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IDM Department News

Care packages received by Peace Corps Volunteers Godfrey and Cook

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INGRID GODFREY (IDM), pictured, and CLAY COOK (BCHS), both Peace Corp Volunteers in Moldova, were delighted to receive the care packages sent by friends via the Center for Global Health. The boxes were filled with cards and small, non-perishable items like candy, magazines, lightweight books, and small personal care items. 

MPH students Cox and Feathers represent the health department at Sci Tech Days

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MPH students ERIN COX (EPI) and ALISON FEATHERS (IDM), along with members of the National Health Corps Pittsburgh, represented the Allegheny County Health Department at the Carnegie Science Center’s annual Sci Tech Days. They presented information about Lyme disease to middle and high school student participants. 

DC alumni reception brings together friends and colleagues

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Dozens of Pitt Public Health grads from the capital area gathered at Penn Social during the 2017 ASPPH annual meeting, joining Dean Burke and host faculty for hearty conversations and refreshments. If the forecast of snow scared you away, we missed you! Access our photo albums anytime at www.publichealth.pitt.edu/flickr. 

IDM's Ernesto Marques knows Brazil's Zika families suffer a life of struggle and scares

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NEW YORK TIMES - In the impoverished northeast, devoted parents live around the needs of children whose grave disabilities are only beginning to be understood. “These babies, most of them or all of them, they’re going to live very long lives, you can keep them alive a long time, and they will need assistance from someone 24 hours a day,” said ERNESTO MARQUES, an infectious disease expert at the University of Pittsburgh and the Oswaldo Cruz Founda... 

IDM's Mellors finds latent HIV may exist in both resting and non-resting CD4 T cells

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INFECTIOUS DISEASE ADVISOR - Work of study co-author and IDM professor JOHN MELLORS reported that different clonal virus populations can be recovered from the two cell types. The findings suggest that inducible virus production may be a good marker of the latent infectious reservoir in both cell types. Identifying the sources of latent HIV and developing tools to measure improvements in therapies are essential for clinicians and their patients. 

Emily Robbins (IDM '16) joins Philadelphia Department of Public Health

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Congratulations to EMILY ROBBINS (IDM '16)  on her new position with the Philadelphia Department of Public Health (PDPH). She will work as an epidemiology program associate in waterborne diseases with an initial primary focus on Legionella prevention within the community.  

Son of Salk: cooperation will end polio

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PITT NEWS - Peter Salk knows the last step to eradicating polio: teamwork.   According to him, his father, Jonas Salk--the inventor of the injected polio vaccine in 1952--knew more than research would be necessary to eradicate the virus: “Cooperation brings us results. But he knew we have to deal with the issues that arise from man’s relationship to man.” Salk spoke to 150 students, professionals, and Pittsburghers about achieving polio eradi... 

Salk's son: Eradication of polio would make Pittsburgh proud

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TRIBLIVE - “The eradication of polio has been tantalizingly close for years now,” said Dean DONALD BURKE.... IDM visiting professor PETER SALK adds, “When polio is ultimately eradicated, it will be something the University of Pittsburgh and Pittsburghers in general can be proud of. The University played a major role in something that will be earthshaking.” Before that milestone is achieved, Jonas Salk's injectable form of the vaccine must be ... 

Ernesto Marques on how the response to Zika failed millions

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NEW YORK TIMES - Infectious disease specialist with IDM and at the Oswaldo Cruz Foundation in Brazil, ERNESTO MARQUES JR. said Brazilian scientists felt let down when they looked for outside help—at first from European donors and health agencies. “The local researchers’ role was mainly to collect samples,” Marques said bitterly.  

The Opioid Epidemic and a Long Overdue Response

Associate Professor Linda Frank takes thoughtful look at responses to opioid epidemic. From our department and Pitt Public Health there can be many actions that can be taken. 

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Recent IDM Publications

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells 

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells

NATURE MEDICINE - Gupta, Sanyal, Ratner, Ding, Zerbato, Giacobbi, Venkatachari, Patterson, Chargin, Chen, Mailliard, Rinaldo, and Sluis-Cremer found that the size of the inducible latent HIV-1 reservoir in aviremic subjects on ART is approximately 70-fold larger than previous estimates.  (02/08/2018)

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IDM Videos

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IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO) 

IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO)

UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1998 World AIDS Day, Pitt IDM AIDS researcher Charles Rinaldo and the late Bridget Murtagh of th... (07/17/2018)
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Matthews on why we need a public health approach to HIV (video) 

Matthews on why we need a public health approach to HIV (video)

IDM's DERRICK MATTHEWS explains Pitt Public Health's work on HIV/AIDS and where we are today. "If your’e a black gay man in the U.S., you have a one in two change in your lifetime of becoming HIV positive…short of the cure that we’re looking for, the biology is way ahead of the social implementat... (06/20/2018)
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Matthews discusses the fields of infectious diseases and microbiology (IDM) (video) 

Matthews discusses the fields of infectious diseases and microbiology (IDM) (video)

IDM's DERRICK MATTHEWS demystifies infectious diseases and microbiology with a basic overview of the fields, how they are practiced, and how disease is spread.  (06/19/2018)
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Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO) 

Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO)

Doctoral candidate, DIANA DeLUCIA (IDM '19), presented some of her dissertation research on how the cholesterol levels in immune cells might be impacting HIV infection and disease progression to AIDS. It was found that antigen-presenting cells in nonprogressors have lower cholesterol levels which i... (04/19/2018)
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