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Dr. Ernesto T. A. Marques, Jr., MD/PhD

Associate Professor, Infectious Diseases and Microbiology

Public Health Researcher, FIOCRUZ

Contact

9022 BST3, 3501 Fifth Avenue, Pittsburgh, PA 15260
R-znvy: znedhrf@cvgg.rqh
Primary Phone: 967-193-7507
Secondary Phone: 998-054-8577


Personal Statement

Keywords: Vaccinology, Immunomics,  Molecular mechanisms of dengue immunity and pathogenicity

Research Summary. The research interest of Dr. Marques is designing novel vaccine strategies, immunotherapies, diagnostic markers and disease surveillance tools based on  human samples from well characterized cohorts. The strategy he uses is based on the development of detailed T and B cell epitopes maps and the characterization of innate immune response induced by the pathogenic agents. The laboratory apply a combination of computational technologies, high throughput immune assays in human samples and suitable human transgenic animal models. Using this information we explore patterns correlated either with immunity or pathogenicity and design novel antigen formulations containing selected epitopes, adjuvants and adequate delivery methods. Currently we are applying this strategy to study Dengue, yellow fever, HIV among other agents.


Education

1993 | Federal University of Pernambuco, Recife, Brazil | Medical Doctor - MD
1999 | The Johns Hopkins University School of Medicine  | Doctor of Philosophy - PhD


Teaching

IDM - 2003 - Host Response to Microbial Infection - Course Coordinator
IDM - 2010 - Biology of Pathogens - Lecturer
IDM - 2014 - Functional Genomics of Microbial Pathogens - Lecturer
IDM - 2038 - Prevention, Treatment, and Control of Global Infectious Diseases- Lecturer




Selected Publications

1. Adibi JJ, Marques ET, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet. 2016;387(10027):1587-90. doi: 10.1016/S0140-6736(16)00650-4. PubMed PMID: 26952548.

2. Arruda LB, Sim D, Chikhlikar PR, Maciel Jr. M, Akasaki K, August JT, Marques ETA. Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 Gag chimeras have distinct cellular trafficking pathways and prime T and B cell responses to a diverse repertoire of epitopes. Journal of Immunology. 2006;177(4):2265-75. PubMed PMID: WOS:000239745300034.

3. Braga C, Luna CF, Martelli CMT, Souza WVD, Cordeiro MT, Alexander N, Albuquerque MDFPMD, Junior JCS, Marques ET. Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife, Brazil. Acta Tropica. 2010;113(3):234-40. doi:10.1016/j.actatropica.2009.10.021.PubMed PMID:WOS:000275677700005.

4. Castanha PM, Braga C, Cordeiro MT, Souza AI, Silva CD, Martelli CT, van Panhuis WG, Nascimento EJ, Marques ET. Placental transfer of dengue-specific antibodies and kinetics of dengue infection enhancing-activity in Brazilian infants. J Infect Dis. 2016. doi: 10.1093/infdis/jiw143. PubMed PMID: 27056951.

5. Cordeiro MT, Pena LJ, Brito CA, Gil LH, Marques ET. Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil. Lancet. 2016. doi: 10.1016/S0140-6736(16)30253-7. PubMed PMID: 27103126.

6. Cordeiro MT, Silva AM, Brito CAA, Nascimento EJM, Magalhaes MCF, Guimaraes GF, Lucena-Silva N, Freese De Carvalho EM, Marques Jr. ETA. Characterization of a dengue patient cohort in Recife, Brazil. American Journal of Tropical Medicine and Hygiene. 2007;77(6):1128-34. PubMed PMID: WOS:000252123200026.

7. Hazin AN, Poretti A, Cruz DD, Tenorio M, van der Linden A, Pena LJ, Brito C, Gil LH, Miranda-Filho DB, Marques ET, Martelli CM, Alves JG, Huisman TA, Group MER. Computed Tomographic Findings in Microcephaly Associated with Zika Virus. N Engl J Med. 2016. doi: 10.1056/NEJMc1603617. PubMed PMID: 27050112.

8. Homma A, Tanuri A, Duarte AJS, Marques E, de Almeida A, Martins R, Silva-Junior JB, Possas C. Vaccine research, development, and innovation in Brazil: A translational science perspective. Vaccine. 2013;31(SUPPL2). doi: 10.1016/j.vaccine.2012.11.084. PubMed PMID: WOS:000318462000006.

9. Jaenisch T, Tam DT, Kieu NT, Van Ngoc T, Nam NT, Van Kinh N, Yacoub S, Chanpheaktra N, Kumar V, See LL, Sathar J, Sandoval EP, Alfaro GM, Laksono IS, Mahendradhata Y, Sarker M, Ahmed F, Caprara A, Benevides BS, Marques ET, Magalhaes T, Brasil P, Netto M, Tami A, Bethencourt SE, Guzman M, Simmons C, Quyen NT, Merson L, Dung NT, Beck D, Wirths M, Wolbers M, Lam PK, Rosenberger K, Wills B. Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC Infect Dis. 2016;16(1):120. doi: 10.1186/s12879-016-1440-3. PubMed PMID: 26968374; PMCID: PMC4788847.

10. Marques Jr. ETA, Chikhlikar P, De Arruda LB, Leao IC, Lu Y, Wong J, Chen J-S, Byrne B, August JT. HIV-1 p55Gag encoded in the lysosome-associated membrane protein-1 as a DNA plasmid vaccine chimera is highly expressed, traffics to the major histocompatibility class II compartment, and elicits enhanced immune responses. Journal of Biological Chemistry. 2003;278(39):37926-36. doi: 10.1074/jbc.M303336200. PubMed PMID: WOS:000185437200115.

11. Group1 MER. Microcephaly in Infants, Pernambuco State, Brazil, 2015. Emerg Infect Dis. 2016;22(6). doi: 10.3201/eid2206.160062. PubMed PMID: 27071041.

12. Miranda-Filho DeB, Martelli CM, Ximenes RA, Araujo TV, Rocha MA, Ramos RC, Dhalia R, Franca RF, Marques Junior ET, Rodrigues LC. Initial Description of the Presumed Congenital Zika Syndrome. Am J Public Health. 2016;106(4):598-600. doi: 10.2105/AJPH.2016.303115. PubMed PMID: 26959258.

13. Nascimento EJM, Silva AM, Cordeiro MT, Brito CA, Gil LHVG, Braga-Neto U, Marques ETA. Alternative complement pathway deregulation is correlated with dengue severity. PLoS ONE. 2009;4(8). doi: 10.1371/journal.pone.0006782. PubMed PMID: WOS:000269335000025.

14. Nascimento EJM, Hottz ED, Garcia-Bates TM, Bozza F, Marques ETA, Jr., Barratt-Boyes SM. Emerging Concepts in Dengue Pathogenesis: Interplay between Plasmablasts, Platelets, and Complement in Triggering Vasculopathy. Critical Reviews in Immunology. 2014;34(3):227-40. PubMed PMID: WOS:000336553300004.

15. Viana IFT, Dhalia R, Krieger MA, Marques ETA, Lins RD, Setubal J, Almeida N. Influence of Scaffold Stability and Electrostatics on Top7-Based Engineered Helical HIV-1 Epitopes2013 2013. 94-103 p.

16. Viana IFT, Soares TA, Lima LFO, Marques ETA, Krieger MA, Dhalia R, Lins RD. De novo design of immunoreactive conformation-specific HIV-1 epitopes based on Top7 scaffold. RSC Advances. 2013;3(29):11790. doi: 10.1039/c3ra41562g.

Ernesto T. A. Marques
© 2016 by University of Pittsburgh Graduate School of Public Health

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