Hong Wang, PhD

Research Assistant Professor, Biostatistics


Sterling Plaza, Suite 325, 201 N. Craig St, Pittsburgh, PA 15213
R-znvy: ubj3@cvgg.rqh
Primary Phone: 967-838-6033

Personal Statement

Primary areas of research interest are design and statistical analysis of pre-clinical studies and phase I/II clinical trials, and frailty models in survival analysis. Other areas of interest include in vitro and in vivo radiation survival analysis.


1988, Peking University, Peking, China, BS of Probability and Statistics
1994, Peking University, Peking, China, MS of Probability and Statistics
2004, Medical College of Wisconsin, Milwaukee, WI, PhD of Biostatistics

Selected Publications

1: Willis J, Epperly MW, Fisher R, Zhang X, Shields D, Hou W, Wang H, Li S, Wipf P, Parmar K, Guinan E, Steinman J, Greenberger JS. Amelioration of Head and NeckRadiation-Induced Mucositis and Distant Marrow Suppression in Fanca(-/-) and Fancg(-/-) Mice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiat Res. 2018 Jun;189(6):560-578. doi: 10.1667/RR14878.1. Epub 2018 Mar 27. PubMed PMID: 29584588.

 2: Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res. 2018 Jan;189(1):68-83. doi:10.1667/RR14787.1. Epub 2017 Nov 15. PubMed PMID: 29140165; PubMed Central PMCID: MC5808408.

3. Maxwell JH, Rath TJ, Byrd JK, Albergotti WG, Wang H, Duvvuri U, Kim S, Johnson JT, Branstetter BF 4th, Ferris RL. Accuracy of computed tomography to predict extracapsular spread in p16-positive squamous cell carcinoma. The Laryngoscope. 2015 May 6. PMID:25946149. doi: 10.1002/lary.25140.

4. Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sander C, Kirkwood JM, Chen TH, Maurer M, Korman AJ, Zarour HM. TIGIT and PD-1 impair tumor antigen-specific CD8+ T cells in melanoma patients. The Journal of Clinical Investigation. 2015 May 1; 125 (5):2046-58. PMID: 25866972. doi: 10.1172/JCI80445.

5. Glowacki  J, Mizuno S, Kung J, Goff J, Epperly M, Dixon T, Wang H, Greenberger JS. Effects of Mouse Genotype on Bone Wound Healing and Irradiation-induced Delay of Healing. In Vivo. 2014 Mar; 28 (2):189-96. PMID: 24632972. 

6. Fourcade J, Sun Z, Pagliano O, Chauvin J, Sander C, Janjic B, Tarhini A, Tawbi HA, Kirkwood J, Moschos S, Wang H, Guillaume P, Luescher I, Krieg A, Anderson A, Kuchroo V, Zarour H. PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen-specific CD8¿ T Cells Induced by Melanoma Vaccines. Cancer Research. 2014 Feb; 74 (4):1045-55. PMCID: 3952491. PMID: 24343228. 

7. Kalash R, Berhane H, Yang Y, Epperly M, Wang H, Dixon T, Rhieu B, Greenberger JS, Hug M. Improved Survival of Mice After Total Body Irradiation with 10 MV Photon, 2400 MU/min SRS Beam. In Vivo. 2014 Jan; 28 (1):1-12. PMID: 24425830.

8. Berhane H, Epperly M, Goff J, Kalash R, Cao S, Franicola D, Zhang X, Shields D, Houghton F, Wang H, Wipf P, Parmar K, Greenberger J. Radiologic Differences Between Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines from Fanconi Anemia (Fancd2(-/-)) Mice. Radiation Research. 2014 Jan; 181 (1):76-89. PMCID: 3970166. PMID: 24397476. 

9. Horn CC, Wang H, Estival L, Meyers K, Magnusson MS. Novel dynamic measures of emetic behavior in musk shrews. Autonomic Neuroscience : Basic & Clinical. 2013 Dec; 179:60-7. PMCID: PMC3844068. PMID: 23953843.

10. Goff JP, Shields DS, Wang H, Skoda EM, Sprachman MM, Wipf P, Garapati VK, Atkinson J, London B, Lazo JS, Kagan V, Epperly MW, Greenberger JS. Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Experimental Hematology. 2013 Nov; 41 (11):957-66. PMCID: PMC3834150. PMID:

11. Kalash  R, Epperly M, Goff J, Dixon T, Sprachman M, Zhang X, Shields D, Cao S, Franicola D, Wipf P, Berhane H, Wang H, Au J, Greenberger J. Amelioration of Radiation-induced Pulmonary Fibrosis by a Water-soluble Bifunctional Sulfoxide Radiation Mitigator (MMS350). Radiation Research. 2013 Nov; 180 (5):474-90. PMCID: 3894523. PMID: 24125487.

12. Berhane H, Epperly M, Cao S, Goff J, Franicola D, Wang H, Greenberger J. Radioresistance of Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines Derived from Nrf2-/- Homozygous Deletion Recombinant-Negative Mice. In Vivo. 2013 Sep; 27 (5):571-82. PMID: 23988890.

13. Epperly M, Chaillet JR, Kalash R, Shaffer B, Goff J, Franicola D, Zhang X, Dixon T, Houghton F, Wang H, Berhane H, Romero C, Kim J, Greenberger J. Conditional Radioresistance of Tet-inducible Manganese Superoxide Dismutase Bone Marrow Stromal Cell Lines. Radiation Research. 2013 Aug; 180 (2):189-204. PMCID: 3783950. PMID: 23862693.

14. Epperly M, Berhane H, Cao S, Shields D, Francola D, Goff J, Zhang X, Wang H, Friedlander R, Greenberger J. Increased Longevity of Hematopoiesis in Continuous Marrow Cultures and Radiation Resistance of Marrow Stromal and Hematopoietic Progenitor Cells from Caspase-1 Homozygous Recombinant-negative (knockout) Mice. In Vivo. 2013 Jul; 27 (4):419-30. PMCID: 3775015. PMID: 23812211.

15. Qiu W, Liu H, Sebastini A, Sun Q, Wang H, Zhang L, Yu J. An Apoptosis-independent Role of SMAC in Tumor Suppression. Oncogene. 2013 May 9; 32 (19):2380-9. PMCID: 3751796. PMID: 22751125. 

16. Horn C, Kimball B, Wang H, Kaus J, Dienel S, Nagy A, Gathright G, Yates BJ, Andrews PL. Why Can’t Rodents Vomit? A Comparative Behavioral, Anatomical, and Physiological Study. PLoS One. 2013 Apr 8; 8 (4)::e60537. PMCID: 3622671. PMID: 23593236.

17. Kalash R, Berhane H, Goff J, Houghton F, Epperly MW, Dixon T, Zhang X, Sprachman MM, Wipf P, Franicola D, Wang H, Greenberger JS. Effects of Thoracic Irradiation on Pulmonary Endothelial Compared to Alveolar Type-II Cells in Fibrosis-Prone C57BL/6NTac Mice. In Vivo. 2013; 27 (3):291-7. PMCID: 3783952. PMID: 23606683.

18. Wang H, Klein J. Semiparametric estimation for the additive inverse Gaussian frailty model. Communications in Statistics - Theory and Methods. 2012; 41 (12):2269-2278.

Hong  Wang