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Salk's son: Eradication of polio would make Pittsburgh proud

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TRIBLIVE - “The eradication of polio has been tantalizingly close for years now,” said Dean DONALD BURKE.... IDM visiting professor PETER SALK adds, “When polio is ultimately eradicated, it will be something the University of Pittsburgh and Pittsburghers in general can be proud of. The University played a major role in something that will be earthshaking.” Before that milestone is achieved, Jonas Salk's injectable form of the vaccine must be ... 

Ernesto Marques on how the response to Zika failed millions

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NEW YORK TIMES - Infectious disease specialist with IDM and at the Oswaldo Cruz Foundation in Brazil, ERNESTO MARQUES JR. said Brazilian scientists felt let down when they looked for outside help—at first from European donors and health agencies. “The local researchers’ role was mainly to collect samples,” Marques said bitterly.  

The Opioid Epidemic and a Long Overdue Response

Associate Professor Linda Frank takes thoughtful look at responses to opioid epidemic. From our department and Pitt Public Health there can be many actions that can be taken. 

Extensive Brain Defects Seen in Babies of Mothers With Zika

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THE NEW YORK TIMES - … Dr. Ernesto T. A. Marques Jr., an infectious disease specialist at the University of Pittsburgh and the Oswaldo Cruz Foundation in Brazil, said that study was consistent with what he had seen in Recife, Brazil. …  

Microcephaly Found in Babies of Zika-Infected Mothers Months After Birth

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NEW YORK TIMES - Dr. Ernesto T. A. Marques Jr., an infectious disease specialist at the University of Pittsburgh and the Oswaldo Cruz Foundation in Recife, who was not involved in either study, said it could be that because of the initial fetal brain damage, “the necessary pathways and hormones that organize growth of the neonatal brain are not there anymore and the brain doesn’t grow.” 

Meet Joanna Shaw (IDM ’18), Dean’s Scholar

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Unsure of whether to pursue an MD, a PhD, or both, incoming Dean's Scholar JOANNA SHAW chose Pitt Public Health's Department of Infections Diseases and Microbiology to further develop her research and lab skills while she solidifies her research and career plans... 

Rodriguez Serves on Raccoon Oral Rabies Vaccination Team

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As a participant in the Allegheny County Health Department’s Pittsburgh Summer Institute (ACHD PSI), Samantha Rodriguez (IDM '16) helped to plan, execute, and review the county’s Raccoon Oral Rabies Vaccination (ORV) Program, as well as assisted with ORV distribution. 

Lowery conducts West Nile Virus surveillance with ACHD

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Joel Lowery (IDM ’17) assisted the ACHD in conducting its annual surveillance of West Nile Virus (WNV) in order to make informed decisions on vector control related to mosquitoes. In addition to WNV, the team monitored Aedes albopictus , a possible mosquito vector for the Zika virus. Lowery was responsible for setting traps, entering data, and shipping samples to the Pennsylvania Department of Environmental Protection for testing. He took awa... 

There's No Vaccine Yet for CMV

Work on a vaccine for CMV has been going on for many years, said microbiologist Charles Rinaldo, PhD, an expert in cytomegalovirus in the Department of Infectious Diseases and Microbiology at Pitt Public Health. 

Revolutionary Acts: How the discussion of HIV risk matters for the health of Black men who have sex with men

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Derrick D. Matthews, assistant professor in the University of Pittsburgh Graduate School of Public Health’s Department of Infectious Diseases and Microbiology, focuses his research upon the disproportionate burden the HIV epidemic has on black gay, bisexual and other men who have sex with men (MSM) in the U.S....  

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Recent IDM Publications

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells 

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells

NATURE MEDICINE - Gupta, Sanyal, Ratner, Ding, Zerbato, Giacobbi, Venkatachari, Patterson, Chargin, Chen, Mailliard, Rinaldo, and Sluis-Cremer found that the size of the inducible latent HIV-1 reservoir in aviremic subjects on ART is approximately 70-fold larger than previous estimates.  (02/08/2018)

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IDM Videos

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IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO) 

IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO)

UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1998 World AIDS Day, Pitt IDM AIDS researcher Charles Rinaldo and the late Bridget Murtagh of th... (07/17/2018)
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Matthews on why we need a public health approach to HIV (video) 

Matthews on why we need a public health approach to HIV (video)

IDM's DERRICK MATTHEWS explains Pitt Public Health's work on HIV/AIDS and where we are today. "If your’e a black gay man in the U.S., you have a one in two change in your lifetime of becoming HIV positive…short of the cure that we’re looking for, the biology is way ahead of the social implementat... (06/20/2018)
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Matthews discusses the fields of infectious diseases and microbiology (IDM) (video) 

Matthews discusses the fields of infectious diseases and microbiology (IDM) (video)

IDM's DERRICK MATTHEWS demystifies infectious diseases and microbiology with a basic overview of the fields, how they are practiced, and how disease is spread.  (06/19/2018)
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Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO) 

Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO)

Doctoral candidate, DIANA DeLUCIA (IDM '19), presented some of her dissertation research on how the cholesterol levels in immune cells might be impacting HIV infection and disease progression to AIDS. It was found that antigen-presenting cells in nonprogressors have lower cholesterol levels which i... (04/19/2018)
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