Professor, Infectious Diseases and Microbiology
818 Scaife Hall, 200 Lothrop Street, Pittsburgh, PA 15261
Primary Phone: 967-179-3067
HIV/AIDS, new antiretrovirals, HIV drug resistance, antiretroviral therapy, HIV reservoirs and their elimination
Dr. Mellors is a tenured Professor of Medicine (primary) and Infectious Diseases and Microbiology (secondary). He is Chief of Infectious Diseases at the University of Pittsburgh, Principal Investigator of the NIH-funded Pittsburgh AIDS Clinical Trials Unit, and Director of the Virology Core Laboratories for the AIDS Clinical Trials Group and the Microbicide Trials Network, two global HIV research networks.
Dr. Mellors’ research is dedicated to preventing, treating and seeking a cure for HIV infection. His work on the Multicenter AIDS Cohort Study provided critical insight into the relation between viremia and HIV disease progression. His research team also played a key role in developing the first long-term effective antiretroviral therapy. His laboratory has focused on HIV resistance to antiretroviral drugs, which is a major obstacle to effective therapy. His laboratory’s work in this area has helped define the genetic and biochemical basis for HIV resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors of HIV-1 reverse transcriptase, and the clinical impact of such resistance. More recent research projects are focusing on preventiing HIV-1 infection through the use of antiretrovirals and quantifying HIV reservoirs in patients on antiretroviral therapy with the long-term goal of eliminating them.
His laboratory consists of 2-3 doctoral students (IDM and MVM), 4-5 research specialists, 1 medical student, and 2 postdoctoral fellows.
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