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Lancaster and Ma receive Owen's Fellowship

ASHLYN LANCASTER and HENRY MA, both IDM students, received the Owen's Fellowship from the University. A bequest of Samuel T. Owens Jr. makes fellowships available for students who show promise of high academic achievement.    

As Zika babies become toddlers, some can’t see, walk, or talk

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NEW YORK TIMES - Infectious disease researcher ERNESTO MARQUES says about 3 percent of 1,000 pregnant Brazilian women in a recent sample were infected with Zika. “The problem’s not going away. We are still having cases. And the future of Zika babies already born is complicated by poverty and strained resources. “Most of these babies are from low socioeconomic status and rely on the public health system to provide care. It’s very difficult to mana... 

Mailliard presents research on improving HIV “kick and kill” strategies to IAS Conference on HIV Science in Paris (Video)

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YOUTUBE - IDM's Mailliard presents his research on “kick and kill” strategies at the 9th IAS Conference on HIV Science, the world's largest open scientific conference on HIV and AIDS-related issues. The work demonstrates that naïve T cells have the ability to effectively target the HIV-1 reservoir, highlighting the importance of directing HIV-1 curative strategies towards the induction of de novo rather than memory HIV-1-specific CTL responses.  

Stall’s research helps to “Kick ASS”

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SAN FRANCISCO BAY TIMES - The reality of AIDS Survivor Syndrome (ASS) is now being confirmed by empirical research. On November 3, 2017, BCHS Associate Chair for Science RON STALL presented his findings on the subject in San Francisco at a provider and community town hall entitled “Research on the AIDS Survivor Syndrome: New Data from The Multi-Center AIDS Cohort Study and Voices of Survivors Themselves.” 

Marques: While Zika hasn’t been in the news much, that doesn’t mean it’s gone

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WASHINGTON POST - Local transmission seems to have come to a standstill, with one suspected case in Texas and one case confirmed in Florida. Herd immunity may be preventing more big outbreaks. But if Zika behaves like other arboviruses, it will probably stick around. They tend to be cyclical, says Pitt Public Health researcher ERNESTO MARQUES. “You have big booms, then they drop. Then a few years later, they come back again.” 

Enigma: Marques worked to pinpoint culprit of mysterious illness in Brazil

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PITTWIRE - When a mysterious illness suddenly emerged in his Brazilian hometown, IDM researcher ERNESTO MARQUES mobilized with colleagues to decode its unknowns. The work may help infectious-disease researchers stop or stall new epidemics. His story begins on page 18. 

Acceptance Journeys Pittsburgh — Pop-up photo exhibit in Harrisburg

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ACCEPTANCE JOURNEYS PITTSBURGH is a Pitt Public Health photo-story project where community members share stories of love and acceptance for their lesbian, gay, bisexual, and transgender (LGBT) friends and family. The Pennsylvania Department of Health invited us to host a pop-up exhibit on Wednesday, October 18, 2017, as part of the commonwealth’s LGBTQ History month activities. The display was in Strawberry Square in downtown Harrisburg  

Award-winning posters recognized at annual IDM Research Day

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This September, the Department of Infectious Diseases and Microbiology recognized student research poster winners at the annual IDM research day.  Students winners were awarded prizes in various categories during the next day's IDM annual meeting and picnic at North Park.   

Schleupner, IDM alumnus, appointed to Virginia Tech Carilion School of Medicine Dean's Council on Advancement

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Congratulations to alumnus CHARLES JOHN SCHLEUPNER (IDM ’68), who has been appointed to the Dean’s Council on Advancement for the Virginia Tech Carilion School of Medicine. The council is a committee of volunteers created to advance the stature of the medical school by providing guidance, assistance, advocacy, and philanthropic investment in support of the school’s strategic objectives. 

Discussing the legacy of polio, one of the most dreaded disease in history (VIDEO)

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KD/PG SUNDAY EDITION - KDKA’s Stacy Smith and the Post-Gazette’s Jerry Micco discuss present-day challenges in the worldwide fight to eradicate polio with PETER SALK, visiting professor  in IDM, as well as his childhood growing up in Pittsburgh while his father's team developed the first injectable polio vaccine in the 1950s. 

