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IDM students and faculty participate in March for Science

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IDM students and faculty were among the thousands to participate in March for Science events held on April, 22, 2017 in Oakland (adjacent to the Pitt campus) and in Washington, DC. These nonpartisan event sought to celebrate the role that science plays in our everyday lives. 

Marques offers insignt as Zika season approaches

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TRIB LIVE - In the U.S., there have been 5,264 Zika cases reported, with the vast majority in travelers returning from affected areas in other countries, says ERNESTO MARQUES, associate professor with Pitt Public Health and scientific director of CURA ZIKA, an international alliance with counterparts in Brazil to help fundraising for research into the virus. Learn more about Cura Zika at www.publichealth.pitt.edu/curazika. 

Marques looks for clues to Zika damage in twins

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NEW YORK TIMES - Determining why one twin becomes infected in the womb while the other does not may illuminate how Zika crosses the placenta, how it enters the brain, and whether any genetic mutations make a fetus more resistant or susceptible to Zika infection. Perhaps the virus entered through a weak spot in one placenta’s membrane, said ERNESTO MARQUES, an infectious disease expert at Pitt Public Health and the Oswaldo Cruz Foundation in Recif... 

2017 IDM grad Noah Salama heading to Rochester for MD/PhD

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Congratulations to NOAH SALAMA (IDM '17) on his recent acceptance into University of Rochester's 8-year MD/PhD program. As a Pitt MS student, Salama worked with Dr. Amy Hartman on research into viral immune response. His thesis was entitled "Analysis of Peripheral Immune Responses for the Development of an NHP Animal Model for Encephalitic Alphaviruses EEEV, VEEV, and WEEV." 

Study by IDM's Mellors provides new understanding of HIV infections

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A new study represents an important advance toward better treatments and even a cure. “The immune system stays activated, angry, upset and inflamed despite current treatments, and that’s not good,” said study leader JOHN MELLORS of infectious diseases and microbiology. The research, involving various research centers including the National Institute of Allergy and Infectious Diseases, counters the idea “that inflammation and immune-cell activati... 

Care packages received by Peace Corps Volunteers Godfrey and Cook

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INGRID GODFREY (IDM), pictured, and CLAY COOK (BCHS), both Peace Corp Volunteers in Moldova, were delighted to receive the care packages sent by friends via the Center for Global Health. The boxes were filled with cards and small, non-perishable items like candy, magazines, lightweight books, and small personal care items. 

Jennifer Silva, Expert on challenges of coal country to lecture at Pitt Public Health

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PITTSBURGH TRIBUNE-REVIEW - On Tuesday, Jennifer Silva, an assistant professor of sociology at Bucknell University, will share her research tales at Pitt Public Health's “One Book, One Community” lecture. Among the questions Silva is trying to answer in her research: What happens when people feel left behind? Who do they blame? And if they can't rely on getting a job to have a good life, how do they create a life that is meaningful? 

MPH students Cox and Feathers represent the health department at Sci Tech Days

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MPH students ERIN COX (EPI) and ALISON FEATHERS (IDM), along with members of the National Health Corps Pittsburgh, represented the Allegheny County Health Department at the Carnegie Science Center’s annual Sci Tech Days. They presented information about Lyme disease to middle and high school student participants. 

DC alumni reception brings together friends and colleagues

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Dozens of Pitt Public Health grads from the capital area gathered at Penn Social during the 2017 ASPPH annual meeting, joining Dean Burke and host faculty for hearty conversations and refreshments. If the forecast of snow scared you away, we missed you! Access our photo albums anytime at www.publichealth.pitt.edu/flickr. 

IDM's Ernesto Marques knows Brazil's Zika families suffer a life of struggle and scares

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NEW YORK TIMES - In the impoverished northeast, devoted parents live around the needs of children whose grave disabilities are only beginning to be understood. “These babies, most of them or all of them, they’re going to live very long lives, you can keep them alive a long time, and they will need assistance from someone 24 hours a day,” said ERNESTO MARQUES, an infectious disease expert at the University of Pittsburgh and the Oswaldo Cruz Founda... 

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Recent IDM Publications

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells 

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells

NATURE MEDICINE - Gupta, Sanyal, Ratner, Ding, Zerbato, Giacobbi, Venkatachari, Patterson, Chargin, Chen, Mailliard, Rinaldo, and Sluis-Cremer found that the size of the inducible latent HIV-1 reservoir in aviremic subjects on ART is approximately 70-fold larger than previous estimates.  (02/08/2018)

Peripheral blood biomarkers of disease outcome in a monkey model of rift valley fever encephalitis.  

Peripheral blood biomarkers of disease outcome in a monkey model of rift valley fever encephalitis.

JOURNAL OF VIROLOGY - Wonderlich, Caroline, McMillen, Walters, Reed, Barratt-Boyes, and Hartman conclude that African green monkeys are a novel and suitable model for studying the neuropathogenesis of Rift Valley Fever (RVF) and for testing vaccines and therapeutics against this important emerging ... (02/05/2018)

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