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Inefficient HIV-1 trans Infection of CD4+ T Cells by Macrophages from HIV-1 Nonprogressors Is Associated with Altered Membrane Cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - DeLucia, Rinaldo, and Rappocciolo show that efficiency of MΦ-mediated HIV trans infection of CD4+ T cells is a unique characteristic associated with control of disease progression, and it is impaired in HIV-infected NP. Their work demonstrates that the use of SIMV to decrease this mechanism of virus transfer should be considered for future HIV therapeutic development.  

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.   

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead.  

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified despite a high number of official dengue notifications in the area during this period. Here they show the important epidemiological features of these cas... 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease.  

New roles for Cauley and Ayyavoo

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JANE CAULEY, who has served as the associate dean for research, will be stepping down from that position to take on additional responsibilities as the executive vice chair of EPI. Cauley is also a distinguished professor of epidemiology. VELPANDI AYYAVOO, currently associate dean for faculty affairs and IDM professor, will become the associate dean for research and faculty affairs. Congratulations!   

The new 2018 Pittsburgh Summer Institute cohort

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The 2018 Pittsburgh Summer Institute (PSI), a collaborative internship program between the Allegheny County Health Department and Pitt Public Health, welcomed 16 students at orientation yesterday. The students will be addressing real-world public health problems and completing a group project about the tobacco retail environment.  

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.   

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM interaction and downstream signaling cascades associated with synaptodendritic functions.   

In Harm’s Way: Women, HIV, Hep C, and Substance Use, hosted by MAAETC

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The MidAtlantic AIDS Education and Training Center hosted a conference that brought together regional experts to explore ways to increase awareness of the opioid and Hepatitis C epidemics affecting women and infants in Southwestern Pennsylvania. One outcome of note: they identified solutions to improve the current care model of clinical and behavioral health care for women of childbearing age who are opioid users.  

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