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Recent IDM Publications

Development of antibody biomarkers of long term and recent dengue virus infections 

Development of antibody biomarkers of long term and recent dengue virus infections

JOURNAL OF VIROLOGICAL METHODS - BURKE, MARQUES, and colleagues discuss anti-dengue NS1-specific IgG and IgG3 as potential biomarkers of long-term and recent (less than 6 months) DENV infections, respectively.  (06/14/2018)

Tradition and innovation in development of a Zika vaccine 

Tradition and innovation in development of a Zika vaccine

THE LANCET - MARQUES and BURKE comment about two Zika vaccines in clinical development and describe the challenges ahead. (06/14/2018)

Zika virus displacement by a chikungunya outbreak in Recife, Brazil 

Zika virus displacement by a chikungunya outbreak in Recife, Brazil

PUBLIC LIBRARY OF SCIENCE - Magalhaes, Braga, Cordeiro, Oliveira, Castanha, Maciel, Amancio, Gouveia, Peixoto-deSilva Jr., Peixoto, Britto, Lima, Lima, and Marques detected the tail end of a Zika epidemic in 2015-16 which was displaced by a chikungunya epidemic. Few dengue cases were identified des... (06/14/2018)

Rift Valley fever in animals and humans: Current perspectives 

Rift Valley fever in animals and humans: Current perspectives

ANTIVIRAL RESEARCH - McMillen and Hartman discuss the historical role of Rift Valley Fever (RVF) as a biological weapon and conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease. (06/11/2018)

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN 

Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN

JOURNAL OF VIROLOGY - Delucia, Rinaldo, Rappocciolo demonstrate that the use of SIMV to decrease macrophage-mediated virus transfer should be considered for future HIV therapeutic development.  (05/18/2018)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury 

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysredulates neurogranin and induces synaptodendritic injury

JOURNAL OF NEUROINFLAMMATION - Guha, Wagner, Ayyavoo conduct first study evaluating the potential role of Ng in the context of HIV-1 neropathogens and conclude that synaptic damage in HAND+ patients could be a result of abrogation of Ng through HIV-1 induced inflammation that dysregulates Ng-CaM in... (05/18/2018)

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques 

Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques

JOURNAL OF IMMUNOLOGY - Wonderlich, Swan, Bissel, Hartman, Carney, O'Malley, Obadan, Santos, Walker, Sturgeon, Frye, Maiello, Scanga, Bowling, Duangkhae, Wiley, Flynn, Wang, Cole, Reed, Barratt-Boyes establish a new nonhuman primate disease model for evaluation of vaccine and therapeutic approaches... (02/14/2018)

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells 

Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cells

NATURE MEDICINE - Gupta, Sanyal, Ratner, Ding, Zerbato, Giacobbi, Venkatachari, Patterson, Chargin, Chen, Mailliard, Rinaldo, and Sluis-Cremer found that the size of the inducible latent HIV-1 reservoir in aviremic subjects on ART is approximately 70-fold larger than previous estimates.  (02/08/2018)

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IDM Videos

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IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO) 

IDM’s Rinaldo discusses HIV wonder drugs and curing HIV in 1998 World AIDS Day interview (VIDEO)

UPMC HEALTH NEWS – In the late 1990s, new and highly potent anti-HIV drugs emerged— including protease and reverse transcriptase inhibitors—which could for the first time control HIV infection. For this 1998 World AIDS Day, Pitt IDM AIDS researcher Charles Rinaldo and the late Bridget Murtagh of th... (07/17/2018)
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Matthews on why we need a public health approach to HIV (video) 

Matthews on why we need a public health approach to HIV (video)

IDM's DERRICK MATTHEWS explains Pitt Public Health's work on HIV/AIDS and where we are today. "If your’e a black gay man in the U.S., you have a one in two change in your lifetime of becoming HIV positive…short of the cure that we’re looking for, the biology is way ahead of the social implementat... (06/20/2018)
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Matthews discusses the fields of infectious diseases and microbiology (IDM) (video) 

Matthews discusses the fields of infectious diseases and microbiology (IDM) (video)

IDM's DERRICK MATTHEWS demystifies infectious diseases and microbiology with a basic overview of the fields, how they are practiced, and how disease is spread.  (06/19/2018)
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Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO) 

Celebrate 70: DeLucia presents cholesterol regulation of HIV-1 trans infection and HIV-1 disease progression (VIDEO)

Doctoral candidate, DIANA DeLUCIA (IDM '19), presented some of her dissertation research on how the cholesterol levels in immune cells might be impacting HIV infection and disease progression to AIDS. It was found that antigen-presenting cells in nonprogressors have lower cholesterol levels which i... (04/19/2018)
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