A geospatial perspective, for example, analyses of geographic patterns, spatial clustering and relatedness, and the role of proximity or distance, provides opportunities for new insights in many domains. Dr. Stewart will discuss geospatial approaches used to reveal geographic patterns of drug poisoning deaths involving heroin and other illicit drugs (e.g., synthetic opioids and cocaine) in the United States. This analysis has focused on revealing the locations of hotspots of drug poisoning deaths and tracking the evolution of these hotspots over space and time and understanding spatial relationships that may play a key role for researchers interested in drug surveillance. The geographic variation of impacts and the burden on different population groups is important for developing strategies and policies regarding substance use and misuse interventions. Further context is provided through an analysis of spatial accessibility to substance use disorder treatment facilities.