - 10:30AM
Public Health Auditorium (G23)

"Chemical-Biology Approach to
Delineate the Mechanism on Action of
HIV-1 Latency Reversing Agents"

Abstract:  Prostratin has been applied as a promising latency reversing agent for the eradication of HIV-1 latent CD4+ T cell reservoirs, yet the molecular mechanism of this reactivation remains unclear. Here, we design a novel chemical biology approach revealing that PKC-Mek pathway is essential for prostratin-induced reactivation of latent HIV-1 provirus. First, 7 different Mek inhibitors were identified by the approach that constantly impaired prostratin-induced reactivation. Second, PKC inhibitors, Raf inhibitors, and Erk inhibitors showed different level of inhibition in the latency reversal induced my prostratin. Consistent with this observation, we found that prostratin-induced latency reversal was involved with the kinase activation cascade of PKC-Mek pathway. In addition, we identified several kinase inhibitors that activated HIV-1 latent genes in a significant level individually, including CUDC-101, XMD8-92, PD173074, Quizartinib, and CUDC-907.  Therefore, this chemical biology approach provides new methods of revealing the molecular mechanism of LRAs into the HIV-1 eradication research.


Last Updated On Thursday, April 27, 2017 by Malenka, Judith Ann
Created On Tuesday, April 18, 2017

Questions and Submissions

The schedule of defenses in the Department of Infectious Diseases and Microbiology is maintained by:

Abby Michael
abm82@pitt.edu 
412-624-3331

Share the details for your defense to ensure it is displayed here as well as on the department calendar, Pitt Public Health's calendar, Weekly Update, and LCD screens.

© 2017 by University of Pittsburgh Graduate School of Public Health

Login  |  Sitemap