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Robbie B. Mailliard, , PhD

Assistant Professor, Infectious Diseases and Microbiology

Director of the MS Program, Infectious Diseases and Microbiology

Contact

2129 Public Heealth, 130 DeSoto Street, Pittsburgh, PA 15261
R-znvy: eoz64@cvgg.rqh
Primary Phone: 967-179-8393

Assistant(s): 
Holly Bilben, ubo6@cvgg.rqh, 967-838-2945
Kathleen Kulka, xhyxn@cvgg.rqh, 967-179-2070

Personal Statement

Dr. Mailliard's research focuses on the central role played by dendritic cells (DCs) in the induction and regulation of the immune response. In particular, he is interested in the modulation of DC function for the purpose of developing  effective cellular based immunotherapies to treat chronic diseases such as cancer and HIV. His work has led to the development of the so-called "alpha-DC1,"  a  type-1 polarized dendritic cell-based vaccine platform currently being explored in clinical trials for the treatment of cancers and HIV.  Also of interest to Dr. Mailliard are the non-classical “helper” functions of NK cells and CD8+ T cells (CTLs), and their influence on DC function during infection. Currently, he is exploring DC-based methods to prime naïve T cells against autologous HIV-1 in patients receiving anti-retroviral therapy as a 'CURE' strategy. Dr Mailliard is also the Director of the MS program of IDM, and the Co-Director of the University of Pittsburgh HIV Immunology Technologies (HITs) Laboratory that provides immunology laboratory services for the Multicenter AIDS Cohort Study (MACS) and the AIDS Clinical Trials Group (ACTG).


Education

1990  University of Pittsburgh, BS., (Microbiology)
2006   University of Amsterdam, PhD., (Immunology/Medicine) 


Teaching

  • IDM 2003- Host Response to Microbial Infection (Co-Director, Lecturer)
  • IDM 3440- Vaccines and Immunity (Co-Director, Lecturer)
  • IDM 2023- Microbiology Laboratory (Lecturer)
  • IDM2002- Molecular Virology (Lecturer) 


Selected Publications

1. Mailliard RB, Egawa S, Cai Q, Kalinska A, Bykovskaya SN, Lotze MT, Kapsenberg ML, Storkus WJ, Kalinski P. Complementary dendritic cell-activating function of CD8+ and CD4+ T cells: helper role of CD8+ T cells in the development of T helper type 1 responses. J Exp Med. 2002 Feb 18; 195(4):473-83. PMCID: 11854360


2.  Mailliard RB, Son Y, Redlinger R, Coates PT, Giermasz A, Morel PA, Storkus WJ, and Kalinski P,
Dendritic cells mediate NK cell help for Th1 and CTL responses: Two-signal requirement for the induction of NK cell helper function. J Immunol. 2003 Sept; 171(5): 2366-73. PMCID: 12928383

3.  Mailliard RB, Wankowicz-Kalinska A, Cai Q, Amy Wesa, Catherien M. Hilkens, Martien L. Kapsenberg, Kirkwood JM, Storkus WJ, and Kalinski P. Alpha-type-1 Polarized Dendritic Cells (aDC1): A Novel Immunization Tool with Optimized CTL-inducing Activity. Cancer Research. 2004 Sept;64(17):5934. PMCID: 15342370

4.  Kalinski P, Giermasz A, Nakamura Y, Basse P, Storkus WJ, Kirkwood JM, and Mailliard RB. Helper Role of NK Cells during the Induction of Anticancer Immunity by Dendritic Cells. Mol Immunol. 2005, Feb;42(4):535-9. PMCID: 15607810. 

5.  Mailliard RB, Alber SM, Shen H, Watkins SC, Kirkwood JM, Herberman RB, and Kalinksi P. IL-18 induced CD83+CCR7+ NK Helper Cells. J.Exp.Med. 2005 Oct ; 202: 941-953. PMCID: 2213172.

6.  López-Albaitero A, Mailliard RB, Hackman T, Filho PA., Wang X, Gooding W, Ferrone S, Kalinski P and Ferris RL. Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and crosspresenting function. J Immunotherapy Jun 2009;32(5):465-73. PMCID: 19609238

7. Helfer BM, Nelson AD, Ahrens ET, Janjic JM, Gil RR, Kalinski P, de Vries J, Mailliard RB. Functional assessment of human dendritic cells labeled for in vivo 19F MRI cell tracking Cytotherapy. 2010 Jan 7. PMCID: 20053146. 

8.  Mailliard RB, Smith KN, Fecek RJ , Rappocciolo G, Eduardo JM. Nascimento*, Marques ET, Watkins SC, Mullins JI, Rinaldo CR,. Selective induction of CTL “helper” rather than killer activity by natural epitope variants promotes DC-mediated HIV-1 dissemination. J Immunology 2013 191 (5), 2570-2580

9. Wong JL, Mailliard RB, Moschos SJ, Edington H, Lotze MT, Kirkwood JM, Kalinski P.Helper activity of natural killer cells during the dendritic cell-mediated induction of melanoma-specific cytotoxic T cells. Journal of Immunotherapy (Hagerstown, Md.: 1997). 2011 Apr; 34 (3):270-8. PMCID: PMC3057371. PMID: 21389871.

10. Rohatgi S, Gohil S, Kuniholm MH, Schultz H, Dufaud C, Armour KL, Badri S, Mailliard RB, Pirofski LA. Fc Gamma Receptor 3A Polymorphism and Risk for HIV-Associated Cryptococcal Disease. mBio. 2013; 4 (5). PMID: 23982074.

11.  Kellie SN, Mailliard RB, Larsen BB, Wong K, Gupta P, Rinaldo CR. Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1. Journal of Virology. 2014 Sep 1; 88 (17):9976-90. PMID: 24942586.

12.  Zaccard CR, Watkins SC,Kalinski P, Fecek RJ, Yates AL, Salter RD, Ayyavoo V, Rinaldo CR, Mailliard RB. CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity. Journal of Immunology. 2015 Feb 1; 194 (3):1047-56. PMID: 25548234.

13. Smith KN, Mailliard RB, Piazza P, Fischer W, Kerber BT, Fecek RJ, Ratner D, Gupta P, Mullins JI, Rinaldo CR, Effective cytotoxic T lymphocyte targeting of persistent HIV-1 during antiretroviral therapy requires priming of naïve CD8+ T cells. mBio, 2016 May 31;7(3). 2016 May, PMID 27247230

14. Sanyal A, Mailliard RB, Rinaldo CR, Ratner D, Ding M, Chen Y, Zerbato JM, Giacobbi NS, Venkatachari NJ, Patterson BK, Chargin A, Sluis-Cremer N, Gupta P. Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4+ T cells. Nat Med. 2017 Jul;23(7):885-889. PMID: 28553933

Google Scholar page
http://scholar.google.com/citations?user=Y9SfH0UAAAAJ&hl=en


Robbie B.  Mailliard
© 2018 by University of Pittsburgh Graduate School of Public Health

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